AMYLOIDOSIS

This study tests a new treatment called AZD0120 for people with AL amyloidosis that has come back or not responded to other therapies. AZD0120 is a type of immunotherapy that uses a patient's own immune cells to target and destroy harmful cells. The study aims to see if this trea…

This study tests whether adding the experimental drug SCTC21C to standard chemotherapy (bortezomib, cyclophosphamide, dexamethasone) works better than chemo alone for people newly diagnosed with AL amyloidosis, a rare disease where abnormal proteins damage organs. About 90 adults…

This study tests a single dose of a gene therapy called NTLA-2001 in 60 people with a rare inherited nerve disease (ATTRv-PN). The goal is to see if it can safely reduce harmful protein buildup and slow nerve damage compared to a placebo. Participants must have a confirmed diagno…

This study tests whether people newly diagnosed with multiple myeloma or amyloidosis can safely postpone a stem cell transplant if they achieve a very deep response (called minimal residual disease negativity) after 6 cycles of a powerful drug combination. About 40 participants w…

This study tests a drug called belantamab mafodotin in people with AL amyloidosis, a rare disease where abnormal proteins build up in organs. The goal is to find the safest and most effective dose to control the disease. About 37 participants will be enrolled, and the study has t…

This program provides early access to venetoclax, a targeted therapy for several blood cancers including chronic lymphocytic leukemia (CLL), acute myeloid leukemia (AML), and multiple myeloma. It is for people who have no other suitable treatments and cannot join a clinical trial…

This study is testing a new imaging agent called [18F]FT8 for PET/CT scans to see if it can safely and clearly show amyloid deposits in people with amyloidosis, a condition where abnormal proteins build up in organs. Researchers will compare the new scan with standard tests like …

This study is testing a new imaging method using a special tracer called I-124 evuzumitide to better diagnose cardiac amyloidosis, a condition where abnormal proteins build up in the heart and other organs. About 150 adults with known or suspected amyloidosis will receive a PET/M…

This study aims to see if a special dye used during PET/CT scans can find protein clumps (amyloidosis) in internal organs without needing a tissue biopsy. It involves 30 adults with CAPS who developed amyloidosis from the drug anakinra. Participants will have scans every 6 months…

This study tests an experimental drug called acoramidis in 587 adults aged 18–75 who carry a faulty gene that causes transthyretin amyloidosis (ATTR) but have no symptoms yet. The drug aims to stabilize a key protein and prevent or delay the buildup of harmful plaques in the hear…

This study tests whether giving cancer treatment at home is preferred over going to a clinic. It involves 27 adults with various cancers in the Florida Panhandle. The goal is to see if home care improves patient satisfaction and is safe.

This study looks at whether a special MRI technique called magnetic resonance elastography (MRE) can measure stiffness in the heart muscle of people with cardiac amyloidosis. Researchers will enroll 20 adults with this condition to see if the scan is feasible and provides useful …

This study is creating a large database to collect information about people with rare diseases like amyloidosis, sarcoidosis, and many others. Researchers will track patients' health, treatments, and outcomes over time. The goal is to better understand these conditions and improv…

This study tests a new, non-invasive heart scan called magnetocardiography (MCG) to see if it can detect and monitor amyloidosis, a rare disease where abnormal proteins build up in organs. Researchers will compare MCG results with standard ECG in 500 adults. The goal is to improv…

This study checks how often amyloidosis (a rare disease where abnormal proteins build up in organs) is found in people having planned trauma surgery. Researchers will use a simple checklist of warning signs, called red flags, to spot possible cases. About 246 adults on the surger…

This study is building a registry of 5,000 adults aged 50 and older with blood cancers like multiple myeloma and lymphoma. Researchers will collect information on frailty, muscle loss, and other age-related health issues. No treatments are given—the goal is to gather data to supp…

This study looks at whether a type of artificial intelligence (AI) can help doctors better identify complications in people with rheumatoid arthritis (RA). Researchers will use AI to suggest possible complications from patient records and see if doctors agree with and use those s…

This study follows 200 adults with ATTR amyloidosis who are taking the drug tafamidis. Researchers will check every six months for heart rhythm problems that might need a pacemaker or defibrillator. The goal is to learn how often these issues occur and improve monitoring in routi…

This study is creating a biobank and data registry for people with amyloidosis, a rare disease where abnormal proteins build up in organs. Researchers will collect blood, urine, and tissue samples along with medical information from 505 participants. The goal is to store these ma…

This study is building a registry of 2,000 adults with plasma cell disorders, such as multiple myeloma and amyloidosis. Participants will fill out health questionnaires and may give a blood sample to study aging markers. The goal is to gather information to support future researc…

This study is creating a registry of 500 people with amyloidosis to track how the disease develops, how it is treated, and how patients fare over time. Researchers will collect information on risk factors, diagnosis, treatment patterns, and survival. The goal is to better underst…