Could a glass of special milk help prevent colon cancer?

NCT ID NCT04824053

Disease control Sponsor: Instituto de Investigación Sanitaria Aragón Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study is testing whether a special milk called UNICLA-A2 can reduce inflammation and improve gut health in people at high risk for colorectal cancer who have already had polyps removed. The milk comes from cows with a specific protein type and is enriched with omega-3 and selenium. Over 3 months, 34 participants will drink either this special milk or regular milk to see if it lowers inflammatory markers and supports a healthier gut microbiome.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance: UNICLA-A2 milk (from cows with A2 beta-casein, enriched with omega-3 and selenium)
What this could lead to: If it works, this could point toward a dietary approach to lower inflammation and cancer risk in people who have had colon polyps removed.
What could go wrong: This is a small, early-phase trial with only 34 participants, so results may not apply widely. The intervention is just a dietary supplement, so any effect is likely modest.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 34 people

The number the study aims to enrol. It can still change while the study runs.

Started

Feb 2022

Expected to finish

Dec 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 80 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Participants diagnosed with high-risk polyps in the colorectal cancer screening programme or in the relative's colon cancer prevention program or patients who are in follow-up due to prior detection of polyps with any of the following characteristics: * At least 10 adenomas * At least 5 proximal serrated polyps (PSP) * At least 2 serrated polyps with diameters ≥10 mm * Serrated Polyposis Syndrome (SPS) * Early invasive CRC (stage pT1) endoscopically resected (surgery not required) * A sessile or flat lesion ≥ 20 mm with fragmented resection * Patients with previous resection of polyps in which the resection margin was not assessable and are considered susceptible to repeat colonoscopy * Patients with intramucosal carcinoma in situ or invasion of the lamina propria (pTis) 2. Regular consumer of milk and dairy products. 3. Informed consent form signed. Exclusion Criteria: 1. History of allergic reaction attributed to compounds of similar chemical composition to the study agents. 2. Incomplete colonoscopy or with poor quality criteria, Boston \<6. 3. Concomitant acetylsalicylic acid (ASA), NSAIDs, misoprostol, corticosteroids or statins needed on a regular or predictable basis during the time of the study. 4. Previous gastrointestinal surgery (colon or small intestine or gastric) that affects the absorption of nutrients. 5. History of familial adenomatous polyposis.

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Conditions

The condition(s) this trial relates to.

Inflammation polyp polyp of large intestine colorectal cancer prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Colorectal polyp

How to take part

Only the study team decides who joins. These are the ways to reach them.

The places running it

1 site. The list below names each one and where it is.
The official record

ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

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A doctor treating you

A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Could a glass of special milk help prevent colon cancer?

What the study statuses mean