Herbal extract may flush out tiny kidney stone remnants
NCT ID NCT06651294
First seen Jun 25, 2026 · Last updated Aug 11, 2026 · Updated 4 times
Summary
This study tests whether a herbal supplement called Neorenal Forte can help eliminate small leftover kidney stone fragments after laser surgery. About 120 adults with kidney stones will take either the supplement or a placebo for three months. The goal is to see if more people become completely stone-free or have only tiny fragments (2 mm or smaller) with the supplement.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Neorenal Forte (a blend of herbal extracts from birch, hernia, cranberry bush, and couch grass)
- What this could lead to
- If it works, this could offer a simple, non-surgical way to help people pass leftover kidney stone fragments after laser surgery.
- What could go wrong
- This is an early-stage trial with only 120 participants, testing a dietary supplement. The effect may be small or no better than placebo, and results may not apply to everyone with kidney stones.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 120 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Apr 2025
- Expected to finish
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Nov 2026
An estimate. End dates often move.
- Lead sponsor
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A company
The lead sponsor is a pharmaceutical, biotech, or medical-device company.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 65 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. Male or female 18 to 65 years of age. 2. The subject has signed informed consent approved by an Ethics Committee and agrees to the on-site study visits. 3. A stone confirmed by NCCT of kidney, ureter and urinary bladder for assessment of size, number, location and stone density, within 90 days of fURS. 4. Single or multiple kidney stones with total size of 10x10x10 mm to 15x10x10 mm. 5. Stone density 1001 - 1400 Hounsfield units (HU). 6. Subjects post fURS for laser lithotripsy of kidney stone. 7. Residual fragments \< 4 mm after fURS confirmed by ultrasound on first postoperative day. 8. Subjects post one fURS. 9. fURS uncomplicated by perforation of ureter, mucosal exfoliation, damage to kidney or urinary bladder, serious bleeding or other complications. 10. No recent ureterorenoscopy within the last 6 months. 11. Body mass index 17.0 - 29.99 kg/m2 118 12. In Investigator's opinion, the subject can comply with the visit schedule and the treatment regimen and is capable of completing the study. 13. The subject has a smartphone and is capable of using it. Exclusion Criteria: 1. Subjects with anatomical anomalies revealed by ultrasound - stenosis of the pyelo-ureteral junction, horseshoe kidney, kidney malrotation, calyceal diverticulum, and others. 2. Ureteral stenosis. 3. History of ipsilateral renal surgery. 4. Hydronephrosis. 5. Permanent JJ stent. 6. Any conditional or absolute contraindications for fURS. 7. Combined ipsilateral stone in the ureter or contralateral stone in the upper urinary canal or a stone in the lower urinary canal, requiring simultaneous surgery. 8. Subjects with positive urine culture, until resolution. 9. History of endourological intervention (e.g. nephrostoma, ureteral catheter) before fURS. 10. Stone density \<1000 and \>1401 HU; 11. Uncontrolled diabetes mellitus (HbA1c \>9%). 12. Renal insufficiency. 13. Subjects with arterial hypertension. 14. Subjects with prostate adenoma. 15. Allergy or hypersensitivity to any of the ingredients of the investigational product. 16. BMI ≥ 30 kg/m2. 17. Women who are pregnant or lactating; women who plan on getting pregnant during the study. 18. Alcohol or drug abuse in the last year. 19. Unstable medical conditions, as determined by the Investigator. 20. Inability to comply with the study protocol. 21. Subjects who cannot understand or not capable of completing the study documents. 22. Inability to give informed consent.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
9 sites. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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MHAT "Heart and Brain"
RECRUITINGBurgas, Bulgaria
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Military Medical Academy
RECRUITINGSofia, 1606, Bulgaria
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UMBALSM "N. I. Pirogov"
RECRUITINGSofia, 1606, Bulgaria
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UMHAT "Alexandrovska"
RECRUITINGSofia, 1431, Bulgaria
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UMHAT "Dr. Georgi Stranski"
RECRUITINGPleven, 5800, Bulgaria
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UMHAT "Sofiamed"
RECRUITINGSofia, 1797, Bulgaria
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UMHAT "St. George"
RECRUITINGPlovdiv, 4000, Bulgaria
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UMHAT Kaspela
RECRUITINGPlovdiv, 4001, Bulgaria
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University Hospital for Active Treatment "Saint Marina"
RECRUITINGPleven, 5800, Bulgaria
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Three ways to clear a blocked kidney: which works best?
- Two routes to clear bladder stones: which surgery works better?
- Can a blood pressure drug make kidney stone surgery safer?
- Which kidney stone surgery is safer for your ureter? a large study investigates
- A simple ultrasound test might predict who suffers most from stent pain
- Can a simple tool predict who will be Stone-Free after kidney surgery?