Pulmonary edema

This trial tests whether ECMO, a machine that temporarily takes over heart and lung function, can safely help adults with respiratory failure who are not improving with standard care. Researchers will enroll 30 patients with high carbon dioxide levels and low blood pH, including …

This study tested whether giving heart failure patients with fluid in their lungs a lower oxygen target (90% oxygen saturation) or a higher one (96%) leads to better outcomes. 122 patients were randomly assigned to one of the two groups in the emergency department. The goal was t…

This study tested whether an extended-release version of the diuretic torsemide helps heart failure patients get rid of more salt after lunch compared to the standard immediate-release version. Twenty adults with stable heart failure took both forms in a random order, and researc…

This study tests whether a new device that records chest vibrations from a distance can detect heart and lung diseases. Researchers will compare the vibration patterns of people with known cardiac or pulmonary conditions to those of healthy volunteers. If the technique works, it …

This study tested whether measuring a protein called Clara cell protein 16 (CC16) in the blood can help doctors tell the difference between two types of lung fluid buildup: one caused by heart problems and another caused by lung injury. Researchers measured CC16 levels in 100 ICU…

This study compared two breathing devices—CPAP and bilevel ventilation—in people with severe fluid buildup in the lungs (pulmonary edema). The goal was to see which device improves breathing faster. Participants were adults in respiratory distress. The results could help doctors …

This study tested whether a computer-driven system called Smartcare/PS could help children with respiratory failure come off a breathing machine faster than usual care. Thirty children were enrolled, and the system automatically adjusted breathing support based on each child's ne…

This study tested whether critically ill patients on breathing machines could safely manage their own sedation using a button-controlled device. 161 adults in the ICU were randomly assigned to either self-manage their sedation or have it managed by a nurse. The goal was to see if…

This study looks at whether adults with acute respiratory failure who need non-invasive ventilation (a breathing mask) are getting enough calories and protein. Researchers will track what each patient eats for five days after starting ventilation and compare it to recommended tar…

This study watches how a high-frequency ventilator (Servo-n HFOV) works in real hospital use for babies with severe breathing failure. About 75 infants will be observed to see if the machine safely helps them get enough oxygen and remove carbon dioxide. The goal is to gather info…

This study looks at how breathing machines (mechanical ventilators) might injure the diaphragm, the main muscle used for breathing. Researchers will monitor 50 ICU patients over their first 7 days on the ventilator, measuring diaphragm activity and function. The goal is to unders…

This study looked at the experiences of 126 people in Denmark who rely on a breathing machine at home, along with their families and the trained caregivers who help them. The goal was to understand the challenges and successes of this life-sustaining care. No new treatments were …

This study looked at 500 adults on breathing machines to see if measuring airway pressure at a specific moment (P1) versus a later moment (P2) better predicts lung damage. The goal is to find which measurement helps doctors set safer ventilator settings. No new treatment was test…

This study observed over 4,000 patients in Chinese ICUs who needed breathing support for acute respiratory failure. Researchers tracked treatments, outcomes, and costs to better understand the disease burden. The goal is to improve care and identify risk factors, not to test a ne…

This pilot study tested three common ventilator modes—volume control, pressure control, and adaptive pressure control—in 566 ICU adults with respiratory failure. The goal was to see which mode leads to more days alive and off the ventilator. The study is a first step to guide fut…

This University of Oxford study looked at 48 ICU patients on ventilators for respiratory failure. Doctors sometimes inflate the lungs briefly (a recruitment manoeuvre) to reopen collapsed areas, but it's unclear when this helps. Researchers used a device to measure lung volume an…

This study looked at 609 adults who completed an open-water swimming race and had no breathing problems. Researchers used lung ultrasound to check for extra fluid in the lungs. The goal was to find out how common hidden lung water is in swimmers who feel fine.

This study looked at whether measuring tiny brain signals during a breathing test can help predict if a patient on a ventilator will successfully breathe on their own. Researchers monitored 70 intubated adults as they tried breathing without the machine. The goal is to find a sim…

This study surveyed 534 physicians worldwide to understand how they use humidification (adding moisture to air) when treating hospitalized adults with non-invasive ventilation (breathing support through a mask). The goal was to find out how often humidification is used, what type…

This study looked at 24 critically ill patients on breathing machines to see how changing the machine's settings affects measurements of breathing effort. Researchers compared a simple bedside measurement with a more invasive gold-standard technique. The goal was to find the best…