Thyroid gland carcinoma

This study tests an experimental oral drug called S241656 (BDTX-4933) in people with advanced solid tumors that have certain genetic changes (KRAS, BRAF, or other RAS/MAPK mutations). The trial has two parts: first, finding a safe dose, then testing how well it works alone or wit…

This study tests a device that uses nanosecond electrical pulses to destroy small papillary thyroid cancers (up to 1.5 cm) without cutting the skin. Fifteen participants will get the outpatient procedure under local anesthesia. The main goal is to check safety and side effects, n…

This study tests two drugs, sacituzumab tirumotecan and tislelizumab, in people with advanced thyroid cancer that has stopped responding to standard treatments. The goal is to see if these drugs can shrink tumors or help people live longer. About 94 adults with three types of har…

This study compares two doses of the drug lenvatinib (24 mg vs 10 mg daily) in 34 people with advanced thyroid cancer that no longer responds to radioactive iodine. The goal is to see if the lower dose causes fewer side effects while still controlling the cancer. Participants tak…

This study tests a new PET scan using a special form of iodine called iodine-124 to measure how much radioactive iodine thyroid cancer tumors absorb. The goal is to help doctors decide if standard radioactive iodine therapy is likely to help. About 60 adults with metastatic thyro…

This study tests a new imaging method called vibro-acoustography (VA) to find and tell apart harmless and cancerous thyroid nodules. Researchers at Mayo Clinic will compare VA images to standard ultrasound in 650 people aged 8 and older who are at risk for thyroid cancer. The goa…

This study tests whether adding contrast-enhanced ultrasound to standard ultrasound can improve the diagnosis of thyroid cancer. Researchers are comparing two scoring methods in 800 participants with thyroid nodules. The goal is to see which method better identifies cancer and re…

This study is testing whether a blood test can diagnose thyroid cancer as accurately as a traditional biopsy. Researchers will analyze tiny particles called extracellular vesicles from blood and tissue samples of 250 adults with thyroid nodules or cancer. The goal is to find a le…

This study is testing a new DNA-based method to determine whether thyroid nodules are cancerous or benign. Researchers will analyze tissue from needle biopsies of 1,450 adults to see if the test can accurately tell cancer from harmless growths. The goal is to reduce the number of…

This trial tests whether a non-invasive technique called TENS-WAA, which uses mild electrical pulses on the wrist and ankle based on acupuncture principles, can reduce pain after thyroid surgery. It involves 668 adults who have just had thyroid surgery and are experiencing modera…

This study tests whether adding cryoablation (a procedure that freezes and kills cancer cells) to standard radiation therapy provides better pain relief for people whose cancer has spread to their bones. About 40 participants with various cancers will be split into two groups: on…

This study collects blood and tissue samples from 2000 people—some with cancer and some without—to create a blinded reference set. Researchers will use these samples to evaluate how well new blood tests can detect many types of cancer early. The goal is to improve the accuracy of…

This study tests whether a special type of MRI, called hyperpolarized MRI, can predict how well thyroid and head/neck cancers respond to radiation or drug therapy before surgery. About 42 participants will get this imaging scan before and after starting treatment. The goal is to …

This study follows children who had radiation therapy for cancer to see how often they develop thyroid nodules or thyroid cancer. Researchers will compare them to children who did not have radiation, looking for risk factors and genetic clues. The goal is to create better screeni…

This study looks at how changing thyroid hormone levels affect the way the body uses sugar and fat. Researchers will study people with Graves' disease (whose thyroid hormones are too high) and people with thyroid cancer (whose hormones are intentionally raised). Participants will…

This study looks back at 1,200 people who had a breathing tube placed during surgery to find out how often voice box injury happens and what makes it more likely. Researchers will check medical records and call patients to see if they had hoarseness or other throat problems after…