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New test during angiography could unlock better care for hidden heart pain

NCT ID NCT04674449

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at people with chest pain (angina) but no major blockages in their heart arteries. During a standard angiogram, doctors will perform an extra diagnostic test to see if it helps guide treatment. Half the participants will have the test results shared with their doctor, while the other half will not. The goal is to see if this approach improves symptoms, quality of life, and heart health over time.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Interventional diagnostic procedure (IDP) during coronary angiography
What this could lead to
If successful, this could show that a simple diagnostic test during angiography helps doctors choose better treatments for people with chest pain but no blocked arteries.
What could go wrong
This is an early-stage study focused on diagnosis and treatment guidance, not a cure. The test may not improve symptoms or outcomes, and there are small risks from the procedure itself.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 1,500 people

The number the study aims to enrol. It can still change while the study runs.

Started

Dec 2020

Expected to finish

Dec 2030

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Age ≥18 years. 2. A clinical plan for invasive coronary angiography. 3. Symptoms of angina (typical or atypical) according to the Rose- and/or Seattle Angina questionnaires. 4. Able to comply with study procedures. 5. Able to provide informed consent. Exclusion Criteria: 1. A non-coronary primary indication for invasive angiography (e.g. valve disease, heart failure). 2. History of coronary artery bypass surgery. 3. Presence of obstructive disease evident in a main coronary artery (diameter \>2.5 mm), i.e. a coronary stenosis \>50% and/or a fractional flow reserve (FFR) ≤0.80\*. 4. Logistical reason\*. \*These patients will enter a follow-up registry.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    31 sites in 3 countries. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • 5th Military Hospital

    RECRUITING

    Krakow, Poland

  • Aberdeen Royal Hospital

    COMPLETED

    Aberdeen, United Kingdom

  • Barts Health NHS Trust - St. Bartholomew's Hospital

    ACTIVE_NOT_RECRUITING

    London, United Kingdom

  • Basildon University Hospital - Essex Cardiothoracic Centre

    COMPLETED

    Basildon, United Kingdom

  • Bedford Hospital NHS Trust

    RECRUITING

    Bedford, United Kingdom

  • Birmingham Heartlands Hospital

    RECRUITING

    Birmingham, United Kingdom

  • Glan Clwyd Hospital

    RECRUITING

    Bodelwyddan, United Kingdom

  • Golden Jubilee National Hospital

    RECRUITING

    Clydebank, Scotland, G814DY, United Kingdom

  • King's College Hospital

    RECRUITING

    London, United Kingdom

  • Leeds Teaching Hospital NHS Trust

    RECRUITING

    Leeds, United Kingdom

  • Liverpool Heart and Chest Hospital

    RECRUITING

    Liverpool, United Kingdom

  • Mater Private Hospital

    COMPLETED

    Dublin, Ireland

  • Mater Private Hsopital

    COMPLETED

    Cork, Ireland

  • Morriston Hospital

    RECRUITING

    Swansea, United Kingdom

  • NHS Greater Glasgow and Clyde

    NOT_YET_RECRUITING

    Glasgow, United Kingdom

  • New Cross Hospital

    RECRUITING

    Wolverhampton, United Kingdom

  • Northern General Hospital

    RECRUITING

    Sheffield, United Kingdom

  • Northwick Park Hospital

    RECRUITING

    London, United Kingdom

  • Nottingham University Hospitals NHS TRUST

    RECRUITING

    Nottingham, United Kingdom

  • Pinderfields General Hospital

    RECRUITING

    Wakefield, United Kingdom

  • Queen Alexandra Hospital

    RECRUITING

    Portsmouth, United Kingdom

  • Radboud University Medical Centre

    RECRUITING

    Nijmegen, Netherlands

  • Raigmore Hospital

    RECRUITING

    Inverness, United Kingdom

  • Royal Blackburn Teaching Hospital

    RECRUITING

    Blackburn, United Kingdom

  • Royal Bournemouth Hospital

    COMPLETED

    Bournemouth, United Kingdom

  • Royal Free Hospital

    RECRUITING

    London, NW3, United Kingdom

  • Royal Gwent Hospital

    RECRUITING

    Newport, United Kingdom

  • Royal Papworth Hospital NHS Foundation Trust

    ACTIVE_NOT_RECRUITING

    Cambridge, United Kingdom

  • Royal Victoria Hospital

    RECRUITING

    Belfast, United Kingdom

  • South Tyneside and Sunderland NHS Foundation Trust

    RECRUITING

    Sunderland, United Kingdom

  • St Peter's Hospital NHS Foundation Trust

    RECRUITING

    Chertsey, United Kingdom

  • The Newcastle upon Tyne Hospitals NHS Foundation Trust

    RECRUITING

    Newcastle upon Tyne, United Kingdom

  • University Hospital Hairmyres

    RECRUITING

    East Kilbride, United Kingdom

  • University Hospital Southampton

    RECRUITING

    Southampton, United Kingdom

  • University Hospital of Wales

    RECRUITING

    Cardiff, United Kingdom

  • University Hospitals Coventry & Warwickshire NHS Trust

    RECRUITING

    Coventry, United Kingdom

  • Victoria Hospital

    RECRUITING

    Blackpool, United Kingdom

  • Watford general Hospital

    COMPLETED

    Watford, United Kingdom

  • William Harvey Hospital

    RECRUITING

    Ashford, United Kingdom

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