Obesity due to pro-opiomelanocortin deficiency

This early-phase trial tested a new drug called HDM1005 in 40 overweight or obese adults. Participants received either the drug or a placebo as a shot under the skin. The main goal was to check safety and how the body processes the drug, not yet to prove it works for weight loss.

This study tests whether empagliflozin, a drug used for type 2 diabetes, can improve blood sugar control in 60 overweight or obese adults with prediabetes. Participants take the drug or a placebo for 13 weeks. The goal is to see if the drug helps the body use sugar better and low…

This trial tests whether leucine, an amino acid, can help older men preserve muscle mass while losing weight through alternate-day fasting. Overweight or obese men of Asian descent will receive either leucine, protein, or a placebo supplement for four weeks. The study measures ch…

This study tested whether taking extra leucine, a natural amino acid, helps preserve muscle during a 4-week alternate-day fasting program in overweight young men. Participants were randomly assigned to one of four doses of leucine. Researchers measured body composition, blood mar…

This trial is testing whether a compound called sodium pentaborate pentahydrate can help people with overweight or obesity lose weight and improve their blood sugar. Participants will receive either the compound or a placebo, and researchers will track changes in body weight, wai…

This study looks at whether giving tranexamic acid during weight-loss (bariatric) surgery can reduce bleeding. Researchers will compare patients who received the drug with those who did not, focusing on drops in hemoglobin levels, need for transfusions, hospital stay length, and …

This phase 3 trial is testing a drug called setmelanotide in people with obesity linked to certain gene variants (POMC, PCSK1, LEPR, NCOA1, or SH2B1). About 296 participants, aged 6 to 65, will receive either the drug or a placebo to see if it helps reduce body weight. The study …

This study tested a 100-day weight management program in 140 overweight adults. The program included meal replacements, protein and fiber supplements, probiotics, diet plans, exercise, and counseling. Researchers measured weight loss and health changes to see if the program is sa…

This early study tested a new medicine, NNC0519-0130, in 161 people to see if it is safe and how it works in the body. The medicine aims to lower blood sugar and reduce appetite, which could help people with type 2 diabetes and overweight. Participants received either the medicin…

This study tested whether giving tranexamic acid (TXA) during weight-loss surgery reduces bleeding. 132 adults having sleeve gastrectomy received either TXA or a placebo right after anesthesia. The results showed that TXA lowered blood loss during and after surgery, without incre…

This trial tests whether injecting a local anesthetic called ropivacaine into the abdominal wall during gastric bypass surgery can reduce the need for opioid painkillers in the first 24 hours after the operation. Half of the 148 participants receive the nerve block, while the oth…

This trial tests whether a smartphone app can help people with obesity take a more active role in their care around bariatric (weight-loss) surgery. The app helps users track diet and exercise, report problems, and organize medical documents, with a nurse available to connect the…

This trial tests whether combining two nerve-block techniques—one targeting the stomach area and another the abdominal wall—can better control visceral pain after laparoscopic bariatric surgery. Visceral pain is a deep, internal discomfort that often causes nausea and doesn't res…

This trial investigates whether a 20-minute virtual reality nature scene or the Benson Relaxation Technique can lower anxiety and increase happiness in adults who have recently had bariatric surgery. Participants are randomly assigned to one of two groups or a control group, and …

This study compared two ways to find the right spot for spinal anesthesia in 100 obese women having C-sections. One group used ultrasound to guide the needle, the other used traditional touch-based landmarks. The goal was to see which method leads to a successful first attempt, r…

This study looks at whether giving a nerve block (TAP block) early during laparoscopic sleeve gastrectomy reduces pain more than giving it later. About 200 adults having this weight-loss surgery will receive the same numbing medicine, but at different times. Researchers will comp…

This study compares two types of stitches used during robotic gastric bypass surgery for weight loss. About 150 adults with severe obesity will be randomly assigned to receive either a special barbed suture or a standard one. The main goal is to see which stitch is faster to use …

This study tested whether a short educational video watched before bariatric surgery could lower patients' fear and improve their recovery. Fifty-one adults having weight-loss surgery were randomly assigned to either watch the video or receive standard care. Researchers measured …

This study tested whether adults who have bariatric sleeve gastrectomy (a type of weight-loss surgery) can safely recover at home instead of in the hospital. Twenty-eight participants received acute care at home, including nurse and doctor visits, lab tests, and 24/7 urgent suppo…

This study tested whether using virtual reality glasses for discharge education helps patients better care for themselves after bariatric surgery. Sixty adults who had laparoscopic weight-loss surgery were split into two groups: one received standard care, the other watched a 15-…

This completed trial tested whether a nerve block called erector spinae plane block (ESPB) can reduce pain and opioid use in super obese patients (BMI over 50) after laparoscopic bariatric surgery. Sixty participants received either the ESPB or standard local anesthetic at the in…

This study follows 160 people for 12 months after laparoscopic sleeve gastrectomy to measure changes in two hormones made by fat tissue: asprosin and neuregulin 4. Asprosin rises with obesity and insulin resistance, while neuregulin 4 falls, and researchers want to see if their s…

This study looks at how a protein called FABP4, which is linked to fat metabolism, changes in the blood after Roux-en-Y gastric bypass surgery. Researchers are following 28 adults who had the surgery, measuring FABP4 levels along with weight, body composition, inflammation, and g…

This study looks at how two different ways of managing pain after laparoscopic sleeve gastrectomy affect lung function. One method uses an epidural catheter to deliver numbing medicine near the spine, while the other uses pain medicine given through an IV. Researchers measure bre…

This study looked back at the records of over 9,000 people who had weight-loss (bariatric) surgery. The goal was to find factors that might predict bleeding during or within 30 days after surgery. By identifying these risk factors, doctors hope to create a score that can help pre…

This study looked at how stress influences eating and physical activity in African-American, Hispanic, and white teen girls aged 13-17. Researchers measured food intake after stress and non-stress sessions, along with BMI and activity levels. The goal was to understand why obesit…

This study tested a special stitch device (STRATAFIX Spiral PDS Plus) used in robot-assisted surgeries for weight loss (sleeve gastrectomy) and hysterectomy. 161 adults took part. The main goal was to see how well it controlled bleeding after stitching. Doctors also rated how eas…

This study looked at how safe and effective the easyEndo™ powered stapler is when used in weight-loss surgery. Researchers checked if the stapler worked correctly during and after surgery in 60 patients. The goal was to see if the device is reliable for cutting and sealing tissue…

This study looked at how a new drug called GZR18 is processed in the bodies of 6 overweight or obese men. The drug was given as a single injection, and researchers measured how much of it came out in urine and stool over 78 days. The goal was to understand how the drug is broken …

This completed study observed 563 patients who had weight-loss (bariatric) surgery and received extra oxygen during their first night in the hospital. Researchers tracked how often oxygen levels fell below 90% and what actions nurses took, like adjusting the oxygen flow or reposi…

This study followed 1100 adults with severe obesity who took WEGOVY (semaglutide) for 12 months. Researchers collected data on weight, eating habits, and blood markers to see how the drug worked in different groups. The goal is to use this information, along with artificial intel…