BRAIN METASTASES, ADULT

This study compares two radiation methods for patients whose cancer has spread to the brain and who are receiving immunotherapy. Researchers want to see if spreading radiation over several days causes fewer side effects than giving it all at once. The trial will enroll 244 adults…

This study is testing a three-part treatment for breast cancer that has spread to the brain. It combines a focused radiation treatment (radiosurgery) with a pill called olaparib, followed by an immunotherapy drug (durvalumab) plus the doctor's choice of standard therapy. The goal…

This study compares two approaches to radiation treatment for brain tumors that have spread from other cancers. Researchers want to see if giving a single radiation treatment before surgery works better than giving five treatments after surgery to prevent cancer from spreading to…

This study is testing whether a precise, high-dose radiation treatment called stereotactic radiosurgery (SRS) can help people with small cell lung cancer that has spread to the brain. It will measure how many participants are still alive 6 months after receiving the treatment. Th…

This study is testing a personalized approach to find better drug treatments for cancer that has spread to the brain (brain metastases). Researchers will take a small sample of a patient's tumor during surgery and quickly test many different drugs on it in the lab to see which on…

This study is testing a new oral medication called NEO212 for adults with specific aggressive brain tumors (like glioblastoma) or brain metastases from other cancers. The main goals are to find a safe and effective dose, see how the body processes the drug, and check if it can he…

This study is testing a new way to deliver radiation to brain tumors that have spread from other cancers. The goal is to plan and deliver the radiation on the same day, which may help the treatment better target tumors that can shift position. Researchers will also compare using …

This study is testing whether adding a new drug called azeliragon to a precise form of radiation therapy is safe and more effective at controlling brain tumors that have spread from other cancers. It will involve about 46 adult patients with small brain tumors. The main goal is t…

This study aims to develop an artificial intelligence (AI) system to help doctors more accurately diagnose common malignant brain tumors from MRI scans. It will use images and confirmed diagnoses from 3,000 adults with brain tumors to train and test the AI. The goal is to create …

This study is developing a new type of MRI scan to help doctors tell the difference between brain tumors that are growing because cancer is getting worse and tumors that appear larger due to swelling from radiation treatment. The research involves healthy volunteers and patients …

This study is testing whether a medication called levetiracetam (Keppra) can prevent seizures in patients who have brain tumors in a specific, high-risk brain area called the primary motor cortex. The trial will enroll 150 adult patients who have not yet had a seizure. Participan…

This study is testing whether a more organized, team-based approach to care helps patients with newly diagnosed brain metastases feel better and understand their prognosis more clearly. It will compare this intensive care model to standard care, focusing on patient-reported sympt…

This study aims to collect and store blood samples from adults with brain tumors to create a research repository. Researchers will analyze these samples to find biological markers in the blood that may predict how patients respond to radiation therapy. The goal is to gather knowl…

This study is testing whether special brain scans (MRI and CT) taken before and after radiation treatment can predict how well patients with brain metastases will respond. Researchers want to see if changes visible on these scans can help doctors choose the best treatment approac…

This study is testing whether a new type of imaging scan, called an 18F-fluciclovine PET/CT, can better show if radiation treatment is working for large brain tumors that have spread from cancer elsewhere in the body. Researchers will enroll 20 adults with these large brain metas…