Can a Boron-Based pill tame obesity and blood sugar?
NCT ID NCT05741606
First seen Aug 11, 2026 · Last updated Aug 12, 2026 · Updated 1 time
Summary
This trial is testing whether a compound called sodium pentaborate pentahydrate can help people with overweight or obesity lose weight and improve their blood sugar. Participants will receive either the compound or a placebo, and researchers will track changes in body weight, waist size, and other health measures. The study aims to see if this approach is safe and effective.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- sodium pentaborate pentahydrate
- What this could lead to
- If it works, this could point toward a new medication to help people with overweight or obesity lose weight and improve blood sugar control.
- What could go wrong
- This is an early-stage trial, so the safety and effectiveness are not yet proven. The results may not lead to a widely available treatment, and there could be side effects.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Phase 1/2
Runs two stages together: safety and dose first, then whether the treatment works.
- Participants
-
177 people
The number who actually took part.
- Started
-
Jul 2024
- Finished
-
Jan 2025
- Lead sponsor
-
Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
-
18 years and older
- Sex
-
Anyone
- Healthy volunteers
-
Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Age ≥18 years at the time of signing the informed consent. * A non-pregnant female participant or a male participant who has been surgically sterilized (vasectomy) or is willing to use appropriate contraceptive methods during the trial (until the end of the trial). * Body mass index (BMI) ≥30·0 kg/m2 or BMI ≥27·0 kg/m2 in the presence of hypertension or dyslipidemia (treated or untreated, assessed at the discretion of the investigator). Exclusion Criteria: * Glycosylated hemoglobin (HbA1c) ≥48 mmol/mol (6.5%) as measured by the laboratory at screening. * History of type 1 or type 2 diabetes. * Treatment with glucose-lowering drug(s) within 90 days prior to screening. * Obesity caused by endocrine disorders (such as Cushing's syndrome) * Change in body weight of more than 5 kg during the 90 days before screening regardless of medical records. * Treatment with any drug proven to control weight in the 90 days before screening. * Previous or planned obesity treatment (during the trial period) with surgery or a weight loss device. However, the following are permitted: (1) liposuction and/or abdominoplasty, if performed more than one year prior to screening; (2) lap banding, if the banding was removed more than 1 year before the screening. (3) intragastric balloon, if the balloon was removed more than 1 year before the screening. or (4) duodenal-jejunal bypass sleeve, if the sleeve was removed more than 1 year before the screening. * Uncontrolled thyroid disease, defined as TSH \>4·78 mIU/L or 1.5 times the upper limit of normal as measured by a laboratory at screening. * Inadequately treated hypertension, defined at screening as systolic ≥180 mmHg or diastolic ≥110 mmHg. * History of malignant neoplasms in the last 5 years before the screening. Basal and squamous cell skin cancer and any in situ cancer are allowed. * Presence or history of cardiovascular disease, including stable and unstable angina pectoris, myocardial infarction, transient ischemic attack, stroke, cardiac decompensation, clinically significant arrhythmias, or clinically significant conduction disturbances. * The participant is currently classified as having New York Heart Association Class IV heart failure. * Surgery planned during the trial period, excluding minor surgery, at the discretion of the investigator. * Known or suspected abuse of alcohol or recreational drugs. * Known or suspected hypersensitivity to test product(s) or related products. * Participation in another clinical trial within 90 days prior to screening. * Personal or first-degree relative history of multiple endocrine neoplasia type 2 or medullary thyroid carcinoma. * Presence of acute pancreatitis within 180 days before screening. * History or presence of chronic pancreatitis. * Any impairment, unwillingness, or disability, not covered by any of the other exclusion criteria, that in the opinion of the investigator may compromise the participant's safety or compliance with the protocol.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Imam Reza hospital and Clinic of Salamat
Tabriz, East Azarbayejan, 5166614766, Iran
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