One shot may replace hours of infusion for heart attack care
NCT ID NCT01080638
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested whether a single dose of the drug abciximab given directly into the heart artery works as well as the standard approach of a dose into a vein followed by a 12-hour infusion. The goal was to reduce heart muscle damage in people having their first non-ST elevation heart attack. The trial was terminated early, so results are incomplete.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- abciximab
- What this could lead to
- If it works, this could simplify treatment for certain heart attacks by using a single injection instead of a long infusion.
- What could go wrong
- The trial was terminated early, so results are limited. It only included first-time heart attack patients, so findings may not apply to others.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Phase 4
Runs after approval, following long-term safety and how well the treatment works in everyday use.
- Participants
-
150 people
The number who actually took part.
- Started
-
Aug 2009
- Finished
-
Dec 2012
- Lead sponsor
-
Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
-
18 to 80 years
- Sex
-
Anyone
- Healthy volunteers
-
Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * non-ST segment elevation acute myocardial infarction * within 48 hours presence of chest pain * Troponin-T or I positive before CAG * First myocardial infarction * will be performed coronary angioplasty Exclusion Criteria: * under 18 years of age,80 years or older * Bleeding tendency * History of major surgery within 4 weeks * Major stroke within 2 years * Thrombocytopenia (\<120,000 / uL) * Cardiogenic shock * Known allergy to aspirin, heparin, or abciximab * Contraindication of MRI at study entry (implanted pacemakers, defibrillators, intracranial metallic implants etc) * Chronic atrial fibrillation * Pregnancy
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Department of Internal Medicine, Cardiovascular Center, Seoul National University Hospital
Seoul, South Korea
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