BRAIN METASTASES, ADULT

This study tests whether giving focused radiation before surgery for large brain metastases (tumors that spread from other cancers) works better than radiation after surgery. About 146 adults with 1-4 brain tumors will be randomly assigned to one of the two timing schedules. The …

This study tests whether adding the drug azeliragon to targeted radiation therapy can safely shrink brain tumors and keep them from growing back. About 46 adults with cancer that has spread to the brain will take part. The goal is to improve tumor control, not to cure the disease…

This study tests if giving a single radiation dose before brain metastasis surgery can lower the chance of cancer spreading to the lining of the brain, compared to five doses after surgery. About 200 adults with brain tumors that can be removed will take part. The main goal is to…

This study tests an experimental oral drug called NEO212 in adults with certain brain tumors (astrocytoma, glioblastoma) or cancers that have spread to the brain. The goal is to find the safest dose and see if it can slow tumor growth. About 134 participants will receive NEO212 a…

This study is testing whether a precise type of radiation called stereotactic radiosurgery (SRS) can help people with small cell lung cancer that has spread to the brain. About 62 adults with up to 20 brain tumors will receive SRS, and researchers will track how many are alive af…

This study is for people with breast cancer that has spread to the brain. It tests a treatment plan that starts with focused radiation plus a drug called olaparib, followed by an immunotherapy drug (durvalumab) and standard chemotherapy. The goal is to see if this combination is …

This study will collect MRI scans from 3,000 adults with brain tumors (gliomas, metastases, or lymphoma) to train an artificial intelligence system. The goal is to help doctors identify tumor types more accurately without surgery, potentially reducing the need for biopsies. Parti…

This study tests whether the seizure drug levetiracetam (Keppra) can prevent first-time seizures in people with brain metastases located in the motor cortex. About 150 adults who have never had a seizure will be randomly assigned to take the drug or receive usual care. The goal i…

This study compares intensive multi-disciplinary care to standard care for 40 adults with newly diagnosed brain metastases. The goal is to see if the team approach reduces symptom burden and helps patients better understand their prognosis. Participants will report symptoms and c…

This study is testing whether a special PET scan using 18F-Fluciclovine can help doctors see how brain tumors respond to a precise type of radiation called stereotactic radiosurgery (SRS). About 46 adults with brain metastases (tumors that spread from other cancers) will get the …

This study aims to develop and test a new MRI technique that may help doctors tell the difference between actual tumor growth and changes caused by radiation treatment in people with brain metastases. About 119 participants, including healthy volunteers and patients, will undergo…

This study tests a new approach called pharmacoscopy, which quickly checks how a patient's own brain tumor cells respond to different drugs in the lab. The goal is to see if this personalized method helps doctors choose better treatments for people with brain metastases who have …

This study is creating a collection of blood samples from 300 adults with primary or metastatic brain tumors treated at Duke Cancer Center. Researchers will analyze immune cells in the blood to better understand these tumors. The goal is to provide a resource for future studies, …

This study looks at whether CT and MRI scans can help predict how well brain tumors will respond to radiation treatment. Researchers will scan 90 adults with brain metastases before and after radiotherapy. The goal is to validate imaging biomarkers that could guide personalized t…

This study looks at whether doing radiation planning and treatment on the same day can better target fast-growing brain tumors. About 60 adults with brain metastases from solid cancers will be randomly assigned to receive radiation with a very small or no extra safety margin. The…

This study looks at whether a special imaging agent called 18F-fluciclovine can help doctors see if radiation therapy is working on large brain tumors that have spread from other cancers. About 20 adults with at least one untreated brain tumor larger than 2 cm will get PET/CT sca…