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New study aims to take the guesswork out of brain surgery for walking problems

NCT ID NCT02495610

Knowledge-focused Sponsor: University of Zurich Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at 70 people with idiopathic normal pressure hydrocephalus (iNPH), a condition that causes walking problems, memory loss, and bladder control issues. The goal was to find better ways to predict which patients would benefit from a surgery that drains extra fluid from the brain. Researchers tested walking, thinking, and bladder function before and after a spinal tap to see if those tests could accurately forecast surgery outcomes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 70 people

The number the study aims to enrol. It can still change while the study runs.

Start date

Jun 2015

Finished

Dec 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

50 to 85 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Informed consent. * Age 50 years or above * Impaired walking function for at least 3 months, onset at/ after 40 years of age. * MRI or CT with enlarged ventricular system (Evans' index ≥0.30) without evidence of moderate or severe cortical atrophy. * Eligible for shunt surgery. * Eligible for analysis of gait, neuropsychological and urological function. * Subjects must be able to understand the patient information sheet and comply with the requirements of the protocol. Exclusion Criteria: * Previous intracranial disorder or surgery. * Contraindications to surgery or MRI * Contraindications to the testing of gait, bladder or neuropsychological function. * Presence of concomitant disease which might reasonably account for the clinical symptoms or radiological findings. * Worsening of walking function secondary to any other condition occurring during the study.

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Conditions

The condition(s) this trial relates to.

normal pressure hydrocephalus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Idiopathic normal pressure hydrocephalus

Contacts and locations

Locations

  • University Hospital

    Zurich, Canton of Zurich, 8091, Switzerland

More trials for these conditions

Other studies related to the condition(s) this trial covers.