Intermediate coronary syndrome

Researchers are testing whether adding bempedoic acid to high-intensity statin and ezetimibe therapy within 72 hours after a heart procedure helps adults with acute coronary syndrome reach very low LDL cholesterol. Participants receive either the three-drug combination or the sta…

This study tests a new device called Freesolve, a temporary magnesium scaffold that props open blocked heart arteries and then dissolves over time. About 1,859 people with up to two new blockages will receive either this scaffold or a standard permanent stent. The goal is to see …

This early study tests a device called the A-FLUX Reducer, which is implanted into a vein in the heart to help blood flow. It is for people with chest pain caused by problems in the heart's tiny blood vessels (microvascular dysfunction). The study will enroll 30 adults and focus …

This study tests a new type of heart stent made from magnesium that slowly dissolves over time. It is designed for people with long blockages in their heart arteries. The goal is to see if the stent is safe and works well at keeping arteries open for up to 12 months. About 100 pa…

This early-stage trial tests whether an experimental drug called UDP-003 is safe in healthy volunteers and people with heart disease. Researchers will give single or multiple doses of the drug or a placebo and monitor for side effects. The study includes 84 participants and is th…

This study looks at whether adding oregano and basil leaves to the diet can lower inflammation and improve cholesterol in people who have recently had unstable angina. About 70 participants will eat these herbs and have their blood and urine tested. The goal is to see if these co…

This study looks at two ways to treat blocked heart arteries in people aged 18 to 68. One uses a drug-coated balloon, and the other uses a temporary scaffold. The goal is to see which approach works better over time, with fewer heart problems or need for repeat procedures. About …

This study is testing a special balloon coated with the drug sirolimus to treat blocked heart arteries. The balloon is inflated inside the artery to push the blockage aside and release the drug, which helps prevent the artery from narrowing again. Researchers will follow over 1,1…

This study looks at how different types of aerobic exercise affect blood vessel health in people with ischemic heart disease (such as after a heart attack or angina). Researchers will compare high-intensity interval training with short bursts, long bursts, and moderate-intensity …

This study tests a special balloon coated with two drugs to open blocked heart arteries in people with chest pain or minor heart attacks. The balloon is used instead of placing a new stent. About 30 participants will be followed for 12 months to see if the artery stays open and i…

This early study tests a new vibrating guidewire designed to open completely blocked heart arteries (chronic total occlusions) in people with chronic chest pain that hasn't improved with standard treatments. The wire vibrates at its tip to help cross the blockage during a procedu…

This phase 3 trial is testing whether two drugs—colchicine (used for gout) and ticagrelor (a blood thinner)—can prevent future strokes, heart attacks, and other vascular events in people who have already had a stroke. About 2,800 high-risk participants will be enrolled. The goal …

This study aims to create a non-invasive diagnostic algorithm using PET imaging and CT scans to identify microvascular angina in patients who have chest pain and signs of ischemia but no blocked coronary arteries. About 70 participants with symptoms of angina or shortness of brea…

This study is testing whether artificial intelligence (AI) can predict or rule out a heart attack using data from standard blood tests. Researchers will analyze white blood cell properties from over 3,000 adults who come to the hospital with chest pain. The goal is to see if AI c…

This study tests whether artificial intelligence and special ECG monitoring can improve diagnosis of angina in people whose arteries are not blocked. Researchers will use a Holter monitor at home and an internal ECG during a procedure to detect subtle signs of heart muscle strain…

This study tests a new, noninvasive device that uses ultra-sensitive magnetocardiography to detect heart attacks. Researchers will enroll nearly 4,000 healthy volunteers and chest pain patients to see if this magnetic scan can identify heart damage more accurately than current me…

This study tests if fexuprazan can prevent upper stomach bleeding in 400 heart patients at high risk for bleeding who must take two blood thinners after getting a heart stent. Participants receive either fexuprazan or the standard drug lansoprazole daily for 6 months. The goal is…

This study compares two common types of heart medications—beta-blockers and calcium channel blockers—in adults aged 65 and older who have stable angina (chest pain) and at least two other chronic conditions. The goal is to see which drug works better and is easier to tolerate, fo…

This study tests whether a single infusion of a patient's own bone marrow stem cells can reduce chest pain and improve quality of life for people with refractory angina—a severe form of chest pain that doesn't respond to standard treatments. About 110 participants will be randoml…

People admitted for acute coronary syndrome, which includes heart attacks and unstable angina, face a higher risk of dangerous heart rhythms such as sustained ventricular tachycardia and ventricular fibrillation. Hospitals monitor these patients, but the exact rate of these rhyth…

This study looks at 60 people with stable angina who have two blocked heart arteries. During a procedure, doctors will temporarily inflate a tiny balloon inside each stent to reduce blood flow while the patient exercises on a bike. The goal is to measure exactly how much flow red…

This study will enroll 246 people who have had a heart stent but still experience chest pain. Researchers will use a detailed diagnostic approach during a heart catheterization to identify whether the pain is due to new blockages, incomplete treatment, or other issues. The goal i…

This study examines how frailty and other health factors affect the short- and long-term outlook for people aged 75 and older who are hospitalized for a heart attack or unstable angina. Researchers will compare two treatment approaches—a procedure to open blocked arteries versus …

This study looks at how aging inside our cells might make heart arteries more prone to dangerous plaques. Researchers will measure DNA damage and other aging markers in 300 adults with different types of chest pain or heart attacks. The goal is to find better ways to predict who …

This study looks at people with chest pain (angina) but no major blockages in their heart arteries. During a standard angiogram, doctors will perform an extra diagnostic test to see if it helps guide treatment. Half the participants will have the test results shared with their do…

This study follows 30,000 adults with coronary artery disease to see how different risk factors affect their long-term survival. Researchers will track deaths from any cause and from heart problems specifically. The goal is to better understand what influences outcomes in real-wo…

This study tests whether a two-part approach—improving communication about viral infections and having pharmacists double-check prescription lengths—can reduce how many days antibiotics are prescribed for respiratory infections like bronchitis, sinusitis, and sore throat. About 4…

This study looks at whether people having urgent heart catheterization need to fast beforehand. 400 patients with chest pain or mild heart attacks will be randomly assigned to either fast as usual or eat and drink normally. Researchers will measure comfort and safety to see if sk…

This study reviews medical records of 200 adults who came to the ER with a heart attack or unstable chest pain. It compares what happens when patients get two blood thinners (aspirin plus another) in the ER versus waiting to give the second one in the catheterization lab. The goa…

This study is testing whether a smartwatch, combined with artificial intelligence and remote doctor check-ins, can help detect heart issues like atrial fibrillation and unstable angina earlier than usual. Researchers at the University of Sao Paulo will enroll 520 adults with hear…