AMYLOIDOSIS

This study tests whether adding an experimental drug (SCTC21C) to standard chemotherapy helps people newly diagnosed with AL amyloidosis, a rare disease where abnormal proteins build up in organs. About 90 adults will be randomly assigned to get the new combo or chemo alone. The …

This study is for people newly diagnosed with multiple myeloma or amyloidosis. It tests whether a sensitive genetic test can identify patients who may safely delay a stem cell transplant. Participants receive standard drug therapy first; if the test shows very low cancer levels, …

This study is testing a new radioactive tracer called Iodine-124 evuzumitide to see if it can more accurately diagnose cardiac amyloidosis, a condition where abnormal proteins build up in the heart. About 150 adults with known or suspected amyloidosis will receive the tracer and …

This study is testing a new radioactive tracer called [18F]FT8 for PET/CT scans to see if it can safely and accurately detect amyloid deposits in people with amyloidosis, a condition where abnormal proteins build up in organs like the heart. Researchers will compare the new scan …

This study tests whether the experimental drug acoramidis can prevent or delay heart and nerve damage in people who carry a faulty gene for transthyretin amyloidosis (ATTR) but have no symptoms yet. About 582 adults aged 18 to 75 with a known disease-causing TTR gene variant will…

This study tests a new MRI method called magnetic resonance elastography (MRE) to measure heart stiffness in people with cardiac amyloidosis, a rare disease where abnormal proteins build up in the heart. Researchers will enroll 20 adults to see if the technique is feasible and ho…

This study tests a new, non-invasive heart scan called magnetocardiography (MCG) to see if it can detect and monitor amyloidosis, a rare disease where abnormal proteins build up in organs. Researchers will compare MCG results with standard ECG in 500 adults. This is an observatio…

This study looks at how often amyloidosis, a rare disease where abnormal proteins build up in organs, is found in people having trauma surgery. Researchers will check 246 patients for certain warning signs, called red flags, like age over 65 or heart problems. The goal is to lear…

This study builds a registry of 2000 adults with plasma cell disorders, such as multiple myeloma and amyloidosis. Participants complete health assessments and may give a blood sample to study aging markers. The goal is to gather data that will support future research, not to test…

This study tests whether generative AI can help doctors better diagnose complications of rheumatoid arthritis (RA), such as lung or heart problems. Researchers will use AI to analyze patient records and suggest possible hidden conditions. Doctors will then decide if the AI's sugg…

This study is creating a large database to collect information from 380 people with rare diseases like amyloidosis, sarcoidosis, and many others. Researchers will track survival, treatments, and side effects over time. The goal is to better understand these conditions and improve…