DEPRESSION, ANXIETY

This study tests whether giving military behavioral health technicians a special toolkit of proven mental health techniques can help prevent depression, anxiety, and stress in active-duty airmen. About 5,586 service members will take part. The goal is to see if this approach work…

This study is testing a program called TENDAI4PrEP to help pregnant women in Zimbabwe take PrEP, a daily pill that prevents HIV. The program combines problem-solving support to address barriers like depression and anxiety. About 132 pregnant women at risk for HIV will participate…

This study tests a smartphone app called Aviva that delivers therapy to help prevent suicidal behaviors. It is for military members who have had recent suicidal thoughts or attempts. Participants will be randomly assigned to use Aviva or a standard safety plan app, and researcher…

This study looks at whether eating more traditional Inuit foods (like fish and game) and taking part in cultural activities can help reduce depression and anxiety. About 40 Inuit adults in Arviat, Nunavut will be followed for 12 weeks. Researchers will measure mood changes and ho…

This study tests whether a special sleep program helps teens aged 10–19 recover from a concussion more quickly. About 54 participants will either get standard sleep advice or a detailed sleep plan. The goal is to see if better sleep leads to faster symptom relief, improved mood, …

This study tests whether a higher dose of aerobic exercise, started within two weeks of a concussion, helps teens recover faster. Researchers will measure symptom resolution, brain inflammation markers, and anxiety or depression changes. The goal is to create better rehabilitatio…

This study tests whether taking magnesium and vitamin B6 alongside usual treatment can reduce symptoms of depression, anxiety, and stress in people who recently started experiencing bipolar I disorder. About 40 adults aged 18 to 50 with a first episode in the last 10 years will r…

This study tests whether psilocybin (the active ingredient in magic mushrooms) combined with talk therapy can safely reduce depression and anxiety in people with advanced cancer. About 30 adults with incurable cancer who are on maintenance treatment will receive the therapy. The …

This study tests if a special website can help people who survived a cardiac arrest outside the hospital. The goal is to improve their quality of life, mood, thinking, and social connections. About 106 survivors will use the web app and report how they feel.

This study trains psychotherapists to give personalized talk therapy to cancer patients and their caregivers who are feeling very distressed. Therapists will learn several proven methods, like cognitive behavioral therapy and mindfulness, to help with anxiety, depression, pain, f…

This study tests whether a smartphone app called Safe Haven can help college students feel less depressed, anxious, or stressed. About 68 students will either use the app plus standard campus care, or just standard care alone. The app includes daily mood check-ins, weekly surveys…

This study is testing a mobile app called Wysa for Chronic Pain to see if personalized notifications can help people aged 45 and older who have chronic pain along with depression or anxiety. Participants use the app for several weeks and complete surveys about their mood, pain, p…

This study tests a smartphone app called Orbi, which uses cognitive behavioral therapy (CBT) techniques to help people with long-term physical health conditions manage feelings of distress, anxiety, or depression. About 60 adults in the UK will use the app plus usual charity supp…

This early-stage trial tests a generative AI chatbot called Therabot-CALM to see if it is usable and acceptable for people with cannabis use disorder who also have anxiety or depression. Fifteen adults will use the app for 4 weeks and give feedback through interviews and surveys.…

This study tests a stepped-care program to help pregnant women and new mothers who have depression or anxiety. About 2,970 women will be screened and receive different levels of support based on their needs. The goal is to improve mental health and quality of life.

This study tests a single-session online course called 'Things You Do' that teaches five simple actions to boost emotional wellbeing. Researchers want to see if it helps adults with depression and anxiety feel better. About 50 Canadian adults who are already seeking online mental…

This study tests whether a culturally adapted skills training program called START NOW can reduce depression and anxiety in teenage refugees. About 80 participants aged 14 to 18 will be randomly assigned to either the START NOW program or standard care. Researchers will compare c…

This study looks at what causes severe irritability in children aged 4 to 17 who have anxiety or mood disorders. Researchers will test psychological treatments to reduce irritability and improve emotional control. The goal is to help children and their parents manage difficult be…

This study is testing whether a type of talk therapy called Acceptance and Commitment Therapy (ACT) can help Black teenagers and young adults with sickle cell disease cope with stress related to racism. About 30 participants aged 14-21 will take part in a 10-session group therapy…

This study aims to find the best way to add small amounts of human or digital support to a meditation app for people with depression or anxiety. About 688 adults with elevated symptoms will use the Healthy Minds Program app and receive different levels of support. The goal is to …

This study will test a Spanish-language digital cognitive behavioral therapy program (SilverCloud) for 213 Latino adults in San Francisco with depression or anxiety. Participants will either use the program on their own or with support from a peer. The goal is to see if the progr…

This study tests a self-help workbook designed for people in prison who have moderate to severe anxiety or depression. About 96 adults will use the workbook for 8 weeks and be followed for 13 weeks total. The goal is to see if the workbook is helpful, easy to use, and improves me…

This study works with clinics in Massachusetts to help people in underserved communities manage weight, get cancer screenings, and improve mental health. About 3600 adults who speak English or Spanish can join if they have obesity, are behind on colon or cervical cancer screening…

This study looks at how people with anxiety or depression react to uncertain situations. Researchers will use a one-time mental exercise to see if it changes decision-making and brain activity. About 140 adults aged 25 to 60 who struggle with uncertainty will take part. The goal …

This study aims to find out which factors influence how well EMDR therapy works for people with depression. Researchers will track 40 patients and their therapists in Italy, measuring symptoms like depression, anxiety, and trauma. The goal is to understand what makes the therapy …

This study is testing a digital platform and teacher training program to reduce suicidal thoughts and behaviors in Colombian youth aged 14-19. The platform offers self-help tools, safety planning, and counseling links, while teachers get training to spot warning signs. Researcher…

This study looks at whether a community program called Harlem Strong can help Black and Latino adults in Harlem get better mental health care. About 700 people from low-income housing or local clinics will take part. The program connects health insurers, community groups, and doc…

This study is testing a mobile health toolkit called mWEL to help teachers and parents in Uganda better understand and manage their mental health. The toolkit provides self-help support, with extra help from community health workers if needed. The study will measure changes in me…

This study uses transcranial magnetic stimulation (TMS) to map brain circuits in people with depression, OCD, anxiety, or schizophrenia. Researchers will stimulate different parts of the prefrontal cortex and test how it changes behavior. The goal is to understand which brain cir…

This study looks at how the brain reacts to threats in people with depression, anxiety, or both. About 165 adults will take a single dose of an anti-anxiety drug or a placebo and then have their brain activity measured with MRI and eye-blink tests. The goal is to find differences…

This study aims to create a short, simple questionnaire that doctors can use during routine check-ups to quickly identify anxiety or depression in children, teens, and young adults who have survived childhood cancer. About 545 survivors aged 6 to 25 will help test the tool. The g…

This study looks at how a 7-week online mindfulness program helps people with anxiety or depression. About 500 adults will fill out weekly surveys about their emotions, thoughts, and behaviors. The goal is to understand which skills improve first and lead to feeling better.