Periapical periodontitis

Researchers test whether a rinse made from frankincense (Boswellia sacra) removes bacteria from infected root canals as well as the standard sodium hypochlorite rinse. Thirty adults aged 18 to 50 with a dead or infected tooth take part. Each person is randomly assigned to one of …

This study tests whether a procedure called full pulpotomy can successfully treat permanent teeth with irreversible pulpitis and apical periodontitis. Instead of removing the entire nerve like a root canal, full pulpotomy removes only the inflamed pulp from the crown, preserving …

This trial asks whether a minimally invasive root canal procedure can match the success of the traditional approach in treating lower molars with dead nerves and an infected root tip. Sixty adults aged 20 to 50 with such molars will be randomly assigned to receive either a conser…

This trial tests whether adding silver nanoparticles to a standard antibiotic paste used inside root canals can better reduce pain and inflammation in people with symptomatic apical periodontitis, a painful infection at the tooth root. Half of the 50 adult participants receive th…

This study tests whether using platelet-rich fibrin (PRF) – a concentrate made from a patient's own blood – can reduce pain and improve healing after endodontic microsurgery (root-end surgery). Twenty adults with failed root canals and persistent infection in front teeth or premo…

This study tests whether amla (Emblica officinalis), a medicinal plant, can replace standard sodium hypochlorite as a disinfectant during root canal treatment. The trial includes 66 people aged 18–50 with infected single-rooted front teeth. Researchers measure how well each solut…

This study tests whether a new cleaning technology (GentleWave) is better than standard methods for disinfecting root canals in molars that still have infection after initial treatment. About 60 adults with persistent infection will be randomly assigned to receive either the new …

This study compares two materials used to fill root canals during retreatment of infected teeth: standard gutta-percha and a newer material called MTA. About 58 adults with small infections around the tooth root will be treated and followed for one year. Researchers will check he…

This study compares two medicines placed inside a tooth after root canal treatment to see which one helps heal infections around the tooth root faster. About 62 adults with infected single-rooted teeth will receive either triple antibiotic paste or calcium hydroxide. The research…

This study looks at whether adding other medicines to a standard root canal disinfectant (calcium hydroxide) can kill more bacteria in infected teeth. The trial will involve 45 adults with a tooth infection called apical periodontitis who need a repeat root canal. Researchers wil…

This study tests if garlic gel can replace the usual medicine placed inside teeth during root canals. About 96 people with infected permanent teeth will get either garlic gel or calcium hydroxide. Researchers will check pain, swelling, and X-ray healing to see if garlic works as …

This study tests whether a gel made from a patient's own blood (platelet-rich fibrin) can help regenerate the inner part of infected or dead teeth in adults. 57 participants will receive either the gel or a standard blood-clot treatment. The goal is to see if the gel reduces infe…

This study tests whether a less invasive dental procedure called full pulpotomy can heal infected molars as well as root canals. Researchers will treat 128 adults with deep cavities and compare healing in teeth with and without infection at the root tip. If successful, it may off…

This trial looks at whether changing how the dentist's tool moves during a root canal can reduce pain afterward. Adults with an infected lower premolar will get standard root canal treatment, but the file system will use either a continuous spin or a back-and-forth motion, with d…

This study tests whether a newer bioceramic filling material reduces pain after root canal treatment better than the standard calcium hydroxide filling. Twenty-eight adults with painful lower molar infections will receive one of the two fillings during their root canal. Pain leve…

This study compares two ways of using an anti-inflammatory drug (ketorolac) during root canal treatment: one at room temperature and one chilled. The goal is to see if the cold version reduces pain better after the procedure. Sixty adults with tooth infections will be enrolled, a…

This study compares two single-dose pain relievers—piroxicam and prednisolone—given before a root canal to see which one reduces pain better afterward. Sixty adults with an inflamed tooth nerve and infection will take one of the drugs right before treatment. The goal is to find a…

This study will test if a technique called 'apical patency'—gently passing a small file just past the root tip during cleaning—can reduce pain after a root canal. 48 adults with a dead nerve and infection in a back molar will be randomly assigned to receive either this technique …

This study looks at three different ways to clean infected root canals in 66 men aged 18-35. The goal is to see which method best reduces signs of inflammation and infection. Researchers will measure certain proteins in the fluid around the tooth root before and after treatment.

This study will follow 75 adults who need root canal treatment or retreatment at a hospital dental clinic in Rome. Researchers will check how well the teeth heal using X-rays and symptom reports over up to 5 years. The goal is to understand success rates and how factors like over…

This study looks at how well root canal treatments work when done in general dental clinics, rather than specialist offices. Researchers will check about 1500 patients who had root canals in 2023 to see if infections remain after treatment. The goal is to understand why results m…