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Less invasive heart attack care for the elderly put to the test

NCT ID NCT03289728

Disease control Sponsor: University Hospital, Grenoble Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early This study
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looked at two ways to manage older patients (80+) who had a mild type of heart attack (NSTEMI). One group got routine angiography (an invasive look at the heart's arteries), while the other group first had a non-invasive imaging test (SPECT or stress echo) and only got angiography if the imaging showed significant blockages. The goal was to see if the imaging-guided approach was just as good at preventing death, another heart attack, or stroke over one year, while possibly reducing complications. The trial was terminated early, so the final answer is not clear.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Stress imaging (SPECT or stress echocardiogram) followed by coronary angiography only if moderate-to-severe ischemia is detected
What this could lead to
If successful, this approach could spare many elderly heart attack patients from unnecessary invasive procedures and their complications, while still catching those who need treatment.
What could go wrong
The trial was terminated early, so results are limited. The imaging-guided strategy might miss some blockages that would be found with routine angiography, potentially increasing risk of future heart events.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

588 people

The number who actually took part.

Started

Apr 2018

Finished

Jul 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

80 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients aged 80 years or older * Hospitalized for NSTEMI with or without ST-segment depression on electrocardiogram (ECG), and with raised blood concentration of troponin T or I. Raised troponin was defined as a value exceeding the 99th percentile of a normal population at the local laboratory at each participating site. A local cardiologist assessed patient eligibility and clinical condition compatible with a doubt for systematic coronary angiography due to a frailty. * Written informed consent by the patient or the next of kin in case of incapacity. Non-inclusion criteria: * Recurrent or ongoing chest pain refractory to medical treatment * Haemodynamic instability or cardiogenic shock * Life-threatening arrhythmias or cardiac arrest * Contra-indication to CA: Renal failure (creatinine clearance \<15 mL/min by Modification of the Diet in Renal Disease (MDRD)), continuing bleeding problems * Mechanical complications of MI * Severe aortic stenosis * Medical history of severe dementia (documented for more than 3 months) * Patient under administrative or judicial control * Patient who are protected under the act * No health care insurance

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Conditions

The condition(s) this trial relates to.

acute myocardial infarction coronary artery disorder myocardial infarction

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Myocardial infarction

Contacts and locations

Locations

  • Clinique Mutualiste

    Grenoble, France

  • University Hospital Grenoble

    Grenoble, France

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