Polyp of large intestine

This study compares two methods for finding precancerous colon polyps during colonoscopy. Both methods use water instead of air to inflate the colon and an AI system to spot polyps. One group also uses a special light filter called linked-color imaging. The goal is to see if the …

This study tests whether adding a hot tool to the standard cold removal of large colon polyps lowers the chance of polyps growing back. About 194 adults with flat or slightly raised polyps at least 20 mm wide will be randomly assigned to one of two procedures. Participants will h…

This study is testing whether a special milk called UNICLA-A2 can reduce inflammation and improve gut health in people at high risk for colorectal cancer who have already had polyps removed. The milk comes from cows with a specific protein type and is enriched with omega-3 and se…

This study tests whether a 6-month diet change can reduce inflammation and improve metabolism in obese adults who have had colon polyps. Participants and their household partners will follow a special eating plan. The goal is to see if diet can lower the risk of developing colore…

Researchers are comparing a fully autonomous artificial intelligence system with AI-assisted human diagnosis for identifying colorectal polyps during colonoscopy. The trial enrolls 540 adults scheduled for full colonoscopy, excluding those with inflammatory bowel disease, active …

This study is exploring whether molecular clues in stool and saliva samples can predict the presence of colorectal polyps. About 1,000 adults scheduled for a colonoscopy will provide samples beforehand, which will be analyzed and compared with their colonoscopy results. The goal …

This trial tests whether a 3D imaging device used during colonoscopy helps doctors find high-risk adenomas—polyps that could turn into cancer—better than the usual 2D view. Adults aged 18-75 scheduled for a diagnostic colonoscopy will be randomly assigned to either a 2D or 3D sco…

This study compares two ways to monitor older adults (ages 65-82) who have had colon polyps in the past: an annual stool test (FIT) or a colonoscopy every few years. About 9,000 participants will be randomly assigned to one of the two methods and followed for up to 11 years to se…

This study is testing a new blood test called DENEB that looks for tiny molecules (microRNAs) to find colorectal cancer and precancerous polyps early. Researchers will collect blood samples from 2,000 people who are also getting a colonoscopy. The goal is to see if the blood test…

This study tests a tool called SCALE-EYE that helps doctors measure the size of polyps during a colonoscopy. The goal is to see if it works better than current methods and can reduce the number of follow-up colonoscopies, waste, and carbon footprint. About 241 people aged 55-80 h…

This study tests a new microwave-based device, called MiWEndo, that is used during a standard colonoscopy to help doctors find polyps in the colon. About 50 people who already have a polyp in their rectum will take part. The goal is to see if the device is safe and can find more …

This study tests different amounts of exercise to see if it can prevent colorectal polyps from returning in people with Familial Adenomatous Polyposis (FAP). About 32 participants will follow a personalized treadmill program at home for 26 weeks. Researchers will check how well p…

This study tests whether a device called GelPOINT® Path can improve the removal of colorectal polyps during a procedure known as endoscopic submucosal dissection (ESD). The device is designed to give doctors better access, stable air pressure, and clearer views inside the colon. …

This study tests a new gel called SUBMO® to see if it works as well as the standard saltwater solution for lifting and removing large colon polyps (over 10 mm) during a colonoscopy. About 300 adults will take part. The goal is to make the removal process smoother and safer.

This study tests a new device called GripTract-GI for removing complex colon polyps. It compares the device to the usual method in 30 adults. The goal is to see if it reduces complications, shortens procedure time, and allows for complete removal in one piece.

This study looks at whether using lower pressure gas during laparoscopic large bowel surgery can protect the gut and help patients recover faster. About 125 adults having certain types of colon surgery will be randomly assigned to different pressure levels. The goal is to see if …

This study tests whether a technique called cold snare polypectomy can safely remove 10-20 mm colon polyps without using heat. About 120 adults will have their polyps removed this way during a colonoscopy. The goal is to see if it works well and causes fewer complications than tr…

This study tests a simple web-based tool that helps doctors predict whether a large colon polyp contains invasive cancer. The tool uses only standard endoscopic images and basic information like polyp size and location. Doctors of varying experience will use the tool to assess po…

This study follows 3,500 adults with large colon polyps (20 mm or bigger) to see how well current removal methods work. Doctors will record details about the patients, polyps, and procedures. The goal is to learn what leads to successful removal without surgery and to track any c…

This study looks at the genes in colon polyps from people with MASH (a type of fatty liver disease) compared to those without fatty liver. Researchers want to find specific gene patterns that might signal higher risk. About 100 adults already scheduled for polyp removal will dona…

This study is testing a new device that uses small electric pulses to destroy colon polyps during a colonoscopy. Researchers want to see if it is safe and effective for removing polyps. Thirty adults with at least one polyp larger than 5mm in the lower colon will be enrolled. The…

This study tests whether a digital training program called Colo-ID helps doctors better predict the type of colon polyps they see during a colonoscopy. About 1,500 adults with at least one polyp will take part. Doctors will record their predictions before and after training, and …

This study collects images and videos of large colon polyps from 5,000 people undergoing colonoscopy. The goal is to train an artificial intelligence system to automatically predict whether a polyp has invaded deeper layers of the bowel wall. No drugs or treatments are tested—onl…

This study looks at how adding beans to the diet affects bowel and metabolic health in 25 overweight adults aged 30-80 who are scheduled for a colonoscopy. Participants will drink a bean smoothie for two weeks, and researchers will measure changes in gut bacteria, blood markers, …

This study tests whether a short video training can improve doctors' ability to detect cancer recurrence at colonoscopy scars. 141 endoscopists of all experience levels will view 15 images before and after a learning tool, answering questions about scar recognition and recurrence…

This study is collecting data from 1,200 people across France who are having a procedure called endoscopic submucosal dissection (ESD) to remove large polyps or early cancers from the colon. ESD allows doctors to remove the entire lesion in one piece, which helps with accurate an…