Obesity due to congenital leptin deficiency

This trial compares two surgical techniques used during one-anastomosis gastric bypass for severe obesity. One method sets the length of the bypassed intestine based on the patient's measured total small bowel length, while the other uses standard lengths based on body mass index…

This study compares two approaches for adults with severe obesity: an intensive non-surgical program (meal replacements, behavior support, and weight-loss medication) versus bariatric surgery. Researchers will track 500 participants to see which method better improves health and …

This study tests whether taking daily protein supplements and doing resistance exercises (like lifting weights) can prevent too much muscle loss after bariatric surgery. About 400 patients will be randomly assigned to either standard care or standard care plus the protein and exe…

This study tests whether adding hands-on cooking classes to a standard weight loss program helps young adults (18-35) with mild-to-moderate intellectual disabilities lose more weight and keep it off. Over 24 months, 114 participants will either follow a healthy eating plan with c…

This study tests an experimental drug called mibavademab in people with a rare form of obesity caused by a faulty leptin gene. The drug aims to help control hunger and body weight. Only 4 participants will be enrolled to see how well it works and if it is safe.

This study looks at how the size of the tube (bougie) used during laparoscopic sleeve gastrectomy affects outcomes like weight loss and complications. About 100 adults with obesity will be randomly assigned to receive a small (36-Fr) or extra-large (over 40-Fr) bougie. The goal i…

This study tests a weekly injection called RM-718 in healthy people with obesity and in patients with obesity caused by problems in the MC4R pathway, including hypothalamic obesity and Prader-Willi syndrome. The main goal is to check the drug's safety and how the body processes i…

This study tests tirzepatide, a weight loss medication, in 36 young adults aged 18-26 with obesity from Prader-Willi syndrome, hypothalamic obesity, or general causes. Participants take the drug for 48 weeks to see how much weight they lose and how their health changes. The goal …

This study tests whether a daily powder containing fiber and plant compounds (inulin, resveratrol, quercetin) can reduce brain inflammation in 120 overweight women aged 35-60 who are going through menopause. Participants take the supplement or a placebo for 6 months, and research…

This Phase 3 study tests a once-weekly injection called eloralintide in 900 adults with osteoarthritis of the knee who are also overweight or obese. The goal is to see if it reduces knee pain and helps with weight loss compared to a placebo. Participants will be in the study for …

This study tests whether a wrist-worn device called Reletex Reliefband can reduce nausea and vomiting after bariatric sleeve gastrectomy. The device uses mild electrical pulses to stimulate nerves and suppress nausea. Researchers will compare it to a sham device in 100 adults to …

This study tests if a mild electrical patch placed on the skin (called TENS) can prevent breathing problems after weight-loss surgery in people with severe obesity. About 70 participants will be randomly assigned to receive either TENS or a fake device. The main goal is to see if…

This study tests whether a synbiotic supplement (a mix of probiotics and prebiotics) can improve gut health and reduce mild stomach discomfort in adults aged 50-70 who are overweight. Participants take the supplement or a placebo daily for 8 weeks, and researchers measure changes…

This study looks at whether a special diet workshop held 15 days after bariatric surgery can help patients increase their protein intake. About 88 adults who are scheduled for weight-loss surgery will take part. The goal is to improve protein levels and overall recovery over the …

This study looks at how the hormone insulin controls blood sugar and fat in healthy adults and those at risk for type 2 diabetes. Researchers will give participants a single dose of a drug called alpelisib, which blocks some of insulin's effects, to see if the liver can still mak…

This study investigates why people with overweight or obesity often have a reduced muscle-building response to resistance exercise and protein intake compared to lean individuals. Researchers will compare muscle tissue samples from lean and overweight/obese participants before an…

This study is investigating how immune cells called macrophages in fat tissue handle fat and influence metabolism. Researchers will compare people with obesity and related metabolic issues to lean individuals, using imaging, blood tests, and tissue biopsies. The goal is to unders…

This study investigates how immune cells in fat tissue, called macrophages, handle fats and whether this affects metabolism in people with obesity. Researchers will compare adults with obesity and type 2 diabetes or fatty liver to lean individuals, using imaging, blood tests, and…

This study looks at how two common weight-loss surgeries — gastric bypass and sleeve gastrectomy — change the way the body processes the antidepressant fluoxetine (Prozac). Researchers will measure drug levels in the blood of 12 participants before and after surgery. The goal is …

This study investigates how two common weight-loss surgeries—gastric bypass and sleeve gastrectomy—change the way the body absorbs the blood thinner apixaban. Researchers will measure apixaban levels in the blood of 12 participants before and after surgery. The goal is to underst…

This study looks at how different snacks (walnuts or pretzels) change brain activity related to food cravings and fullness during a 12-week weight-loss diet. Researchers will use brain scans to measure responses to food pictures and track changes in body fat and appetite. The goa…

This study is tracking 2000 adults who are having weight-loss (bariatric) surgery to learn what factors influence their pain and daily functioning afterward. Researchers will use patient questionnaires to measure pain, side effects, and long-term recovery. The goal is to better u…

This study creates a global database to collect information from people with genetic obesity. Researchers aim to learn how the condition progresses, what complications arise, and how different genetic types respond to standard treatments. Up to 5,000 participants will share data …