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Cold vs. hot snare: which is better for removing colon polyps?

NCT ID NCT05545787

Disease control Sponsor: Qingwei Jiang Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This study compared two methods for removing non-cancerous colon polyps that are 10-19 mm in size: cold snare (no heat) and hot snare (uses heat). 216 adults undergoing colonoscopy were randomly assigned to one method. The goal was to see if cold snare is as effective and safe as hot snare for complete removal.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
cold snare endoscopic mucosal resection and hot snare endoscopic mucosal resection
What this could lead to
If successful, this could show that cold snare removal is just as effective as hot snare but with fewer risks, improving colon polyp treatment.
What could go wrong
This is a completed trial with 216 participants, but results may not apply to larger polyps or other populations. Both procedures carry risks like bleeding or perforation.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

216 people

The number who actually took part.

Started

Oct 2022

Finished

Apr 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 80 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * 18-80 years of age; * undergo colonoscopy in the Digestive Endoscopy Center of Peking Union Medical College Hospital, Beijing Tsinghua Changgung Hospital or Seventh Medical Center, General Hospital of the Chinese People's Liberation Army; * volunteer to participate in this study and sign informed consent; * at least one polyp sized 10-19 mm (Paris classification Is or IIa) by colonoscopy. Exclusion Criteria: * American Society of Anesthesiologists (ASA) status class 3 or above; * poor bowel preparation (Boston bowel preparation scale \< 6 points); * known or endoscopic features indicating the submucous infiltration or malignancy; * oral anti-coagulants, or antiplatelet agents, or known blood coagulation disorders, or bleeding tendency (platelets\<50000 cells/mm3 or INR\>1.5); * a history of colorectal resection; * emergency colonoscopy (hemodynamic instability and/or continued active gastrointestinal bleeding and/or requiring intensive care patients); * inflammatory bowel disease, familial polyposis, and colorectal cancer; * pregnancy or lactation; * severe cardiopulmonary dysfunction, liver cirrhosis, chronic kidney disease, other malignant tumors, or severe infectious diseases.

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Conditions

The condition(s) this trial relates to.

polyp of large intestine

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Colorectal polyp

Contacts and locations

Locations

  • Beijing Daxing District People's Hospital

    Beijing, Beijing Municipality, 102600, China

  • Beijing Dongcheng District First People's Hospital

    Beijing, Beijing Municipality, 100010, China

  • Beijing Fangshan District Liangxiang Hospital

    Beijing, Beijing Municipality, 102401, China

  • Beijing Sixth Hospital

    Beijing, Beijing Municipality, 100191, China

  • Beijing Tsinghua Changgung Hospital

    Beijing, Beijing Municipality, 102218, China

  • Emergency General Hospital

    Beijing, Beijing Municipality, 100028, China

  • Henan Provincial People's Hospital

    Zhengzhou, Henan, 450003, China

  • PLA Western Theater General Hospital

    Chengdu, Sichuan, 610083, China

  • Peking Union Medical College Hospital

    Beijing, Beijing Municipality, 100730, China

  • Seventh Medical Center, General Hospital of the Chinese People's Liberation Army

    Beijing, Beijing Municipality, 100700, China

  • The Affiliated Hospital of Qingdao University

    Qingdao, Shandong, 266005, China

  • The First Affiliated Hospital of Chongqing Medical University

    Chongqing, Chongqing Municipality, 400016, China

  • The First Affiliated Hospital of Nanchang University

    Nanchang, Jiangxi, 330006, China

  • The First Hospital of Shanxi Medical University

    Taiyuan, Shanxi, 030001, China

  • West China Longquan Hospital, Sichuan University

    Chengdu, Sichuan, 610041, China

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