Normal pressure hydrocephalus

This study tests whether a brain shunt—a device that drains extra fluid—can improve walking and thinking in older adults with idiopathic normal pressure hydrocephalus (iNPH). One hundred participants will either receive an active shunt or a placebo procedure. The main goal is to …

This trial is testing a device called Neuclare, which stimulates the brain, to see if it can improve walking and thinking in people with idiopathic normal pressure hydrocephalus (iNPH), a condition that causes gait problems, memory issues, and sometimes incontinence. The study wi…

This study tested whether the drug acetazolamide can improve walking in people with normal pressure hydrocephalus (NPH), a condition where excess fluid in the brain causes trouble walking, thinking, and bladder control. Fifty adults with NPH were randomly assigned to receive eith…

This study follows people with idiopathic normal pressure hydrocephalus (iNPH) who are already scheduled for shunt surgery. Researchers measure changes in thinking skills and frailty one year after the procedure to identify which patients are most likely to improve. The goal is t…

This lab study uses leftover spinal fluid from 10 patients with normal pressure hydrocephalus to see if common numbing medicines form crystals. Researchers mix different drugs and watch for crystals over 60 minutes. The goal is to understand risks, not to treat patients directly.

This study explores whether a special type of MRI called flow MRI can improve the diagnosis and management of normal pressure hydrocephalus, a condition where excess fluid builds up in the brain's cavities. Researchers will measure how cerebrospinal fluid and blood move through t…

This study looked at 75 older adults with suspected normal pressure hydrocephalus, a condition that can cause a reversible form of dementia. Researchers used a combination of fluid infusion tests and special MRI scans to better understand how brain fluid and pressure interact. Th…

This study looked at 70 people with idiopathic normal pressure hydrocephalus (iNPH), a condition that causes walking problems, memory loss, and bladder control issues. The goal was to find better ways to predict which patients would benefit from a surgery that drains extra fluid …

This completed observational study looked at 29 people with suspected normal pressure hydrocephalus (NPH), a condition where fluid builds up in the brain. Researchers used a special MRI technique called DTI-ALPS to measure the function of the brain's waste-clearing 'glymphatic sy…

This study looked at proteins in the spinal fluid of 100 people with symptoms of normal pressure hydrocephalus, such as trouble walking, memory loss, and bladder control issues. Researchers used a new method to analyze the fluid and compared results with walking tests and brain s…

This study tested whether a special MRI scan (flow MRI) can predict how well patients with normal pressure hydrocephalus will respond to surgery. Currently, doctors use a lumbar puncture (spinal tap) to make this prediction. The study enrolled 30 adults and measured cerebrospinal…