BRCA1 MUTATION

This study is for people with a certain type of advanced breast cancer (HR-positive, HER2-negative) that has a BRCA1 or BRCA2 gene mutation. It tests whether adding a new oral drug called elacestrant to the standard treatment olaparib can help keep the cancer from growing longer …

This study tests whether taking a targeted drug (olaparib) plus hormone therapy for 6 months before prostate removal surgery can eliminate or greatly reduce cancer in men with high-risk prostate cancer and specific gene changes. About 32 men will take the drugs, then have surgery…

This early-phase study tests whether combining two oral drugs, olaparib and ASTX727, can safely shrink advanced solid tumors in adults with inherited or acquired mutations in BRCA1, BRCA2, PALB2, ATM, or CHEK2 genes. About 18 participants will receive the combination to find the …

This study tests an experimental drug called ACE-86225106 in adults with advanced solid tumors (like ovarian, breast, or prostate cancer) that have not responded to standard treatments. The main goals are to check the drug's safety, find the best dose, and see if it can shrink tu…

This early-stage trial is testing a new treatment for people with metastatic pancreatic or breast cancer that has spread. The treatment combines chemotherapy drugs with high-dose vitamin C and the patient's own stem cells to try to overcome drug resistance. The main goal is to ch…

This study is testing an experimental drug called ETX-19477 in people with advanced solid tumors (like breast, ovarian, or prostate cancer) that have stopped responding to standard treatments. The goal is to find the safest dose and see if the drug can shrink tumors or slow their…

This early-stage trial tests a combination of two drugs, niraparib and irinotecan, in people with advanced solid tumors that have mutations in DNA repair genes like BRCA, ATM, or PALB2. The main goal is to find a safe dose and understand side effects. About 24 adults with cancers…

This study looks at two new approaches to cancer genetic counseling. The first part (EfFORT) tests whether having healthcare providers directly contact family members of people with harmful gene changes leads to more genetic testing, compared to the usual method of patients telli…

This study looks at whether offering online genetic testing and education to close relatives of people with BRCA mutations helps more of them get tested, compared to usual care. About 820 first-degree relatives (parents, siblings, children) will take part. The goal is to see if t…

This study aims to collect blood samples (liquid biopsies) from 2,500 people with cancer or at high risk for cancer. The samples will be stored and used in future research to better understand how cancers grow and respond to treatment. No new treatments are being tested; the goal…

This study tests a new educational guide to help women with BRCA mutations decide whether to take hormone replacement therapy after having their ovaries and fallopian tubes removed to lower cancer risk. About 50 premenopausal women scheduled for this surgery will receive either t…

This study aims to gather health data from 10,000 women in Italy who carry BRCA1 or BRCA2 gene mutations, which increase the risk of breast and ovarian cancers. By collecting information over time, researchers hope to better understand where these mutations are most common and im…