BRCA1 MUTATION

This study is testing a new way to screen for breast cancer using a laser analysis of a blood sample (liquid biopsy). Researchers will compare results from 1,100 women—some with early-stage breast cancer and some without—to see if the laser test can accurately detect cancer. If s…

This study tests a surgery called radical fimbriectomy for women with BRCA mutations who are at high risk for pelvic cancer but want to avoid removing their ovaries. The surgery removes only the fallopian tubes, where many of these cancers start, while keeping the ovaries working…

This study looks at whether a web-based educational program can help relatives of people with BRCA1 or BRCA2 mutations understand their genetic testing options. About 240 adults who have a close family member with a BRCA mutation will be randomly assigned to either the online edu…

This study looks for new gene mutations in 800 people with lobular breast cancer or a related precancerous condition. Researchers will test blood samples for changes in 113 genes. If a high-risk mutation is found, preventive surgery may be offered; for moderate- or low-risk mutat…

This study looks at how to offer BRCA gene testing to more people, especially those of Ashkenazi Jewish descent, and make it a normal part of medical care. Over 5,400 participants will receive education and then decide if they want testing. Researchers will track who gets tested,…

This study looks at how well the immune system works in healthy people with BRCA1 or BRCA2 mutations. Researchers will give the seasonal flu vaccine to 50 participants and measure their antibody levels. The goal is to learn if these genetic changes affect overall immune health.