Myocardial disorder

This study tested an experimental drug called BI 765845 in 160 adults who had just had a heart attack. Participants received either the drug or a placebo, and doctors measured heart damage using MRI scans over 3 months. The trial was terminated early, so it is unclear if the drug…

This early-phase trial tests whether a single dose of donor stem cells (OmniMSC-AMI) given directly into the heart arteries is safe for people who have just had a major heart attack. The study enrolls adults aged 20–80 with a specific type of heart attack (anterior STEMI) who are…

This study tested an intravenous antiplatelet drug called PRT060128 in 70 people having a severe heart attack (STEMI). The goal was to see if giving the drug before emergency artery-opening treatment improved blood flow and was safe. The trial was terminated early, so the full re…

This study tested whether the anti-inflammatory drug colchicine could prevent nerve damage in the heart after a heart attack. About 54 adults who had a first heart attack and underwent artery-opening treatment were given colchicine or a placebo for one month. The trial was termin…

This study looked at two ways to manage older patients (80+) who had a mild type of heart attack (NSTEMI). One group got routine angiography (an invasive look at the heart's arteries), while the other group first had a non-invasive imaging test (SPECT or stress echo) and only got…

This study tested whether giving extra oxygen directly to the heart for 60 minutes after angioplasty could improve outcomes for people having a major heart attack. Only 17 patients were enrolled before the study was stopped early. The goal was to see if this oxygen therapy could …

This trial tested a new drug called MT1002 in 6 people having a heart procedure (PCI) after a heart attack. The goal was to see if it could safely control blood clotting. However, the study was stopped early, so we don't have enough information to know if the drug works or is saf…

This study looked at whether giving a powerful cholesterol-lowering drug (evolocumab) very early after a major heart attack could help the heart pump better and prevent long-term damage. About 119 adults who were having a heart attack and scheduled for a procedure to open blocked…

This study looked at whether using two types of 'ischemic conditioning' (brief cycles of blood flow restriction and release) could improve outcomes for people having a major heart attack. One method used a blood pressure cuff on the arm, the other used a balloon inside the heart …

This study tested whether personalizing blood-thinning drugs based on a patient's genetics and risk factors could reduce bleeding after a heart attack. It enrolled 39 patients who had already been on standard dual therapy for a year. The trial was terminated early, so the finding…

This study tested whether a single dose of the drug abciximab given directly into the heart artery works as well as the standard approach of a dose into a vein followed by a 12-hour infusion. The goal was to reduce heart muscle damage in people having their first non-ST elevation…

This phase 2 trial tested whether using ultrasound and microbubbles (sonothrombolysis) alongside standard clot-busting drugs could help restore blood flow in people having a severe heart attack. The study planned to enroll 41 participants but was terminated early. The main goal w…

This pilot study tested whether a special PET scan (FDG-PET/CT) can detect hidden heart inflammation in cancer patients receiving immune checkpoint inhibitors (ICIs). The goal was to catch this inflammation early, before it becomes severe. Only 2 participants were enrolled, and t…

This study tested whether a special CT scan can accurately assess heart muscle damage in people who had a heart attack more than 24 hours earlier. The goal was to see if this CT could replace the need for both an MRI and an invasive angiogram. The study enrolled 31 adults and com…

This completed study looked at whether stomach emptying is slower during a heart attack, which could delay the absorption of crucial antiplatelet drugs. Researchers measured paracetamol levels in the blood every 15 minutes in 23 participants to track stomach emptying. The goal wa…

This study looked at why some people who have a heart attack develop extra fluid around the heart (pericardial effusion). Researchers planned to use MRI scans to see if the amount of fluid was linked to other health factors and to survival one year later. Only 3 people took part …

This study looks at whether heart cells that age rapidly after a heart attack release harmful proteins that make heart disease worse. Researchers will collect blood and heart tissue samples from people undergoing coronary artery bypass surgery after a recent heart attack or for s…

This study aimed to understand why some people develop heart failure after a heart attack. Researchers used special PET scans and blood tests to measure blood vessel function and scarring in the heart muscle of 30 patients who had a first heart attack. The goal was to see if thes…

This study looked at how the heart's pumping function recovers after a short, controlled blockage of a coronary artery using a balloon. Six adults with stable coronary artery disease undergoing angioplasty had a balloon inflated in their artery for 90 seconds. Researchers measure…

This study followed 167 adults with mental health issues like anxiety, depression, or sleep problems who visited their primary care doctor. Researchers used health conversations and a blood test to track lifestyle changes and heart disease risks over up to 20 years. The goal was …

This study looked at whether an early heart MRI can help doctors know which patients with severe heart damage after a heart attack will get better on their own. The goal was to see if MRI could identify patients who would benefit from getting a defibrillator sooner rather than wa…