Intracranial hypertension

This trial compares two common treatments—hypertonic saline and mannitol—to see which is better at reducing dangerously high pressure inside the skull after a severe traumatic brain injury. The study includes 100 adults with severe head injuries and uses a simple ultrasound measu…

This study looks at whether a long-acting injectable HIV prevention drug (cabotegravir) can be delivered fairly and effectively in NHS sexual health clinics. Researchers will follow 200 people taking the drug for 12 months, along with 20 healthcare professionals, to see how well …

This study tests a traditional Chinese medicine mixture (red ginseng, notoginseng, and rhubarb) to help people recover from a hypertensive brain bleed without surgery. About 902 participants will receive either the herbal mix or a placebo for 28 days, alongside standard care. The…

This trial tests a new stent called SILANCE for people with idiopathic intracranial hypertension (IIH), a condition where high pressure inside the skull causes severe headaches, ringing in the ears, and vision problems. The stent is placed in a narrowed vein in the brain to impro…

This study tests whether setting a personalized 'optimal' blood pressure for each patient with severe traumatic brain injury reduces brain damage compared to standard fixed targets. Researchers will enroll 60 adults in the ICU and measure brain injury markers in the blood over fi…

Researchers are studying whether two bedside ultrasound techniques can help emergency doctors identify traumatic brain injury patients at risk of getting worse within 24 hours. The study enrolls 60 adults with acute traumatic brain injury and a low Glasgow Coma Scale score who ar…

This trial tests whether a bedside ultrasound of the eye can reliably detect raised pressure inside the skull, a condition that can damage the brain if not treated quickly. Researchers will measure the optic nerve sheath diameter in adults suspected of having high brain pressure …

This trial tests whether two non-invasive tools can help paramedics detect dangerously high pressure inside the skull in patients with sudden brain injury, such as stroke or head trauma, before they reach the hospital. The tools are a wearable sensor placed on the head and an ult…

This study looks at how to make HIV prevention pills (PrEP) easier for young people to get and keep using. Researchers will follow 1000 current or eligible PrEP users in Alabama and Botswana for 2 years. They will also create and test a decision-support toolkit to help patients a…

This study explores whether offering HIV prevention medication (PrEP) through pharmacies can help more young women aged 18-24 in Tanzania access and consistently use it. Researchers compare four different pharmacy-based service models to standard care, and later test cost-sharing…

This study tests a new way to help young people (ages 13-24) stick with PrEP, a medication that prevents HIV. Participants get PrEP delivered to a community spot (like home or a mobile van) and use a smartphone app for reminders and support. The goal is to see if this combo impro…

This study looks at whether a one-on-one coaching method called academic detailing can help pediatricians feel more comfortable prescribing PrEP, a daily pill that prevents HIV. Fifty doctors will take part in brief, interactive sessions with a trained educator. The goal is to se…

This study tests whether eptinezumab, a drug used for migraines, can reduce the number of headache days in adults with idiopathic intracranial hypertension (IIH), a condition where high fluid pressure around the brain causes severe headaches. About 96 women aged 18-55 with chroni…

This study explores whether ultrasound measurements of the eye can detect changes in brain pressure during laparoscopic gallbladder surgery. The surgery uses carbon dioxide gas to inflate the abdomen, which may affect pressure inside the skull. Researchers will compare two differ…

This study tests whether measuring the optic nerve sheath diameter — the nerve that connects the eye to the brain — with a simple bedside ultrasound can predict a dangerous rise in brain pressure when a pressure-lowering drug (mannitol) is reduced or stopped. Researchers will fol…

This study looks at how a long-acting injectable HIV prevention drug (CAB-LA) and hormonal birth control methods (like the shot or implant) affect each other in women. About 105 women who already use CAB-LA or no HIV prevention will join groups based on their contraceptive choice…

This study will test whether using ultrasound to guide how a patient's head is tilted can improve blood flow to the brain. Researchers will measure brain pressure and blood flow in 30 ICU patients as they are moved from lying flat to a 30-degree angle. The goal is to find a perso…

This trial tests whether remifentanil or esmolol is better at preventing dangerous pressure spikes in the brain when a breathing tube is inserted. Patients with unruptured brain aneurysms scheduled for coil embolization will receive one of the two drugs before intubation. Researc…

This study tests two strategies for removing an external ventricular drain (a tube that drains fluid from the brain) in 170 adults who had a brain bleed. One method clamps the drain shut as soon as it's safe, while the other gradually raises the drain over time. The goal is to se…

This study looks at whether placing a catheter in a neck vein changes pressure inside the skull. Researchers will use ultrasound to measure the optic nerve sheath and carotid artery in 61 adults under general anesthesia. The goal is to understand short-term effects, not to test a…

This study evaluates a program that sends family doctors and nurse practitioners a confidential report comparing their antibiotic prescribing to peers, along with an educational summary. Over 7,600 practitioners in British Columbia will be randomly assigned to receive the report …

This study looks at whether different types of exercise (like walking or strength moves) and timing (morning vs. evening) can safely lower blood pressure in people with glaucoma and high blood pressure. About 60 adults will try four exercise sessions, and their blood pressure and…

This study aims to translate and validate the KOOS-ACL questionnaire for Italian-speaking patients who have had anterior cruciate ligament (ACL) reconstruction. Researchers will enroll 120 native Italian speakers aged 18 or older to test the accuracy and cultural relevance of the…

This study will test if a simple eye ultrasound can measure brain pressure in 60 adults before and after brain tumor surgery. The ultrasound looks at the optic nerve sheath diameter, which may change with pressure. If it works, it could offer a safer, non-invasive alternative to …

This study looks at how different gas pressures used during laparoscopic surgery for gynecologic cancers affect the optic nerve sheath diameter, which is a marker of pressure inside the skull. Researchers will measure this in 100 women aged 18-65 using ultrasound. The goal is to …