ADVANCED MELANOMA
Clinical trials for ADVANCED MELANOMA explained in plain language.
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New drug cocktail shows promise against Tough-to-Treat skin cancer
Disease control CompletedThis early-stage trial tested the safety and initial effectiveness of a three-drug combination for people with advanced melanoma that cannot be removed by surgery. The study involved 79 participants and aimed to find the safest dose and see if the drugs could help control the can…
Matched conditions: ADVANCED MELANOMA
Phase: PHASE1 • Sponsor: Nanjing Leads Biolabs Co.,Ltd • Aim: Disease control
Last updated Apr 03, 2026 14:43 UTC
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Early trial tests Two-Drug attack on Tough-to-Treat skin cancer
Disease control CompletedThis early-stage study tested the safety and initial effectiveness of combining two cancer drugs, trametinib and ceritinib, in patients with advanced melanoma that could not be surgically removed. The trial involved 27 patients whose cancer had worsened despite previous standard …
Matched conditions: ADVANCED MELANOMA
Phase: PHASE1 • Sponsor: H. Lee Moffitt Cancer Center and Research Institute • Aim: Disease control
Last updated Apr 02, 2026 14:57 UTC
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New cancer drug injected directly into tumors shows promise in early trial
Disease control CompletedThis early-stage study tested a new drug, CyPep-1, which is injected directly into tumors. It was combined with the immunotherapy drug pembrolizumab to see if it could help control advanced head and neck cancer, melanoma, or triple-negative breast cancer. The main goals were to c…
Matched conditions: ADVANCED MELANOMA
Phase: PHASE1, PHASE2 • Sponsor: Cytovation AS • Aim: Disease control
Last updated Mar 30, 2026 14:32 UTC
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Personalized vaccine shows promise against deadly skin cancer
Disease control CompletedThis study tested whether adding a personalized cancer vaccine (autogene cevumeran) to standard immunotherapy (pembrolizumab) works better than immunotherapy alone for people with advanced melanoma that hasn't been treated before. The trial involved 131 patients with advanced ski…
Matched conditions: ADVANCED MELANOMA
Phase: PHASE2 • Sponsor: Genentech, Inc. • Aim: Disease control
Last updated Mar 27, 2026 12:38 UTC
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Direct tumor shots tested to revive immune attack on stubborn melanoma
Disease control CompletedThis study tested a new approach for patients with advanced melanoma that had stopped responding to standard immunotherapy. Doctors injected an experimental drug called LTX-315 directly into accessible tumors, while also giving the immunotherapy drug pembrolizumab. The goal was t…
Matched conditions: ADVANCED MELANOMA
Phase: PHASE2 • Sponsor: Lytix Biopharma AS • Aim: Disease control
Last updated Mar 18, 2026 18:25 UTC
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Blood test could predict which melanoma patients benefit from immunotherapy
Knowledge-focused CompletedThis study aimed to understand why some patients with advanced melanoma respond to immunotherapy while others don't. Researchers analyzed blood samples from 25 patients receiving standard pembrolizumab treatment to identify immune cell patterns linked to treatment success. The go…
Matched conditions: ADVANCED MELANOMA
Sponsor: University of California, San Francisco • Aim: Knowledge-focused
Last updated Apr 03, 2026 14:42 UTC
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Scientists bank cancer samples to crack treatment resistance code
Knowledge-focused CompletedThis study collected blood and tumor tissue samples from 64 patients with advanced cancers to build a research library. The goal was to understand why cancers stop responding to treatments and to find better ways to match future patients with effective therapies. Samples were tak…
Matched conditions: ADVANCED MELANOMA
Sponsor: National Cancer Institute (NCI) • Aim: Knowledge-focused
Last updated Mar 13, 2026 15:06 UTC