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Oxygen showdown: tight vs. liberal targets in heart failure

NCT ID NCT05613218

Disease control Sponsor: Copenhagen University Hospital, Hvidovre Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether giving heart failure patients with fluid in their lungs a lower oxygen target (90% oxygen saturation) or a higher one (96%) leads to better outcomes. 122 patients were randomly assigned to one of the two groups in the emergency department. The goal was to see which oxygen level reduces fluid in the lungs and improves recovery.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Oxygen
What this could lead to
If it works, this could help doctors choose the best oxygen level for heart failure patients, potentially improving recovery and reducing hospital stays.
What could go wrong
This is a small pilot study with only 122 patients, so results may not apply to everyone. The oxygen targets are narrow, and the study may not find a clear benefit or harm.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2/3

Runs two stages together: whether the treatment works, then large-scale confirmation.

Participants

122 people

The number who actually took part.

Started

Feb 2024

Finished

Mar 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Age ≥ 18 years 2. Acute (within minutes to days) onset or worsening of subjective dyspnea 3. Oxygen saturation \<92% (on arterial blood gas) or need of oxygen 4. At least one of the following clinical or radiological signs of congestion: 1\. Pulmonary rales 2. Chest X-ray or CT with pulmonary congestion 3. Lung ultrasound with multiple B-lines Exclusion Criteria: 1. More than 4 hours from hospital admission to randomization 2. Suspected infection or sepsis 3. Known severe pulmonary disease 4. Systolic blood pressure \<90 mmHg

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Conditions

The condition(s) this trial relates to.

heart failure Hypoxia pulmonary edema

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Acute heart failure Hypoxemia Pulmonary congestion

Contacts and locations

Locations

  • Amager-Hvidovre Hospital

    Copenhagen, 2650, Denmark

  • Bispebjerg Hospital

    Copenhagen, 2200, Denmark

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