Breakthrough TB cocktail cures Drug-Resistant cases in just 6 months

NCT ID NCT02333799

Completed Disease control Sponsor: Global Alliance for TB Drug Development Source: ClinicalTrials.gov ↗

First seen Nov 01, 2025 · Last updated May 20, 2026 · Updated 25 times

Summary

This study tested a combination of three drugs (bedaquiline, PA-824, and linezolid) in 109 people with highly drug-resistant tuberculosis (TB) who had few other options. After 6 months of treatment (extended to 9 months if needed), the goal was to see if the infection could be cleared and stay gone. The approach aimed to offer a shorter, more effective treatment for a disease that normally requires years of harsh therapy.

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Contacts and locations

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Locations

King DinuZulu Hospital Complex

Sydenham, Durban, 4001, South Africa
Sizwe Tropical Disease Hospital

Sandringham, Johannesburg, 2131, South Africa
Task Applied Science - Brooklyn Chest Hospital

Ysterplaat, Cape Town, 7405, South Africa

Conditions

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PULMONARY TUBERCULOSIS