DEMENTIA WITH LEWY BODIES

This study tests whether ambroxol, a common cough medicine, can slow down thinking and memory problems in people with early Dementia with Lewy Bodies (DLB). Researchers will give the drug to 180 adults aged 50-85 with mild symptoms and track changes in cognition, mood, and daily …

This study compares two antipsychotic drugs, pimavanserin and quetiapine, to see which one better reduces hallucinations and delusions in people with Parkinson's disease or dementia with Lewy bodies. About 94 participants who need to start an antipsychotic will be randomly assign…

This study tests a non-invasive brain stimulation method called tACS in 200 people with Alzheimer's, Lewy body dementia, or frontotemporal dementia. Participants receive either real or sham stimulation four times daily to see if it improves memory and thinking. The goal is to fin…

This pilot study tests whether a non-invasive brain stimulation technique called tDCS can reduce psychotic-like symptoms (like hallucinations and agitation) in people with Lewy Body Dementia. Thirty participants will receive either real or sham stimulation over two weeks. Researc…

This study aims to understand why people with Lewy body dementia (including Parkinson's disease dementia) have sudden changes in attention and thinking, called cognitive fluctuations. Researchers will use brain scans, EEG (a test that records brain waves), and thinking tests in 1…

This study checks if a key enzyme, glucocerebrosidase, is less active in people with Lewy body dementia. Researchers will compare enzyme levels in 236 participants (patients and healthy volunteers) to see if low activity is linked to the disease. If so, existing treatments for Ga…

This study aims to create a model that better predicts how different types of dementia will progress over time. Researchers will follow 500 people with early dementia or mild cognitive impairment, using blood tests and thinking assessments. The goal is to improve prognostic confi…

This early-phase study at Massachusetts General Hospital is testing a new radioactive tracer called [11C]SY08 to see if it can detect clumps of alpha-synuclein protein in the brain using PET scans. The study includes 40 people aged 50-80 with Parkinson's disease, multiple system …

This study uses a special PET scan to measure dopamine production in the brains of people with autonomic failure, including those with Parkinson's disease, Multiple System Atrophy, or Dementia with Lewy Bodies. The goal is to find early signs that predict if a person with pure au…