CANNABIS USE

This study tests whether varenicline (Chantix) helps people quit cigarettes and reduce cannabis use. About 200 adults in South Carolina who smoke and use cannabis will get either the drug or a placebo, plus counseling. All visits are done remotely.

This small pilot study tests a culturally adapted group therapy called Emotional Awareness and Expression Therapy (EAET) for Israeli adults with chronic musculoskeletal pain who also use medical cannabis. Over 8 weeks, participants attend weekly 1.5-hour group sessions focused on…

This study tests whether a brief motivational interview during a primary care visit can reduce alcohol and cannabis use among diverse teens aged 12 to 17. Researchers will enroll 500 participants who are at risk for substance use and track changes in how often they drink or use c…

This study tests a new mobile health program for young adults aged 18-29 who use cannabis frequently or use high-strength products. The program includes personalized feedback and weekly text messages to help them reflect on their cannabis use and personal goals. 120 participants …

This study tests a brief computer program designed to help teenagers ages 13-17 reduce their use of cannabis and alcohol. Participants are teens who already use both substances and want treatment. The program aims to change their automatic reactions to drug cues, and researchers …

This study looks at how THC (the active part of cannabis) changes people's desire to smoke cigarettes and how their bodies react. Researchers will give different doses of THC or a placebo to 100 adults who smoke both tobacco and cannabis. They will measure cigarette cravings, hea…

This study looks at how alcohol, cannabis, or both together change brain activity and balance. About 99 adults who regularly drink and use cannabis will do tasks while wearing an EEG cap and a movement tracker. The goal is to find better ways to tell how intoxicated someone is.

This study looks at whether smoking cannabis is linked to more aggressive lung cancer in people under 60. Researchers will compare cannabis smokers, tobacco-only smokers, and non-smokers who have lung cancer. The goal is to understand if cannabis use leads to faster-growing tumor…

This study looks at how alcohol, cannabis, and certain medications impact falls and brain function in people with HIV. Researchers will enroll 100 participants from VA clinics to test a pharmacist-led intervention and gather feedback. The goal is to understand these risks and imp…

This study looks at whether online cannabis ads that claim to help with anxiety or depression make people buy more or stronger products. About 2,000 light-to-moderate cannabis users with mild to severe anxiety or depression will shop in a realistic online store. The goal is to se…

This study looks at how THC (the active part of cannabis) changes people's desire for e-cigarettes and their body's reactions. Researchers will give different doses of THC or a placebo to 100 adults who regularly use both e-cigarettes and cannabis. They will measure how many puff…

This study looks at how high- versus low-potency cannabis affects brain structure in young adults (ages 18-25) with early psychosis. Participants take metformin, a common diabetes drug, for 6 months to see if it helps brain health. The goal is to test if this approach is practica…

This study tests whether a saliva (oral fluid) test can accurately show if a person has used cannabis recently, all done from home. Researchers will enroll 200 people aged 18-30 who use cannabis at least once a week. Participants will provide saliva and urine samples and report t…

This study looks at how cannabis use affects the amount of sedation medicine needed during wisdom tooth removal. Researchers will compare cannabis users and non-users to see differences in drug doses, heart rate, blood pressure, and breathing. The goal is to help doctors provide …

This study looks at how cannabis use changes brain function in teenagers who also have depression. Researchers will track 280 teens to see how their cannabis habits relate to their mood and thinking. The goal is to better understand the connection, not to test a new treatment.

This study looks at how different forms of cannabis edibles—chocolates, gummies, and drinks—affect thinking, coordination, and blood levels of THC. Healthy adults aged 21-55 will take part in nine sessions where they consume these products and then complete tests of memory, atten…

This study looks at how using cannabis—and stopping it—changes sleep, daily rhythms, and sensitivity to light in healthy young adults aged 18-25. Researchers will compare regular cannabis users with non-users using sleep monitors, light tests, and pupil measurements. The goal is …

This study aims to understand how cannabis use and withdrawal affect depression and suicide risk in teenagers aged 12-18 who use cannabis daily or near-daily. Researchers will use smartphone surveys multiple times a day to track mood, cannabis use, and suicidal thoughts in real t…

This study looks at how cannabis and tobacco affect the body when used together. Researchers will measure levels of THC and nicotine in the blood of 48 regular users who smoke or vape both substances. The goal is to understand the combined health risks and inform public health gu…

This study looks at how cannabis use changes brain connections in adults aged 50 and older. Researchers will use special brain scans to measure synaptic density in the hippocampus, a key memory area. The goal is to understand, not treat, the effects of cannabis on the aging brain…

This study aims to understand how 350 regular cannabis users aged 18-24 consume the drug in their everyday lives over two years. Participants will use a mobile app to report daily details like product type, dosage, and source. The goal is to identify patterns and changes in use o…

This study looks at whether brain activity related to learning can predict how well teens (ages 14-17) respond to a program aimed at reducing cannabis use. Participants get a brain scan, then attend 10 weekly virtual sessions where they report their cannabis use and take drug tes…

This study explores whether precise brain stimulation can lower cannabis cravings in people with schizophrenia or schizoaffective disorder. Researchers will use a type of magnetic stimulation (rTMS) on specific brain areas and measure changes in cravings and brain activity. The g…

This study is creating a registry of 1000 adults with cancer who use cannabis. Participants use a secure app to track their symptoms, cannabis use, and how they feel after using it. The goal is to collect real-world data to help patients and doctors make informed decisions about …