ACNE VULGARIS

This study tests whether a low daily dose of the acne drug isotretinoin can clear moderate to severe acne as effectively as the standard dose, but with fewer side effects. About 164 people aged 18-45 will be randomly assigned to one of two dose groups. Researchers will track acne…

This study is testing a gel called CABTREO, which combines three acne-fighting ingredients (clindamycin, adapalene, and benzoyl peroxide), in children aged 9 to 11 with moderate to severe acne. The goal is to see if it is safe and works well over 12 weeks. About 100 kids will app…

This study tests three different gels for mild-to-moderate acne in 189 people aged 15-40. One gel is a standard antibiotic-retinoid mix, another adds a steroid, and the third is a new gel made from stem-cell secretions. The goal is to see which works best at reducing pimples and …

This study will test whether a gel containing dutasteride (0.05%) works better than a standard triple-combination gel (clindamycin, benzoyl peroxide, adapalene) for treating facial acne in 50 adults aged 18 and older. The researchers will count pimples, check skin improvement, an…

This study tests a cream called clascoterone for moderate to severe acne. About 692 people aged 12 and older will apply the cream or a placebo to their face twice daily for 12 weeks. The goal is to see if the cream reduces acne lesions and improves skin appearance better than pla…

This early-stage study tests a new drug called HB0043 in 21 adults with moderate to severe facial acne. The drug is a bispecific antibody that blocks two inflammatory proteins (IL-17A and IL-36R) thought to drive acne. The main goals are to see if it safely reduces pimple counts …

This study tests whether taking oral probiotics for 12 weeks can reduce acne lesions and lower inflammation in people with moderate acne. Researchers will compare probiotics to a placebo in 64 Pakistani participants aged 15-35. The goal is to find a safe, antibiotic-free way to m…

This study tests a new topical gel containing 5% spironolactone against a standard 0.1% adapalene gel for treating acne. Forty people with mild to moderate acne will apply each gel to opposite sides of their face, allowing direct comparison. The goal is to see if the spironolacto…

This study tests a new cream called KR230109 for mild to moderate acne. About 180 people aged 18 to 40 will use the cream or a placebo for 12 weeks. The goal is to see if the cream safely reduces pimples and skin bumps better than no treatment.

This study compares two prescription gels—metronidazole and clindamycin—to treat moderate acne in adults aged 18-35. Sixty participants will apply the assigned gel twice daily for 12 weeks. The goal is to see which gel reduces acne more effectively and causes fewer side effects l…

This study will measure three types of fats (ceramides and S1P) in the blood of 40 people with acne and 40 healthy volunteers. The goal is to see if these fats are different in acne patients and if they relate to acne severity. No treatment is given—just a blood draw. The results…