Pulmonary tuberculosis

Researchers in India are studying whether a 4-month daily regimen that includes moxifloxacin can cure newly diagnosed, microbiologically confirmed pulmonary tuberculosis as effectively as the standard 6-month treatment. The study enrolls 550 adults aged 18 to 65 who have not yet …

This study tested an experimental vaccine called H56:IC31 in 831 adults who had just finished treatment for tuberculosis (TB). The goal was to see if the vaccine could lower the chance of TB coming back. Participants were randomly assigned to get either the vaccine or a placebo, …

This trial tests an experimental antibiotic called BTZ-043 in adults with newly diagnosed, drug-sensitive pulmonary tuberculosis. Participants take the drug by mouth once daily for 14 days, and researchers compare it to a standard combination treatment. The main goal is to check …

This trial tests a new combination of four drugs, called BPaMZ, for treating tuberculosis. People with drug-sensitive TB receive BPaMZ for 4 months, compared to the standard 6-month regimen. People with drug-resistant TB receive BPaMZ for 6 months. The study measures how well the…

This trial compares the antibiotic rifapentine against the standard drug rifampin during the first 8 weeks of treatment for pulmonary tuberculosis. About 334 adults with TB bacteria in their sputum are randomly assigned to receive either the standard regimen or one with rifapenti…

This trial tested a new 4-month combination of three drugs (OPC-167832, delamanid, and bedaquiline) against the standard 6-month treatment for drug-susceptible pulmonary tuberculosis. 122 adults with newly diagnosed TB took part. The goal was to see if the shorter regimen is safe…

This study looked at whether adding metformin, a diabetes drug, to standard tuberculosis (TB) treatment is safe and tolerable for people also living with HIV. 112 adults with TB and HIV took either standard TB medicines alone or with metformin for 11 weeks. Researchers monitored …

This study tested whether taking a double dose of the HIV drug dolutegravir (50 mg twice daily) along with the TB drug rifapentine can keep HIV under control in people with both HIV and tuberculosis. Thirty adults participated. The goal was to see if the higher dose is safe and e…

This study tested an experimental drug called GSK3036656 in combination with other tuberculosis medications in 127 adults with newly diagnosed, drug-sensitive pulmonary TB. Participants received one of several two-drug combinations or standard care for 14 days, then switched to s…

This study tested two different doses of the antibiotic linezolid, combined with three other drugs (bedaquiline, delamanid, and clofazimine), in 138 people with drug-resistant pulmonary tuberculosis. The goal was to see which dose worked better at clearing the infection and was e…

This study tested a therapeutic vaccine called RUTI in 41 adults with active pulmonary tuberculosis. Participants received either the vaccine or a placebo alongside their regular antibiotic treatment. The goal was to see if the vaccine could boost the immune system to kill bacter…

This study tested a therapeutic vaccine called RUTI in 140 people with tuberculosis (TB), including drug-resistant forms. Participants received either one dose of RUTI or a placebo alongside their standard TB medications. The goal was to see if the vaccine could help clear the TB…

This study tested two different antibiotics—clarithromycin or moxifloxacin—alongside standard drugs to treat a rare lung infection caused by M. xenopi bacteria. Researchers tracked whether patients' sputum samples became bacteria-free after 6 months. The goal was to find the more…

This study tested a new HIV medication (Biktarvy) taken twice daily in 122 adults who also have drug-sensitive tuberculosis (TB) and are on standard TB treatment. The goal was to see if the new pill can control HIV just as well as the current standard treatment. The study measure…

This phase IIb trial tested an experimental antibiotic called delpazolid, added to a standard three-drug regimen (bedaquiline, delamanid, moxifloxacin), in 76 adults with newly diagnosed, drug-sensitive pulmonary tuberculosis. The main goals were to check safety and how the drug …

This completed trial tested whether zinc and selenium supplements could boost the immune system of tuberculosis patients. Researchers gave 90 adults with pulmonary TB either fortified cookies or a supplement called Myrin P Fort, and measured changes in body measurements, blood co…

This study tested a combination of three drugs—bedaquiline, pretomanid, and linezolid—in 109 people with extensively drug-resistant TB (XDR-TB) or multi-drug resistant TB (MDR-TB) that didn't respond to other treatments. Participants took the drugs for 6 to 9 months. The goal was…

Researchers are testing a portable device called Truenat MTB Plus/COVID-19 to see if it can accurately detect both tuberculosis and COVID-19 from the same sample. The study will enroll about 2,000 adults who have symptoms like a long-lasting cough, fever, or weight loss, which co…

This study evaluates whether two newer line probe assays, the YD REBA MTB-MDR and Hain Genotype MTBDRplus V2, perform as well as the older Hain Genotype MTBDRplus V1 in detecting drug-resistant tuberculosis. Researchers will test stored, de-identified samples from adults with sym…

This study tests whether an enhanced diagnostic workup can identify lung diseases other than tuberculosis in patients who are about to start TB treatment based on clinical signs but have negative sputum tests. Participants will undergo a thorough review and possibly additional te…

This study evaluates a rapid viability test for tuberculosis bacteria in sputum samples. The goal is to see if this test can accurately tell whether a patient is still contagious, compared to the standard culture method that takes weeks. If the test works, it could help doctors d…

This study tested a new rapid blood test called SeroSelectTB to see if it can diagnose active tuberculosis (TB) faster than current methods. Over 9,000 adults in South Africa, Tanzania, and Ethiopia who were unwell and suspected of having TB or pneumonia took part. The goal is to…

This study evaluated a new stool-based test (qPCR) to diagnose tuberculosis (TB) in children under 8 and people living with HIV. Researchers in Mozambique, Eswatini, and Uganda tested nearly 2,000 participants to see if the stool test could improve TB detection rates compared to …

This study looked at whether a bronchoscopy (a thin, flexible tube with a camera) can help diagnose tuberculosis in the airways of people whose usual sputum tests came back negative. 63 adults with suspected lung TB took part. The goal was to catch the disease earlier and more ac…

This study tested two new tools for diagnosing tuberculosis (TB): a software that analyzes chest X-rays (CAD4TB) and a blood test that measures C-reactive protein (CRP). Researchers enrolled 1,400 adults with TB symptoms in Lesotho and South Africa. They compared these tests to s…

This study tested whether a supervised exercise program can improve heart and lung function and quality of life in people with lasting lung damage from tuberculosis. 60 participants were split into an exercise group and a control group. The goal was to see if physical training he…

This completed Phase 3 study measured how high doses of the tuberculosis drugs rifapentine and moxifloxacin move through the body in 53 adults with TB. Participants gave multiple blood samples to track drug levels. The goal was to understand the best doses to kill TB bacteria whi…

This study compares two strategies for finding undiagnosed tuberculosis (TB) in peri-urban Uganda. One strategy sets up screening at a large health clinic, while the other sends mobile screening teams into local hotspots where TB is thought to be most common. Researchers will tra…

This pilot study aims to test the feasibility of creating a large-scale cohort of tuberculosis (TB) patients in northern Paris, an area with high TB rates. Researchers will collect blood samples and clinical data from 30 participants over the course of their treatment to understa…

This study tested whether a virtual reality (VR) room called VR CAVE can teach community health nursing skills as effectively as a physical mock home. 150 final-year nursing students practiced home visits for patients with COPD and tuberculosis in both settings. Results showed bo…

This study looked at whether providing nutritional support to people being treated for tuberculosis (TB) improves their outcomes. Researchers compared TB patients in Benin, who receive food baskets and meals, to similar patients in Togo, who do not get systematic nutritional supp…

This completed study looked at 141 people being treated for tuberculosis (TB) to see if intestinal parasites or poor nutrition made their recovery harder. Researchers checked stool samples for parasites and measured weight gain and treatment success. Some participants received nu…