ARTERIOVENOUS MALFORMATIONS

This study tests whether sirolimus, a drug used to prevent organ rejection, can reduce the size and symptoms of severe arteriovenous malformations (AVMs) — tangled blood vessels that can cause pain, bleeding, and other problems. About 50 people aged 2 and older with advanced AVMs…

This study tests two targeted drugs for people with vascular malformations (abnormal blood or lymph vessels). Participants with slow-flow malformations and a specific gene mutation receive alpelisib, while those with fast-flow malformations and another mutation receive mirdametin…

This study follows 1000 adults who had embolization for brain arteriovenous malformations (AVMs) to collect standardized long-term data. Currently, follow-up methods vary widely, so reliable information is scarce. Participants will have angiographic checks to see if the AVM remai…

This study follows 400 pregnant women with rare blood vessel disorders (like HHT, Marfan syndrome, or lymphedema) to learn about complications during and after pregnancy. Researchers will collect data via phone questionnaires over 12 months. The goal is to improve medical recomme…

This study is collecting information from 4,500 people who have had brain surgery for conditions like aneurysms, tumors, or epilepsy. The goal is to find out what factors help predict recovery, such as thinking skills and emotional health. By standardizing how outcomes are measur…

This study looks at how genetic changes influence the outlook for people with brain or spinal cord arteriovenous malformations (AVMs). Researchers will analyze DNA from 300 participants to find links between specific gene mutations and disease progression. The goal is to better u…