New test during angiography could unlock better care for hidden heart pain
NCT ID NCT04674449
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looks at people with chest pain (angina) but no major blockages in their heart arteries. During a standard angiogram, doctors will perform an extra diagnostic test to see if it helps guide treatment. Half the participants will have the test results shared with their doctor, while the other half will not. The goal is to see if this approach improves symptoms, quality of life, and heart health over time.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Interventional diagnostic procedure (IDP) during coronary angiography
- What this could lead to
- If successful, this could show that a simple diagnostic test during angiography helps doctors choose better treatments for people with chest pain but no blocked arteries.
- What could go wrong
- This is an early-stage study focused on diagnosis and treatment guidance, not a cure. The test may not improve symptoms or outcomes, and there are small risks from the procedure itself.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 1,500 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Dec 2020
- Expected to finish
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Dec 2030
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. Age ≥18 years. 2. A clinical plan for invasive coronary angiography. 3. Symptoms of angina (typical or atypical) according to the Rose- and/or Seattle Angina questionnaires. 4. Able to comply with study procedures. 5. Able to provide informed consent. Exclusion Criteria: 1. A non-coronary primary indication for invasive angiography (e.g. valve disease, heart failure). 2. History of coronary artery bypass surgery. 3. Presence of obstructive disease evident in a main coronary artery (diameter \>2.5 mm), i.e. a coronary stenosis \>50% and/or a fractional flow reserve (FFR) ≤0.80\*. 4. Logistical reason\*. \*These patients will enter a follow-up registry.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
31 sites in 3 countries. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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5th Military Hospital
RECRUITINGKrakow, Poland
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Aberdeen Royal Hospital
COMPLETEDAberdeen, United Kingdom
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Barts Health NHS Trust - St. Bartholomew's Hospital
ACTIVE_NOT_RECRUITINGLondon, United Kingdom
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Basildon University Hospital - Essex Cardiothoracic Centre
COMPLETEDBasildon, United Kingdom
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Bedford Hospital NHS Trust
RECRUITINGBedford, United Kingdom
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Birmingham Heartlands Hospital
RECRUITINGBirmingham, United Kingdom
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Glan Clwyd Hospital
RECRUITINGBodelwyddan, United Kingdom
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Golden Jubilee National Hospital
RECRUITINGClydebank, Scotland, G814DY, United Kingdom
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King's College Hospital
RECRUITINGLondon, United Kingdom
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Leeds Teaching Hospital NHS Trust
RECRUITINGLeeds, United Kingdom
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Liverpool Heart and Chest Hospital
RECRUITINGLiverpool, United Kingdom
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Mater Private Hospital
COMPLETEDDublin, Ireland
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Mater Private Hsopital
COMPLETEDCork, Ireland
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Morriston Hospital
RECRUITINGSwansea, United Kingdom
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NHS Greater Glasgow and Clyde
NOT_YET_RECRUITINGGlasgow, United Kingdom
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New Cross Hospital
RECRUITINGWolverhampton, United Kingdom
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Northern General Hospital
RECRUITINGSheffield, United Kingdom
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Northwick Park Hospital
RECRUITINGLondon, United Kingdom
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Nottingham University Hospitals NHS TRUST
RECRUITINGNottingham, United Kingdom
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Pinderfields General Hospital
RECRUITINGWakefield, United Kingdom
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Queen Alexandra Hospital
RECRUITINGPortsmouth, United Kingdom
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Radboud University Medical Centre
RECRUITINGNijmegen, Netherlands
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Raigmore Hospital
RECRUITINGInverness, United Kingdom
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Royal Blackburn Teaching Hospital
RECRUITINGBlackburn, United Kingdom
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Royal Bournemouth Hospital
COMPLETEDBournemouth, United Kingdom
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Royal Free Hospital
RECRUITINGLondon, NW3, United Kingdom
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Royal Gwent Hospital
RECRUITINGNewport, United Kingdom
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Royal Papworth Hospital NHS Foundation Trust
ACTIVE_NOT_RECRUITINGCambridge, United Kingdom
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Royal Victoria Hospital
RECRUITINGBelfast, United Kingdom
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South Tyneside and Sunderland NHS Foundation Trust
RECRUITINGSunderland, United Kingdom
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St Peter's Hospital NHS Foundation Trust
RECRUITINGChertsey, United Kingdom
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The Newcastle upon Tyne Hospitals NHS Foundation Trust
RECRUITINGNewcastle upon Tyne, United Kingdom
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University Hospital Hairmyres
RECRUITINGEast Kilbride, United Kingdom
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University Hospital Southampton
RECRUITINGSouthampton, United Kingdom
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University Hospital of Wales
RECRUITINGCardiff, United Kingdom
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University Hospitals Coventry & Warwickshire NHS Trust
RECRUITINGCoventry, United Kingdom
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Victoria Hospital
RECRUITINGBlackpool, United Kingdom
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Watford general Hospital
COMPLETEDWatford, United Kingdom
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William Harvey Hospital
RECRUITINGAshford, United Kingdom
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