Glow-in-the-Dark dye could help surgeons spot brain tumors
NCT ID NCT07493447
First seen Jun 25, 2026 · Last updated Jul 01, 2026 · Updated 3 times
Summary
This early-stage trial tests a fluorescent dye called panitumumab-IRDye800 that attaches to cancer cells. Before surgery, 30 adults with brain tumors will receive a single infusion of the dye. During their operation, a special camera will detect the dye's glow, helping surgeons distinguish tumor tissue from healthy brain. The study primarily checks safety and whether the dye improves tumor visibility.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Panitumumab-IRDye800 (a fluorescent dye that attaches to cancer cells)
- What this could lead to
- If it works, this could help surgeons see brain tumors more clearly during surgery, potentially leading to safer and more complete tumor removal.
- What could go wrong
- This is a very early, small pilot study with only 30 people. The dye may not work well for all tumor types, and there is a risk of side effects from the infusion.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Early phase 1
The earliest testing in people: a first look at safety, in a very small group.
- Participants
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About 30 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Jul 2026
An estimate. Start dates often move.
- Expected to finish
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Jun 2031
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Subjects with intracranial lesions undergoing surgical removal as their standard of care will be eligible. These may include subjects status post chemotherapy and/or radiation or subjects who have undergone diagnostic biopsy for their original diagnosis and are deemed to be candidates for resection. * Subject age ≥ 18 years. * Adequate hematologic and end-organ function appropriate for surgery and panitumumab infusion as determined by routine preoperative evaluation or designee prior to infusion. If liver function, renal function, and hematologic laboratory test results are acceptable for elective surgery and panitumumab infusion, the patient is considered eligible for the study. Laboratory results will need to be obtained within 30 days prior to initiation of study treatment include: 1. Chemistry Panel - Potassium, BUN (or urea), and Creatinine 2. CBC with differential - WBC, including ANC, hemoglobin, hematocrit, and platelet count 3. Magnesium and Phosphorus * Women of childbearing potential must have a negative pregnancy test within 7 days of study drug administration. * Ability to understand and willingness to sign a written informed document or written informed consent via a surrogate consent rider from the patients' healthcare decision maker. Exclusion Criteria: * Had a myocardial infarction, cerebrovascular accident, or uncontrolled chronic heart failure within 6 months prior to enrollment. * History of infusion reactions to any monoclonal antibody therapies. * Women who are currently pregnant or breastfeeding. * Participants presenting with a baseline QTcF interval \> than 480 milliseconds. * Magnesium or phosphorus lower than normal institutional values, and subject is symptomatic. * Patients receiving Class IA (quinidine, procainamide) or Class III (dofetilide, amiodarone, sotalol) antiarrhythmic agents. * Patients with a history or evidence of interstitial pneumonitis or pulmonary fibrosis. * Patients with severe renal disease or anuria
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Vanderbilt University Medical Center
RECRUITINGNashville, Tennessee, 37232-0004, United States
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- Breathing CO2 during brain scans could reveal hidden tumor disruption