Urolithiasis

This study tests whether giving people a live gut bacterium called Oxalobacter formigenes can lower the amount of oxalate in their urine. High urinary oxalate is a major risk factor for calcium oxalate kidney stones. Forty adults with a history of such stones who lack this bacter…

This trial investigates whether adding norepinephrine to the irrigation fluid used during a type of kidney stone surgery can reduce bleeding and improve visibility for the surgeon. The study will enroll adults with kidney or upper ureteral stones who are undergoing a procedure us…

This study tests whether a herbal supplement called Neorenal Forte can help eliminate small leftover kidney stone fragments after laser surgery. About 120 adults with kidney stones will take either the supplement or a placebo for three months. The goal is to see if more people be…

This study tests a new device called the CVAC system that uses suction during a scope procedure to remove kidney stones. It compares how well this works versus the usual method (laser and no suction) in 150 adults. The main goal is to see if the new tool leaves fewer stone fragme…

This trial compares a new aspiration-enabled access sheath to a conventional one during retrograde intrarenal surgery (RIRS) for kidney stones. The new sheath continuously removes irrigation fluid to control pressure inside the kidney, potentially reducing temporary kidney injury…

This study tests whether using an antibiotic (gentamicin) in the irrigation fluid and a special suction tube during kidney stone surgery can lower the chance of fever, inflammation, or sepsis afterward. About 180 adults having this surgery will be randomly assigned to receive one…

This study tests a new device called the Enhanced Lithotripsy System (ELS) that uses low-pressure ultrasound to activate tiny bubbles in the urine, breaking kidney or ureter stones into small pieces that can pass naturally. The trial will enroll 101 adults with a single stone in …

This study tests whether hydroxycitrate, a molecule similar to citrate, can reduce the recurrence of calcium phosphate kidney stones. Researchers will give 25 stone formers either hydroxycitrate, potassium citrate, or a placebo, and measure how well their urine prevents stone for…

This study compares two modern, minimally invasive surgeries for removing kidney stones that are 2-3 cm in size. About 120 adults will be randomly assigned to either mini-percutaneous nephrolithotomy (Mini-PCNL) or flexible ureteroscopy with a suction sheath. The goal is to see w…

This study tests a new ultrasound device that can break kidney stones into tiny pieces and reposition them, all without anesthesia. Researchers will enroll 140 people with small kidney stones to see if the procedure is safe and helps stones pass naturally. The goal is to offer a …

This trial tests a new device called VISOR for removing kidney stones. It combines stone breaking, suction, and pressure control in one tool. About 20 adults with 1-3 cm stones will undergo surgery with VISOR. The goal is to see if it clears stones safely and effectively, with a …

Urological diseases like kidney stones, prostate cancer, and bladder cancer are common but require expert diagnosis. This study will develop and test an AI assistant called UroAgent that helps doctors make decisions by analyzing patient records and images. Researchers will use 2,…

This study looks at whether it's safe to skip antibiotics before a specific type of kidney stone surgery in patients at low risk for infection. The surgery uses a special suction tool to remove stones. Researchers will compare infection rates between those who get antibiotics and…

This trial tests whether the design of a ureteral stent—a small tube that drains urine from the kidney to the bladder—affects comfort in children aged 8 to 18 undergoing staged kidney stone treatment. Each participant will receive both a standard Cook stent and a Polaris Ultra st…

This study tests whether watching a virtual reality (VR) video before kidney stone surgery can lower anxiety, boost knowledge, and improve self-care. About 90 adults scheduled for surgery will be split into three groups: standard education, standard VR, or a special VR with built…

This study compares two versions of a shockwave machine for breaking kidney stones: one with stone tracking and one without. About 126 adults with a single kidney stone (6-15 mm) will be randomly assigned to either group. The goal is to see if the tracking feature helps more peop…

This study compares four different ureteral stents (small tubes placed in the ureter) to find which one causes the fewest symptoms after laser surgery for kidney stones. About 272 adults who need a stent after stone removal will be randomly assigned to one of four stent types. Re…

This study compares a new type of ureteral stent (ComfiJ) with a standard Double-J stent in 150 adults who need a short-term stent after kidney stone surgery. The goal is to see if the ComfiJ stent causes fewer urinary symptoms, like pain or urgency, two weeks after surgery. Part…

This study compares two surgical techniques for removing bladder stones in children aged 2 to 14 years. One method uses a small cut in the belly area with a vacuum to remove stone fragments, while the other uses a scope through the urethra. The goal is to see which approach is fa…

This study compares L-citrulline, an amino acid, to tamsulosin, a standard drug, for helping adults pass kidney stones. 120 people with a single stone in the lower ureter will take one of the two treatments for up to 4 weeks. The main goal is to see which treatment leads to faste…

This study tests if a drug called aminophylline, placed directly into the bladder, can help doctors insert a small scope to remove kidney stones in children. About 60 children aged 2 to 17 with a stone in the lower ureter will take part. If the first gentle attempt to pass the sc…

This study compares two ways to use a laser to break up bladder stones in children: dusting (turning stones into fine dust) and fragmentation (breaking them into small pieces for removal). About 110 children with a single stone smaller than 3 cm will be randomly assigned to one m…

This study compares a nasal spray form of ketorolac (Sprix) to oral diclofenac pills for managing pain from ureteral stents placed after kidney stone surgery. Researchers will enroll 80 adults to see if the nasal spray provides faster pain relief and reduces unplanned doctor visi…

This study tests a new biodegradable stent (Hydrustent) that dissolves on its own after being placed in the ureter following kidney stone removal. The goal is to see if it keeps urine flowing safely and reduces the need for a second procedure to remove the stent. About 134 adults…

This study tests a new robotic system designed to help surgeons remove kidney stones. The robot controls the surgical tools and can even perform some steps on its own with AI guidance. The trial will include 15 adults with small kidney stones to see if the robot can complete the …

This study tests whether adding ear acupressure to standard painkillers helps adults with kidney stone pain feel better faster. 116 participants will receive either real ear acupressure or a sham procedure alongside an NSAID injection in the emergency room. Pain levels will be tr…

This study tests a modified double-J ureteral stent with a thinner loop at the bladder end, designed to reduce common side effects like pain, blood in urine, and discomfort. About 40 adults with kidney or ureteral stones will receive either the new stent or a standard one. Resear…

This study compares two common treatments for kidney stones that are 1 to 2 centimeters in size. One treatment uses shock waves from outside the body to break up the stone, while the other uses a thin scope and laser through the urinary tract. Researchers will measure how complet…

This study compares three common drugs—tamsulosin, solifenacin, and mirabegron—to see which one works best for reducing symptoms caused by ureteral stents placed after kidney stone surgery. About 189 adults will take one of the three pills daily and report their symptoms using a …

This study aims to find out if people who get calcium oxalate kidney stones produce more oxalate in their bodies than healthy people. Researchers will compare 80 adults—some with a history of stones and some without—after they eat a special low-oxalate diet and take small amounts…

This study aims to find out if people who get calcium oxalate kidney stones absorb more oxalate from food than healthy people. Researchers will compare stone formers and healthy volunteers by having them eat special diets and measuring oxalate in urine, blood, and stool. The goal…

This study looks back at adults who had surgery for kidney stones up to 20 mm, comparing those who had a ureteral access sheath placed during the procedure with those who did not. The goal is to see whether using the sheath affects the risk of developing a narrowed ureter or hydr…

This observational study tests a new ultrasound-based measure called the Pelvic Floor Fatigue Index (PFFI), which gauges how quickly pelvic floor muscles tire. Researchers will measure PFFI in 75 adults before they undergo ureteroscopy or retrograde intrarenal surgery for kidney …

This study looks at how the gut and kidneys work together in people with enteric hyperoxaluria, a condition that raises the risk of kidney stones. Researchers will give participants a high-oxalate diet (like spinach) and measure oxalate levels in urine and stool. The goal is to u…

This study looks at how urological diseases and their treatments impact patients' work life. Researchers will survey 2,000 adults admitted to a hospital in Poland, focusing on those having major cancer surgeries or stone procedures. Participants will be followed for 6 months to t…