Meningioma

This early-phase trial tests a new radioactive drug called RYZ401 in people with neuroendocrine tumors and other solid tumors that have a specific protein on their surface. The drug delivers a powerful radioactive particle directly to cancer cells. The study aims to find the safe…

This phase III trial compares radiation therapy to simple observation in patients who have had a grade II meningioma completely removed by surgery. The goal is to see if radiation helps keep the tumor from coming back. About 163 participants will be randomly assigned to either re…

This Phase 2 trial tests whether the radioactive drug Lutathera can slow or stop the growth of progressive meningioma, a type of brain tumor. About 153 adults with grade 1-3 meningioma will be randomly assigned to receive Lutathera or standard treatments like bevacizumab or evero…

This phase 2 trial tests a drug called zanzalintinib in 100 people with meningioma that has returned or worsened after standard treatments like surgery or radiation. The goal is to see if the drug can shrink tumors or slow the disease. Participants take the drug by mouth, and res…

This study tests four drugs (vismodegib, GSK2256098, capivasertib, and abemaciclib) in people with progressive meningiomas that have specific gene changes. The goal is to see if these drugs can stop tumor growth or shrink tumors. About 124 adults with confirmed mutations will rec…

This study tests several experimental drugs in people with NF2-related schwannomatosis, a genetic condition that causes non-cancerous tumors on nerves. The goal is to see if these drugs can shrink tumors and control the disease. About 109 participants will receive one of three dr…

This pilot trial is testing a type of radiation called hypofractionated stereotactic radiosurgery for people who have had surgery for a grade II or recurrent grade I meningioma. The treatment delivers higher doses of radiation in fewer sessions, which may kill leftover tumor cell…

This study is testing proton radiation as a treatment for adults with benign or slow-growing brain tumors. Researchers want to see how well it controls tumor growth and how it affects quality of life and side effects. About 100 participants will receive proton radiation and be fo…

This study tests a new drug called RYZ101 for people with meningioma that has come back or is growing despite standard treatments. RYZ101 is a radioactive substance that targets a protein found on these tumor cells, aiming to kill them while sparing healthy tissue. The trial will…

This early-stage trial tests two oral drugs, IN10018 and dalpiciclib, in 24 adults with progressive meningiomas (brain tumors that keep growing despite treatment). The main goal is to check safety and find the best dose. Researchers will also see if the combination can shrink tum…

This study tests an oral drug called JZP3507 (ONC206) in 30 adults with recurrent grade 2 or 3 meningioma, a type of brain tumor. Participants take the drug three days a week in 28-day cycles. The main goal is to see if the drug can shrink tumors, with safety and response duratio…

This study is tracking 600 people with brain tumors who receive GammaTile therapy during surgery. GammaTile is a device that delivers radiation directly to the tumor site to help prevent regrowth. Researchers are measuring how long tumors stay under control and how patients feel …

This study tests a procedure called endovascular embolization for people with meningioma, a type of brain tumor. The procedure blocks blood vessels that feed the tumor, aiming to shrink it or stop its growth. Participants are adults with growing or symptomatic meningiomas that ar…

This study is testing a drug called Lutathera in children and young adults (ages 4 to 39) whose brain tumors have come back or are growing despite treatment. The drug delivers radiation directly to tumor cells that show up on a special PET scan. The goal is to find the safest dos…

This phase IIb trial tests whether combining the drug everolimus with a targeted radiation therapy (177Lu-DOTATATE) can slow tumor growth in people with grades 2 and 3 meningioma that no longer responds to surgery or radiation. About 28 adults will receive the combination for 7 m…

This study tests a drug called 177Lu-DOTATATE for people with recurrent meningioma, a type of brain tumor that has come back after surgery or radiation. The drug delivers radiation directly to tumor cells by targeting a protein found on these tumors. About 136 adults will be rand…

This study is testing a combination of two drugs—a targeted radioactive drug (177Lu-DOTATATE) and a PARP inhibitor (olaparib)—in children and teens aged 3 to 18 with certain solid tumors that have come back or not responded to treatment. The goal is to see if the combination is s…

This study tests a new drug called [212Pb]VMT-α-NET, which delivers a powerful type of radiation (alpha particles) directly to tumor cells that have a specific marker (SSTR2). The trial includes 300 adults with advanced neuroendocrine tumors or meningioma that cannot be removed b…

This study tests the drug cabozantinib in 24 people with meningioma that has come back or worsened after standard treatments like surgery or radiation. The main goal is to see if the drug can stop the tumor from growing for at least 6 months. Participants must have a Karnofsky sc…

This phase 2 trial tests whether the drug regorafenib can slow tumor growth in people with recurrent meningioma, a type of brain tumor. About 104 participants will receive either regorafenib or standard care. The main goal is to see how long the tumor stays under control.

This study tests a new drug, ODM-212, in about 315 adults with advanced solid tumours that cannot be cured with current treatments. The trial has two parts: first finding a safe dose, then testing that dose in more people. The main goal is to check for side effects and see how th…

This study tests a new treatment using natural killer (NK) cells, a type of immune cell, for adults with aggressive brain tumors that have not responded to standard therapies. The NK cells are grown in a lab and then given through a vein and directly into the brain. The main goal…

This study tests a radioactive drug called Lutathera for people with a type of brain tumor (meningioma) that cannot be removed by surgery and has continued to grow after radiation therapy. The drug is given through a vein and targets tumor cells to stop them from growing. The tri…

This program gives eligible patients with meningioma access to the investigational drug ITM-11 before it is officially approved. The treating doctor decides if the possible benefits outweigh the risks. The program is only available in certain countries.

This study tests whether the drug abemaciclib can help people with a fast-growing type of brain tumor called grade 3 meningioma. Participants will receive either the drug or a placebo after standard radiation therapy. The goal is to see if the drug delays tumor growth. About 72 p…

This study tests a shorter course of high-dose proton radiation for people with non-cancerous brain tumors like meningiomas and schwannomas. The goal is to see if fewer treatments can still control tumor growth while reducing side effects and being more convenient. About 70 adult…

This early-stage study tests an oral drug called ONC206 in adults with brain tumors that have come back. The main goal is to find the safest dose and check for side effects. About 102 participants will take the drug once or several times a week.

This phase 3 trial compares proton beam therapy to standard photon radiotherapy in 156 adults with primary brain tumors. The goal is to see if proton therapy, which delivers less radiation to healthy brain tissue, improves functional survival—meaning living longer without tumor r…

This study is testing a new, quick MRI technique called Magnetic Resonance Fingerprinting (MRF) to better tell the difference between a brain tumor coming back and damage from radiation therapy (radiation necrosis). About 90 people will take part, including healthy volunteers, pa…

This early study tests a special MRI technique that uses a substance called hyperpolarized pyruvate to see how active a meningioma brain tumor is. About 50 adults with known or suspected meningioma will get an IV of this substance before an MRI scan. The goal is to see if this me…

This early-stage trial tests a fluorescent dye called panitumumab-IRDye800 that attaches to cancer cells. Before surgery, 30 adults with brain tumors will receive a single infusion of the dye. During their operation, a special camera will detect the dye's glow, helping surgeons d…

This study tests a new radioactive imaging agent called 68Ga-HA-DOTATATE to see if it can safely and accurately detect neuroendocrine tumors using PET/CT scans. About 600 people with known or suspected tumors will receive the agent and be followed for one year. The goal is to imp…

This pilot study tests whether a radioactive tracer called [Cu64]DOTATATE, combined with a handheld gamma probe, can help surgeons find meningioma tumors during surgery. Twenty adults with suspected or recurrent meningioma will receive the tracer before surgery, and the probe wil…

This study is testing whether a special type of MRI called magnetic resonance elastography (MRE) can measure how stiff a meningioma brain tumor is before surgery. Researchers will compare the MRE results with what surgeons find during the operation and with lab tests on the tumor…

This study is testing whether a special MRI technique called magnetic resonance elastography (MRE) can measure how stiff a spinal cord tumor is and how strongly it sticks to surrounding tissue before surgery. Knowing this could help surgeons choose the best approach and make oper…

This study tests a device called the CONVIVO system, which acts like a high-powered microscope during brain tumor surgery. It helps surgeons tell the difference between normal and abnormal tissue right away. About 30 adults with various brain tumors will take part. The goal is to…

This study tests whether a special PET/MRI scan using a radioactive tracer called Ga68-DOTATATE can better detect certain brain tumors (like meningioma) and tell them apart from changes caused by past treatments. About 200 adults with these tumors will get the scan alongside stan…

This Phase 2 trial tests a new type of radiation therapy designed to avoid key brain areas involved in memory and thinking. Sixty adults with 1 to 3 small brain metastases will receive cognitive-sparing stereotactic radiosurgery. The main goal is to see if this approach better pr…

This study tests whether slowly reducing the dose of the steroid dexamethasone after brain tumor surgery can lower side effects like high blood sugar and poor wound healing, while still preventing brain swelling. About 200 adults with certain brain tumors will be randomly assigne…

This study tests a home-based program called HOBSCOTCH-CA for brain cancer survivors who struggle with memory and thinking. The program involves weekly virtual sessions with a coach, teaching problem-solving and relaxation techniques. Researchers will compare two groups: one that…

This study tests a lab technique called pharmacoscopy that analyzes a patient's tumor tissue to find which drugs might work best for them. It includes 40 adults with various aggressive or rare brain tumors that have not responded to standard treatments. The main goal is to see if…

This study is creating a large database of medical information and blood samples from 350 adults receiving metabolic radiotherapy for thyroid, prostate, or neuroendocrine cancers. The goal is to provide researchers with valuable data to better understand these treatments. No new …

This study follows 269 people with neurofibromatosis type 2 (NF2) for up to 10 years to learn how the disease progresses. Participants will have yearly exams, MRI scans, hearing tests, and blood draws. The goal is to understand tumor growth, hearing loss, and speech or swallowing…

This study aims to find out if tumor cells can be detected in the blood or spinal fluid of patients whose aggressive meningioma has come back. Researchers will take blood and spinal fluid samples from 15 adults with recurrent grade 2 or 3 meningioma. This is a proof-of-concept st…

This study follows 300 adults with primary brain tumors (such as glioma or meningioma) who are receiving partial brain radiation. Researchers use brain scans and memory, attention, and language tests before and after treatment to understand how radiation affects thinking skills. …

This study looks at how memory, attention, and other thinking skills change in people who have surgery to remove a meningioma (a type of brain tumor) from the front or side of the brain. Researchers will test cognitive function before surgery and one year later in about 50 adults…

This study watches 200 adults having brain tumor surgery to see how often cerebrospinal fluid leaks happen and what makes them more likely. The goal is to find ways to prevent leaks and help people recover faster. No new treatment is being tested—just careful observation.

This study aims to understand why some people with meningioma, the most common type of brain tumor, have worse outcomes than others. Researchers will look at factors like race, income, education, and medical history in 3,000 adults. The goal is to identify social and health-relat…

This study compares two common methods of closing the skin after brain tumor surgery: a continuous stitch under the skin using absorbable thread versus separate stitches through the skin using non-absorbable thread. Researchers want to see which method leads to fewer wound proble…

This study looks at tiny particles in the blood (extracellular vesicles) from 60 meningioma patients who have had radiotherapy. The goal is to see if these particles can act as a 'liquid biopsy' to monitor the tumor and predict outcomes without needing a surgical biopsy. Research…

This observational study uses a special MRI technique with hyperpolarized carbon-13 pyruvate to see how brain tumors use energy. Researchers will measure metabolic byproducts in 25 adults with brain tumors before any treatment. The goal is to learn more about tumor metabolism, no…

This study is looking for 500 people with certain cancers (like eye or skin melanoma, kidney cancer, or mesothelioma) and their family members to understand how common BAP1 gene mutations are. Researchers will collect medical history and questionnaires to learn about cancer risks…

This study aims to standardize care for people with rare brain tumors by using artificial intelligence to analyze patient data and predict recovery after surgery. Researchers will collect information on symptoms, brain scans, and cognitive function from 200 adults undergoing tumo…

This early-phase study tests a special PET imaging agent that highlights immune cells (CD8+ T-cells) in brain tumors. About 20 adults with brain tumors scheduled for surgery will receive an injection of the imaging agent before their PET scan. The goal is to see if this non-invas…

This early study is testing whether a robot can help doctors perform delicate brain blood vessel procedures, such as angiography, embolization, and thrombectomy. Ten patients scheduled for these standard procedures will have them done using a robotic system instead. The main goal…

This study aims to create a large collection of blood samples from 2,500 people with or at high risk for cancer. Researchers will use these samples to study liquid biopsies, which are blood tests that may help detect cancer, track treatment response, and spot recurrence. Particip…