ACNE VULGARIS

This completed Phase 1 trial compared a generic tretinoin gel (0.04%) to the brand-name RETIN-A MICRO for treating acne vulgaris. Over 1,000 participants aged 12 to 40 with mild to moderate acne applied the gel daily for 12 weeks. The goal was to see if the generic version works …

This Phase 2 trial tested an injected antibody called imsidolimab in 123 people with moderate to severe facial acne. The goal was to see if it reduces inflamed pimples better than a placebo over 12 weeks. The study is complete, and results will show whether this approach could be…

This completed trial tested whether adding vitamin D supplements to standard acne treatment (azithromycin and a topical retinoid) improves acne more than standard treatment alone. Fifty-eight people aged 13 to 40 with acne vulgaris took part. The main goal was to see if the combi…

This study tested a combination of two acne treatments—Winlevi (a hormone-blocking cream) and adapalene 0.3% gel—to see how well they work together in real-life use. Twenty people with acne used both treatments for 16 weeks. The main goal was to see how many achieved clear or alm…

This study tested the acne cream Winlevi in 10 people with darker skin tones (Fitzpatrick types IV, V, VI). The goal was to see how well it cleared or nearly cleared acne after 16 weeks. Acne is very common, but there is little research focused on skin of color, so this study hel…

Pfizer completed a Phase 1 study testing a new topical drug called PF-07905428 for acne. The study included 52 healthy volunteers and people with moderate to severe acne, who applied the drug daily for 14 or 28 days. The main goal was to check safety and side effects, not to see …

This Phase 2 trial tested a new acne gel called IDP-126 against a standard gel (Epiduo Forte) and a placebo gel in 686 people aged 12 and older with moderate to severe acne. Participants applied the gel once daily for 12 weeks. Researchers measured changes in acne lesion counts a…

This study tested whether adding ear acupressure to a standard acne gel (adapalene) helps clear pimples better than the gel alone. Researchers enrolled 64 people with mild to moderate acne and compared the combination to the gel-only group. The goal was to see if the combo reduce…

This study tested a facial moisturizer in 47 people with mild to moderate acne to see if it was gentle and helpful over 4 weeks. Researchers checked skin dryness, redness, and overall appearance, and participants shared how their skin felt. The goal was to see if the moisturizer …

This study tested whether the diabetes drug metformin can treat moderate to severe facial acne as well as the antibiotic doxycycline. Sixty-eight people aged 12 to 40 took either metformin twice daily or doxycycline once daily for 12 weeks. Researchers counted pimples and used a …

This study tested a treatment called dextrose phonophoresis for mild to moderate acne. It involved 115 people aged 18 to 30. The treatment uses ultrasound to help a sugar solution (dextrose) penetrate the skin, aiming to reduce acne lesions and severity. The study is now complete…

This study tested a gel containing dapsone (7.5%) against a placebo gel in 100 adults with mild-to-moderate acne. Participants applied the gel once daily for 8 weeks, and researchers tracked changes in acne lesions, skin oil, redness, and quality of life. The goal was to see if t…

This study looked at whether taking probiotics can reduce a protein in the blood linked to acne inflammation. Researchers measured this protein in 50 adults with mild to moderate acne before and after probiotic treatment. The goal was to see if probiotics could help ease acne sym…