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Which pill eases root canal pain best? new study tests two options

NCT ID NCT07281807

Symptom relief Sponsor: RANA AHMAD Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study compares two single-dose pain relievers—piroxicam and prednisolone—given before a root canal to see which one reduces pain better afterward. Sixty adults with an inflamed tooth nerve and infection will take one of the drugs right before treatment. The goal is to find a simple way to make root canals less painful.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
piroxicam and prednisolone
What this could lead to
If one drug works better, dentists may have a simple, single-dose option to reduce pain after root canal treatment.
What could go wrong
This is a small, early-phase trial with only 60 participants, so results may not apply to everyone. Pain relief varies, and neither drug is a cure.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

About 60 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Jan 2026

An estimate. Start dates often move.

Expected to finish

Jan 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 40 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Healthy patient ranging between 18-40 years * Having at least one premolar with diagnosis of symptomatic irreversible pulpitis according to history, examination and radiographs. * Teeth having mature apex confirmed by periapical radiographs. Exclusion Criteria: * History of systemic disorders including HIV, Hepatitis * Pregnancy (As per Medical record/ Verbally) * Patient using medication such as analgesics or anti-inflammatory drugs * Patient allergic to lignocaine, piroxicam and prednisolone * Tooth not suitable for restoration * Periodontal probing depth ≥ 4mm * Retreatment cases * Patients having calcified canals assessed by radiographic findings

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Conditions

The condition(s) this trial relates to.

acute apical periodontitis periapical periodontitis pulpitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Irreversible pulpitis with apical periodontitis Symptomatic apical periodontitis

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  2. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

More trials for these conditions

Other studies related to the condition(s) this trial covers.