Zapping polyps away: electric pulses could replace surgery
NCT ID NCT06317727
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study is testing a new device that uses small electric pulses to destroy colon polyps during a colonoscopy. Researchers want to see if it is safe and effective for removing polyps. Thirty adults with at least one polyp larger than 5mm in the lower colon will be enrolled. The main goal is to check for side effects like bleeding or pain, and to see if polyps come back.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Irreversible electroporation via EndoVE device and ePORE generator
- What this could lead to
- If successful, this could offer a new, less invasive way to remove colon polyps during a routine colonoscopy.
- What could go wrong
- This is a very early pilot study with only 30 people, so results may not apply to everyone. Risks include bleeding, pain, or bowel perforation.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Participants
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About 30 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Mar 2025
- Expected to finish
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Feb 2028
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
Consenting adults with endoscopically confirmed colorectal polyps who fit the inclusion criteria.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * \> 18 years of age. * Ability to review the consent form prior to enrolment into the study • Patients must be mentally capable of understanding the information given • Patients must give written informed consent prior to undergoing any study-specific procedures. * Patients must have at least one polyp (treatment naive, recurrent or residual) measuring \>5mm, located distal to the splenic flexure(i.e descending colon, Sigmoid colon, recto sigmoid junction and the rectum above the dentate line) * Polyp(s) must be classified as Type 1 or Type 2, based on NICE (Narrow Band Imaging International Colorectal Endoscopic) classification; OR Type 1 or Type 2A /2B based on JNET (Japan Narrow Band Imaging Expert Team) classification * Patients must have a World Health Organization (WHO) performance status ≤ 2 . Patients must have a life expectancy of at least 6 months Exclusion Criteria: * \< 18 years of age. * Patients who are incapacitated, unconscious or from a vulnerable population. • Patient who is pregnant or breastfeeding * Patients unable to provide their own informed consent * Patients with complex / challenging polyp(s), including but not limited to those that are: o \>20mm in size o Flat/bulky in shape o Extending beyond 2 haustra folds or occupying more than 1/3rd of the lumenal circumference o Located on the right colon proximal to the splenic flexure, ileocecal valve, hepatic and splenic flexure or dentate line of the rectum o Fibrosis from large lateral spreading lesions * Patients with NICE Type 3 category polyps, OR JNET Type 3 polyps OR Kudo Vi pit pattern polyps * Patients with British Society of Gastroenterology (BSG) category C (high risk polyps). * Five or more polyps in a single patient * Grossly inflamed colonic mucosa with bleeding or ulcers * Implanted colonic stents * Polyposis syndromes
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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King's College Hospital
RECRUITINGLondon, SE5 9RS, United Kingdom
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