Neoplastic meningitis

Researchers are testing whether combining SX-682, an experimental drug that blocks CXCR1 and CXCR2, with proton craniospinal irradiation is safe and effective for people with leptomeningeal disease from melanoma or non-small cell lung cancer. Participants take SX-682 by mouth twi…

Researchers are testing a radioactive drug called rhenium-186 obisbemeda in adults whose solid-tumor cancer has spread to the leptomeninges, the tissues lining the brain and spinal cord. The drug is a nanoliposome carrying rhenium-186, a radioactive isotope, and it is given throu…

This early-phase study tests the safety of a new cell therapy called B7-H3 CAR T cells for children and young adults whose brain tumors have come back or are growing despite standard treatment. The therapy uses the patient's own immune cells, modified to target a protein (B7-H3) …

This phase III trial tests whether proton craniospinal irradiation (pCSI) can improve survival compared to standard involved-field radiation therapy (IFRT) for patients with breast or non-small cell lung cancer that has spread to the lining of the brain and spinal cord (leptomeni…

This phase 2 trial is testing a type of radiation called craniospinal irradiation that avoids the hippocampus, a brain area key for memory. It is for people with breast or lung cancer that has spread to the fluid and lining around the brain and spinal cord. The goal is to see if …

This trial tests a new type of cell therapy for people with solid tumors that have spread to the lining of the chest, abdomen, or brain. The treatment uses a patient's own immune cells, engineered to recognize and attack cancer cells through two different targets. The goal is to …

This trial is for people with a specific type of lung cancer (EGFR-mutant non-small cell lung cancer) that has spread to the lining of the brain and spinal cord (leptomeningeal metastasis) and has stopped responding to third-generation targeted pills. The study tests whether a pe…

This trial is testing whether combining two drugs—amivantamab given intravenously and pemetrexed injected directly into the spinal fluid—can safely help people with a specific type of lung cancer that has spread to the membranes around the brain and spinal cord. This condition, c…

This phase II trial tests whether injecting two chemotherapy drugs—thiotepa and methotrexate—directly into the spinal fluid can shrink or control breast cancer that has spread to the leptomeninges (the lining of the brain and spinal cord). Participants receive the drugs through a…

This early-phase trial tests whether deferoxamine, a drug given directly into the spinal fluid, is safe for people with leptomeningeal metastases—cancer that has spread to the lining of the brain and spinal cord. Researchers will test different doses in 35 adults with solid tumor…

This study tests a dendritic cell vaccine given directly into the spinal fluid for people with breast cancer that has spread to the lining of the brain and spinal cord (leptomeningeal disease). The vaccine is combined with either trastuzumab (for HER2-positive cancer) or nivoluma…

This study tests a high dose of the chemotherapy drug methotrexate given through a vein in people with breast cancer that has spread to the lining of the brain. The goal is to see if it helps them live longer. The trial includes adults with triple-negative, HER2-positive, or horm…

This study tests whether injecting a PD-1 inhibitor (tislelizumab or pembrolizumab) plus pemetrexed directly into the spinal fluid can help people with non-small cell lung cancer that has spread to the lining of the brain (leptomeningeal metastases). The trial will enroll 17 adul…

This early-phase study is testing whether a combination of low-dose radiation to the whole brain, an immunotherapy drug (PD-1 inhibitor), and chemotherapy given directly into the spinal fluid can safely treat lung cancer that has spread to the lining of the brain and spinal cord.…

This early-phase trial tests whether injecting methotrexate-loaded vesicles (tiny drug-carrying particles made from patients' own tumor cells) into the spinal fluid can safely treat lung cancer that has spread to the brain lining. About 14 adults who have failed standard treatmen…

This study tests a higher dose of a targeted therapy (EGFR-TKI) combined with two other drugs for people with advanced lung cancer that has spread to the lining of the brain and worsened on standard treatment. About 30 participants will receive the triple combination to see if it…

This study tests a new drug called NBQ72S in 10 people with breast cancer that has spread to the lining of the brain or spinal cord (leptomeningeal metastases). Participants receive the drug every 28 days. The goal is to see if the drug can control the cancer and improve survival…

This phase 2 trial tests whether adding a chemotherapy drug (thiotepa) directly into the spinal fluid can prevent glioblastoma from spreading to the brain and spinal cord lining. The study enrolls 38 newly diagnosed patients whose tumors touch brain fluid spaces or whose surgery …

This trial is testing a higher, every-other-day dose of the drug furmonertinib in people with a specific type of lung cancer (EGFR-mutant NSCLC) that has spread to the lining of the brain and spinal cord (leptomeningeal metastasis). The study will compare this high-dose schedule …

This phase 2 trial tests a combination of pemetrexed (given into the spinal fluid) and a tyrosine kinase inhibitor for people with a specific type of lung cancer (EGFR-mutant NSCLC) that has spread to the lining of the brain and spinal cord (leptomeningeal metastasis) after the d…

This early study tests whether injecting two cancer drugs (pemetrexed and bevacizumab) directly into the spinal fluid is safe for people with a specific type of lung cancer that has spread to the lining of the brain. The trial will enroll 19 adults whose cancer has worsened despi…

This study is for people with HER2+ breast cancer that has spread to the lining of the brain and spinal cord (leptomeningeal disease). It combines targeted drugs (tucatinib, trastuzumab, capecitabine) with radiation to the brain or spine. The goal is to see if this approach helps…

This study is testing a drug called zorifertinib as the first treatment for people with advanced non-small cell lung cancer that has a specific gene mutation (EGFR) and has spread to the brain or spinal cord. The trial will enroll 800 participants and compare zorifertinib to othe…

This study tests a chemotherapy drug called pemetrexed, given directly into the spinal fluid, for people with a specific type of lung cancer that has spread to the lining of the brain and spinal cord. The cancer must have gotten worse even after taking a high dose of a targeted t…

This Phase II trial tests whether a precise type of radiation called photon VMAT craniospinal irradiation can help people with breast or lung cancer that has spread to the fluid and lining around the brain and spinal cord. About 35 adults with this condition will receive radiatio…

This study tests whether giving two drugs directly into the spinal fluid can shrink or control breast cancer that has spread to the lining of the brain. It is for people with HER2-positive breast cancer. The drugs are given through a small device placed under the scalp. The goal …

This study tests a new treatment called BioTTT001, a modified virus designed to attack cancer cells, in 42 adults with recurrent non-small cell lung cancer that has spread to the lining of the brain. The treatment is given through a small device placed in the head. The main goals…

This study is for people with HER2-negative breast cancer that has spread to the lining of the brain (leptomeningeal metastasis). It compares standard chemotherapy given through the veins or by mouth to the same treatment plus extra chemotherapy delivered directly into the spinal…

This study tests a combination of two oral chemotherapy drugs (tucatinib and capecitabine) plus a targeted antibody given directly into the spinal fluid (trastuzumab) for people with HER2-positive breast cancer that has spread to the lining of the brain and spinal cord (leptomeni…

This study tests a combination of two drugs—sacituzumab govitecan (given through a vein) and pemetrexed (given into the spinal fluid)—for people with HER2-negative breast cancer that has spread to the lining of the brain and spinal cord (leptomeningeal metastases). This condition…

This study tests whether adding a chemotherapy drug (pemetrexed) directly into the spinal fluid, alongside a targeted pill (like osimertinib), works better than the pill alone for people with a specific type of lung cancer that has spread to the brain lining. About 100 adults wit…

This study is testing whether a new contrast agent called gadopiclenol (VUEWAY) can improve MRI scans to detect leptomeningeal disease (LMD), a condition where cancer spreads to the lining of the brain and spinal cord. Researchers will compare it to the standard contrast agent ga…

This study asks brain cancer patients about their experience with telemedicine compared to in-person visits. Researchers want to learn if patients feel they receive good care through virtual appointments. The goal is to improve how care is delivered to people with brain tumors.

This pilot study is exploring whether a one-time sample of spinal fluid (taken via a lumbar puncture) can detect cancer DNA in patients with solid tumors that have spread to the brain or spinal cord. Researchers will enroll 60 participants across three groups: those with leptomen…

This study creates a registry for people with leptomeningeal disease, a rare condition where cancer spreads to the lining of the brain and spinal cord. Researchers will collect information on how the disease progresses, what treatments are used, and any side effects. The goal is …

This early study tests if a portable device that creates electric fields is safe and practical for people with breast or lung cancer that has spread to the lining of the spine. Only 5 participants will wear the device for at least 28 days. The goal is to see if the treatment is t…

This study looks at the fluid around the brain (cerebrospinal fluid) in people with breast cancer that has spread to the brain or its lining. Researchers collect this fluid to study the cancer's genetic material without needing surgery. The goal is to better understand why breast…

This study looks at how much of the drug T-DXd enters brain tumors in people with HER2-positive brain cancers or glioblastoma. Thirty participants will receive T-DXd before surgery to remove a brain tumor, and researchers will measure drug levels in the tumor. The goal is to see …

This study is for people with solid tumors that have spread to the brain. Researchers want to collect medical information and samples (like blood and spinal fluid) to better understand why and how brain metastases happen. The goal is to find new ways to treat or prevent them in t…

This study enrolls 30 adults with breast cancer that has spread to the lining of the brain or spinal cord (leptomeningeal disease). Researchers will collect tissue and fluid samples to learn more about this aggressive condition. The goal is to provide faster test results and trea…