Ulcer of lower limbs

This study tests a special stent (a small mesh tube) placed in veins to treat blockages, narrowing, or leg ulcers caused by poor blood flow. About 150 adults will receive the stent and be followed to see if it keeps the vein open and safe. The goal is to improve blood flow and re…

This trial is testing whether adding a special wound matrix (OCM) to standard compression and routine care helps heal venous leg ulcers better than standard care alone. Adults with a venous leg ulcer will be randomly assigned to receive either the OCM plus standard care or standa…

This study tests whether using ultrasound to push propolis (a natural bee product) into the skin can help heal diabetic foot ulcers faster. Eighty adults with diabetes and foot ulcers will either get propolis plus ultrasound or standard wound care for 4 weeks. The goal is to see …

This phase 2 trial tests a gel called EscharEx, made from pineapple enzymes, on people with venous leg ulcers that have stubborn dead tissue. The gel is applied to the wound to break down and remove non-viable tissue, potentially speeding up healing. The study involves 20 adults …

This study tests if a special wound dressing called MIRRAGEN® can help heal venous leg ulcers (open sores on the legs caused by poor blood flow) faster than standard care alone. About 110 adults with these ulcers will either get MIRRAGEN® plus standard care or standard care only.…

This early-stage trial tests a gel called LUT017 on chronic wounds like venous leg ulcers. The gel is applied once a week for up to 8 weeks to see if it's safe and might help wounds heal. About 12 to 18 adults with a leg wound that hasn't healed for at least 4 weeks will take par…

This study compares two types of compression bandages for treating venous leg ulcers, which are slow-healing wounds on the lower leg. About 386 adults will receive either the new Mepi Press 2 or the standard UrgoK2 bandage for up to 12 weeks. The goal is to see if the new bandage…

This phase 1/2 trial tests whether a patient's own stem cells, taken from belly fat and grown in a lab, can heal leg ulcers caused by severe peripheral artery disease. 40 participants will either receive stem cell injections and a special cell-containing dressing, or standard hyd…

This pilot study tests whether injecting dexpanthenol (a vitamin B5 derivative) under the skin around chronic wounds can help them heal faster. 40 adults with diabetic foot ulcers, venous leg ulcers, or arterial ulcers will receive either standard wound care alone or standard car…

This study tests whether a special wound covering made from donated human placental tissue, called NeoThelium FT, can help heal venous leg ulcers when used with standard care. About 132 adults with open leg ulcers that haven't healed well will be randomly assigned to get either t…

This study tests whether adding FoundationDRS Solo to usual wound care helps heal chronic foot ulcers in people with diabetes. About 124 adults with a nonhealing ulcer will get either the new treatment plus standard care or standard care alone for 12 weeks. The main goal is to se…

This study tests whether special dressings made from donated human umbilical cord tissue, used along with standard wound care, can help close hard-to-heal leg ulcers faster than standard care alone. About 272 adults with venous leg ulcers that have not healed after 4 to 52 weeks …

This study tests whether two skin substitutes made from donated human umbilical cord tissue can help close hard-to-heal diabetic foot ulcers. About 272 adults with diabetes and a foot ulcer will receive either standard wound care alone or standard care plus weekly applications of…

This study tests whether adding cold atmospheric plasma (CAP) to standard wound care helps diabetic foot and venous leg ulcers heal faster and stay healed longer. About 494 adults with these chronic wounds will receive either standard care alone or standard care plus CAP. The goa…

This Phase 3 trial will test whether a graft made from donated amniotic tissue can help heal chronic wounds like diabetic foot ulcers and venous leg ulcers better than standard care. About 600 adults with wounds that haven't healed in 4 weeks will take part. The study will measur…

This trial is testing a soft silicone foam dressing called Mepilex Up on adults with leg or foot ulcers and skin tears. The goal is to see if the dressing helps wounds progress toward healing and is safe to use. About 70 participants will use the dressing for up to 6 weeks, and d…

This trial tests whether a structured, supervised exercise program that activates the calf muscle pump can improve healing of venous leg ulcers compared to standard advice to walk at home. The study involves adults aged 20 to 60 with non-healing ulcers, and it measures changes in…

This study tests a new 'smart bandage' that checks wound moisture, temperature, and acidity, then sends updates to a nurse's app. About 110 adults with hard-to-heal leg ulcers will either get the smart bandage plus standard care or standard care alone. The goal is to see if the s…

This study compares Vashe solution, a wound cleanser, to standard saline for treating leg ulcers that show signs of heavy bacterial infection. About 102 adults with venous or mixed leg ulcers will be randomly assigned to one of the two solutions. The goal is to see if Vashe reduc…

This study tests a new system called Tight Alright that uses a small wearable device under bandages to measure pressure on leg ulcers. The device sends real-time pressure data to a mobile app and healthcare team, helping ensure the right pressure is applied for healing. About 40 …

This pilot study will check if it's possible to collect useful nutrition and health information from 30 adults with diabetic foot ulcers. Researchers want to see if they can recruit enough people and gather complete data. The goal is to learn about patients' diet, body compositio…