DEMENTIA WITH LEWY BODIES

This study tested a cancer drug called nilotinib in 43 people with Dementia with Lewy Bodies (DLB), the second most common dementia in older adults. The goal was to see if the drug is safe and tolerable, and how it affects brain biomarkers. Participants received either nilotinib …

This study tested a drug called CT1812 in 130 people with mild to moderate Dementia with Lewy Bodies. The goal was to see if the drug is safe and if it might help with symptoms like thinking and sleepiness. Participants received either the drug or a placebo for 6 months, and rese…

This study tested an experimental drug called neflamapimod in 159 people aged 55 and older with dementia with Lewy bodies (DLB). The goal was to see if the drug could improve memory, problem-solving, and attention compared to a placebo. The trial is now complete, and researchers …

This study used special brain scans to look at two key chemical systems—acetylcholine and dopamine—in people with dementia with Lewy bodies (DLB). Researchers wanted to see if differences in these systems could help explain the varied symptoms of DLB and improve diagnosis. The st…

This study tested a dementia care program delivered by phone and web, called the Care Ecosystem, in 6 health systems across the U.S. Over 1,200 people with dementia and their caregivers took part. The program used trained navigators supervised by dementia experts to improve care …

This study tested a website called WeCareAdvisor that helps people caring for a loved one with dementia. The tool gives tips and strategies to manage challenging behaviors like aggression or wandering. Researchers wanted to see if it could lower caregiver stress and boost their c…

This study tested a virtual group therapy program called Cognitive Stimulation Therapy (V-CST) for people with mild to moderate dementia. 133 participants were randomly assigned to either join the online therapy or receive usual care. The goal was to see if the therapy could slow…

This study tested a special palliative care program for people with late-stage Alzheimer's or related dementias and their family caregivers. The program started during a hospital stay and included caregiver education and support after discharge. Researchers wanted to see if it co…

This completed study surveyed 219 family caregivers of people with dementia to understand how swallowing difficulties (dysphagia) impact caregiver burden. Caregivers completed a one-time online questionnaire about their loved one's swallowing, their own stress, and support. The g…

This study examined 186 people with different types of dementia (Alzheimer's, Lewy body, frontotemporal, and corticobasal) plus healthy volunteers to see if subtle brain signs, called neurological soft signs, differ between groups. Participants took simple movement and coordinati…

This study followed 378 people with moderate-to-severe dementia with Lewy bodies (DLB) and their caregivers for up to three years. Researchers tracked symptoms, quality of life, and caregiver experiences to find clues that death may be near within six months. The goal is to help …

This study looked at how well a new type of brain scan (PET) can tell apart different memory and thinking disorders, including Alzheimer's disease, frontotemporal degeneration, Lewy body dementia, and some psychiatric conditions. Researchers compared the new scan to a standard on…

This study looked at how dementia with Lewy bodies (DLB) changes a person's sense of self, including memory and self-concept. Researchers compared 61 older adults with DLB, Alzheimer's disease, and healthy aging using interviews and brain scans. The goal was to understand which b…

This study looked at how the brain and body communicate in 30 people, including healthy volunteers and those with conditions like autism, ADHD, Asperger's, Alzheimer's, Parkinson's, and Fragile X. Participants did natural movements like walking and pointing, and breathed slowly w…

This study collected brain wave (EEG) data from 29 people at different stages of Alzheimer's disease, from those with no symptoms to severe dementia. Researchers also included people with a related condition called dementia with Lewy bodies. The goal was to see if EEG patterns co…