Vascular brain injury

This study tests a community-based exercise program for people aged 50 and older who have at least two chronic conditions, such as heart disease, diabetes, arthritis, or obesity. The program is designed to improve muscle strength, heart and lung fitness, and overall well-being. R…

This study tests whether giving creatine monohydrate, a popular sports supplement, twice a day for 12 weeks is safe and practical for children and teenagers recovering from a moderate-to-severe brain injury, including traumatic brain injury or stroke. The trial will enroll 46 par…

This trial investigates whether a structured exercise and physical activity program can improve health-related quality of life and daily physical activity in adults who have had an acquired brain injury. Thirty participants will either receive the exercise program plus usual care…

This trial compares two ways to humidify air for trauma patients on prolonged mechanical ventilation: active heated humidifiers and passive heat-and-moisture exchangers. The goal is to see which method reduces airway complications like mucus plugs and tube blockages, and improves…

This trial tests whether a rehabilitation program that targets different aspects of balance can improve balance, mobility, walking, and quality of life in adults with acquired brain injury (from stroke, trauma, or other causes). Participants are randomly assigned to either the ba…

This study tests whether a new shelf-stable blood product (IFC) works faster than the standard cryoprecipitate to stop severe bleeding in trauma patients. About 320 adults with traumatic injuries and low fibrinogen levels will be enrolled. The goal is to see if IFC can be given m…

This study tests whether a personalized weaning strategy can help adults with chronic heart, brain, or lung conditions leave ventilators earlier. The strategy tailors care based on the main reason a patient struggles to breathe on their own, such as heart or muscle problems. Rese…

This study looks at whether applying a patient's own skin cells (called a basal cell suspension) to surgical wounds can help them heal faster and with less scarring. Researchers will compare 500 people who get this extra treatment with 500 who get standard surgery alone. The goal…

This study is testing whether adding a cold atmospheric plasma device to standard wound care helps different types of wounds heal better. The device uses low-temperature plasma to kill bacteria and promote healing. Researchers will compare 500 patients who get plasma therapy plus…

This study tests whether giving growth hormone to elderly patients (60+) with moderate to severe brain injury and low blood protein can improve their nutritional status. Half of the 160 participants will get daily growth hormone shots plus standard care, while the other half gets…

This study adapts and validates Italian versions of two clinical scales for patients with disorders of consciousness after severe brain injury. The Brief Evaluation of Receptive Aphasia (BERA) assesses language understanding using eye movements, and the SWallowing Assessment in D…

This study tests whether a higher dose of the blood thinner enoxaparin can better prevent dangerous blood clots in the legs or lungs of severely injured patients. About 540 adults in intensive care after trauma will receive either the standard or a double dose. The goal is to see…

This study looks at whether a single dose of the antibiotic ceftriaxone can prevent early pneumonia in 60 brain-injured patients who need a breathing tube. Researchers will measure drug levels in the blood to see if enough reaches the infection site, especially in patients with f…

Researchers at the University of Alabama at Birmingham are testing whether a ketogenic tube feeding, high in fat and low in carbohydrates, is safe and practical for adults aged 55 and older hospitalized with traumatic injuries. They compare it with standard hospital tube feeding …

This trial tests whether using a weighted blanket during a hospital stay can reduce pain and anxiety in adults recovering from traumatic injuries. Half of the 50 participants will receive a weighted blanket, while the other half gets a standard hospital blanket. Researchers will …

This study will compare two pain medications, buprenorphine and oxycodone, in about 282 adults with injuries to at least two body areas. The goal is to see which provides better pain control with fewer risks. Participants will receive one of the two drugs as part of a standard pa…

This trial tests a soft, wearable robotic exoskeleton designed to assist arm and hand movements in people with acquired brain injury. Participants, including healthy volunteers, perform a set of arm movements with and without the device's help. The study measures how usable the d…

This early study tests whether a low-level magnetic therapy device, used at home, is safe and practical for people with cognitive issues from brain injury, Long COVID, or Alzheimer's. About 30 adults will use the device regularly and complete computer-based thinking tests. The go…

This study tests if using augmented reality (AR) games can make rehabilitation therapy more engaging for people with acquired brain injury (like from a stroke or trauma). The goal is to see if this fun approach helps patients stick with their therapy, which could lead to better r…

This study tests a program called COMA-F, designed to help caregivers of patients with severe acute brain injury manage emotional distress. The program teaches skills to cope with uncertainty and long-term caregiving challenges. Researchers will compare it to a basic education pr…

This study tests whether listening to music with binaural beats (a type of sound that may influence brain activity) can help professional athletes who are afraid of getting hurt again after a musculoskeletal injury. Sixty-six athletes will listen to either binaural beat music, a …

This study tests whether virtual reality relaxation sessions can help adults with acquired brain injury who live in nursing homes and have emotional or behavioral issues. Three participants will use a multisensory VR device for 15–20 minutes twice a week over 8 weeks. Researchers…

This study looks at whether giving trauma patients personalized information and a voluntary digital follow-up visit (instead of only standard care) helps them have less disability, return to work more often, and feel better overall. About 256 adults admitted to a Norwegian trauma…

Researchers at Radboud University Medical Center are asking what adults with serious trauma injuries and financial concerns need from physical therapy. The study includes 17 people in the Netherlands who were injured between three months and two years earlier. Through interviews,…

Researchers are studying whether adding the FOUR Score, a detailed measure of consciousness, to four existing trauma scoring systems improves their ability to predict death in adult trauma patients. The study enrolls about 2,000 injured adults across multiple hospitals. Participa…

Researchers want to understand what concerns trauma patients most right after an injury. The study enrolls 300 adults who arrive at the emergency department with an acute injury and are stable enough to take part. Participants fill out a questionnaire about their stress, pain, an…

This large registry study will follow over 2,700 postmenopausal women aged 45-75 who use newer forms of hormone replacement therapy (creams, gels, sprays). The goal is to see if these modern delivery methods lower the risk of heart attacks, strokes, and other cardiovascular event…

This trial tests a software device called AI-TRiPS that uses real-time data from ambulances to predict the risk of death, bleeding, kidney injury, and need for blood transfusion in trauma patients. The tool displays these predictions to hospital trauma teams before the patient ar…

This study aims to translate and adapt an English scale (EmNSA) into French to better assess sensation in the legs of adults with acquired brain injury. Researchers will test the new French version on 50 patients to ensure it is accurate and reliable. The goal is to provide a val…

This study tests a new method that uses carbon dioxide measurements to help doctors set breathing machines more precisely for brain injury patients. The goal is to reduce lung damage while keeping the patient stable. The study will include 30 adults in a neuro-intensive care unit…

This study will train over 1,800 lay first responders—like taxi drivers and shopkeepers—in Cameroon to provide basic first aid and safe transport for injured people. Researchers will compare survival rates before and after the training program. The goal is to see if a data-driven…

This study will test a new program designed to help people who have been hospitalized for a physical injury. The program connects survivors with resources to meet their medical and social needs. Researchers will interview 25 participants and track which resources they use to see …

This study compares two ways to perform brain angiography: accessing an artery through the wrist (transradial) versus the groin (transfemoral). Over 2,400 people needing this imaging test will be randomly assigned to one method. Researchers will measure success rates, complicatio…

This study aims to develop a new EEG-based technique to detect 'cognitive-motor dissociation'—where a patient is aware but cannot move. Researchers will stimulate the median nerve (in the wrist) and analyze brain signals in 50 comatose ICU patients. The goal is to identify those …

This study will look at brain scans (MRI/CT) and symptoms of over 1,100 people with cerebrovascular disease. The goal is to find patterns linking specific scan findings to different types of the disease. This could help doctors diagnose and treat these conditions more accurately …

This observational study will use a non-invasive brain-computer interface and artificial intelligence to detect and record brain activity in terminally ill patients immediately after clinical death. Researchers aim to capture organized neurocognitive signals, such as gamma waves,…

This study looks at 400 severely injured patients treated by emergency medical teams in the Paris region. It aims to see if the time spent on scene before going to the hospital affects whether patients survive the first 24 hours. The goal is to find ways to improve emergency care…

This study looks at how air moves in the lungs of brain-injured patients when doctors are removing their breathing tube. Using a special imaging belt (electrical impedance tomography), researchers will track changes in lung ventilation patterns. The goal is to find patterns that …

This study will analyze data from a pediatric trauma registry to understand injury patterns, outcomes, and what factors predict how severe an injury is. Researchers will look at records of 40 children under 18 who came to the hospital with a traumatic injury. The goal is to learn…

This study tests whether giving metoclopramide alone or with dexamethasone can speed up stomach emptying in trauma patients needing emergency surgery. Using bedside ultrasound, researchers will measure stomach contents to see which drug works better. The goal is to reduce the ris…

This study tests a new peer support program for adults recovering from serious injuries like car crashes, burns, or amputations. The program pairs survivors with trained peers who have been through similar experiences, offering support from hospital to home. The goal is to see if…