Inherited primary ovarian failure
MONDO:0019852An instance of primary ovarian failure that is caused by an inherited modification of the individual's genome.
Also known as: hereditary primary ovarian failure, inherited POI, inherited premature ovarian failure, inherited primary ovarian insufficiency, non-acquired premature ovarian failure
52 clinical trials for this condition and its sub-types, 2 tagged with Inherited primary ovarian failure itself.
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Sub-types of Inherited primary ovarian failure
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Turner syndrome 28 trials
3 sub-types
- Turner syndrome due to structural X chromosome anomalies 0 trials
- Mixed gonadal dysgenesis 0 trials
- Monosomy X 0 trials Sub-types →
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Ataxia telangiectasia 11 trials
1 sub-type
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Classic galactosemia 3 trials
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Trisomy X 3 trials
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46 XX gonadal dysgenesis 1 trial
11 sub-types
- SERKAL syndrome 0 trials
- Ovarian dysgenesis 1 0 trials
- Ovarian dysgenesis 10 0 trials
- Ovarian dysgenesis 11 0 trials
- Ovarian dysgenesis 2 0 trials
- Ovarian dysgenesis 3 0 trials
- Ovarian dysgenesis 5 0 trials
- Ovarian dysgenesis 6 0 trials
- Ovarian dysgenesis 7 0 trials
- Ovarian dysgenesis 8 0 trials
- Ovarian dysgenesis 9 0 trials
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Premature ovarian failure 1 1 trial
1 sub-type
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Perrault syndrome 0 trials
7 sub-types
- Perrault syndrome 1 0 trials
- Perrault syndrome 2 0 trials
- Perrault syndrome 3 0 trials
- Perrault syndrome 4 0 trials
- Perrault syndrome 5 0 trials
- Perrault syndrome 6 0 trials
- Perrault syndrome 7 0 trials
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Satoyoshi syndrome 0 trials
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X small rings 0 trials
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Aromatase deficiency 0 trials
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5 sub-types
- Blepharophimosis-epicanthus inversus-ptosis due to 3q23 rearrangement syndrome 0 trials
- Blepharophimosis-epicanthus inversus-ptosis due to a point mutation syndrome 0 trials
- Blepharophimosis-epicanthus inversus-ptosis due to copy number variations 0 trials
- Blepharophimosis-ptosis-epicanthus inversus syndrome type 1 0 trials
- Blepharophimosis-ptosis-epicanthus inversus syndrome type 2 0 trials
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Premature ovarian failure 10 0 trials
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Premature ovarian failure 11 0 trials
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Premature ovarian failure 12 0 trials
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Premature ovarian failure 13 0 trials
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Premature ovarian failure 14 0 trials
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Premature ovarian failure 15 0 trials
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Premature ovarian failure 16 0 trials
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Premature ovarian failure 17 0 trials
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Premature ovarian failure 18 0 trials
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Premature ovarian failure 19 0 trials
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Premature ovarian failure 20 0 trials
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Premature ovarian failure 21 0 trials
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Premature ovarian failure 22 0 trials
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Premature ovarian failure 23 0 trials
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Premature ovarian failure 24 0 trials
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Premature ovarian failure 25 0 trials
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Premature ovarian failure 26 0 trials
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Premature ovarian failure 2A 0 trials
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Premature ovarian failure 2B 0 trials
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Premature ovarian failure 3 0 trials
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Premature ovarian failure 4 0 trials
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Premature ovarian failure 5 0 trials
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Premature ovarian failure 6 0 trials
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Premature ovarian failure 7 0 trials
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Premature ovarian failure 8 0 trials
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Premature ovarian failure 9 0 trials
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Tetrasomy X 0 trials
Most studied deeper sub-types
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Frozen ovary tissue awakened to restore fertility in women with early menopause
Disease control CompletedThis study tested a new technique to help women with primary ovarian insufficiency (early ovarian failure) become pregnant. Doctors removed one ovary, treated small pieces of it with drugs to wake up dormant eggs, and then transplanted the tissue back into the patient. After moni…
Sponsor: The First Affiliated Hospital of Zhengzhou University • Aim: Disease control
Last updated Jun 27, 2026 12:38 UTC
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Could red blood cells deliver a steroid to ease a rare brain disorder?
Disease control CompletedThis Phase 3 trial tested a treatment called EryDex for people with ataxia telangiectasia (A-T), a rare genetic disease that affects movement and coordination. EryDex is a steroid (dexamethasone) packaged inside the patient's own red blood cells and given as an IV infusion every …
Phase 3 • Sponsor: Quince Therapeutics S.p.A. • Aim: Disease control
Last updated Jun 27, 2026 12:25 UTC
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Fertility boost? study tests estradiol and guaifenesin alongside clomiphene
Disease control CompletedThis study looked at whether adding vaginal estradiol or oral guaifenesin to standard fertility treatment (clomiphene citrate) could improve pregnancy rates. 90 women with infertility were randomly assigned to one of three groups. The goal was to see if these add-ons helped with …
Sponsor: Yuzuncu Yil University • Aim: Disease control
Last updated Jun 27, 2026 09:03 UTC
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New hope for kids with rare sugar disorder: drug shows promise in trial
Disease control CompletedThis study tested an experimental drug called AT-007 in 47 children aged 2 to 18 with Classic Galactosemia, a rare genetic disorder that makes it hard to break down a sugar called galactose. The goal was to see if the drug could improve behavior, daily living skills, and language…
Phase 2/3 • Sponsor: Applied Therapeutics, Inc. • Aim: Disease control
Last updated Jun 27, 2026 07:55 UTC
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Babble boot camp: could early talk therapy stop speech delays in rare disease?
Prevention CompletedThis study tested a program called Babble Boot Camp for babies with classic galactosemia, a rare condition that often causes speech and language problems. The program started when babies were 2 to 24 months old and involved weekly online coaching for parents from a speech therapi…
Early phase 1 • Sponsor: Arizona State University • Aim: Prevention
Last updated Jun 27, 2026 08:13 UTC
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Can an immune drug slow a rare childhood brain disease?
Symptom relief CompletedAtaxia-telangiectasia is a rare, inherited disease that damages the nervous system, skin, and immune system, and it has no cure. Researchers are testing sirolimus, an immune-suppressing drug, in children under 17 with the condition. The six participants take sirolimus by mouth fo…
Phase 2 • Sponsor: Sara Elva Espinosa Padilla, MD • Aim: Symptom relief
Last updated Sep 17, 2026 00:00 UTC
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Can brain tests unlock the social struggles of turner syndrome?
Knowledge-focused CompletedThis study investigates why some girls with Turner syndrome find it hard to make friends, read emotions, and control their feelings. Researchers will compare 35 girls with Turner syndrome to 35 girls with isolated growth hormone deficiency, all aged 7 to 16. Through puzzles, memo…
Sponsor: University Hospital, Angers • Aim: Knowledge-focused
Last updated Aug 20, 2026 00:00 UTC
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Scientists dig into the mysteries of x and y chromosomes
Knowledge-focused CompletedThis study looked at 112 people with known differences in their sex chromosomes (X and Y) to better understand how these variations affect health, especially infertility. Participants underwent physical exams, blood and urine tests, imaging, and sensory checks over about 5 days. …
Sponsor: National Human Genome Research Institute (NHGRI) • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:07 UTC
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Large study looks at how a 25-Gene cancer test affects patients and families
Knowledge-focused CompletedThis study looked at how a genetic test that checks 25 genes linked to hereditary cancers is used in clinics. Over 1,500 people with a personal or family history of cancer took part. Researchers collected blood samples and had participants fill out questionnaires over five years …
Sponsor: University of Southern California • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:06 UTC
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Can a simple uterine flush boost IVF pregnancy rates?
Knowledge-focused CompletedThis study looked at whether flushing the uterus with a low dose of the hormone hCG right after egg retrieval could improve pregnancy rates in women undergoing IVF. Researchers measured immune markers and blood flow in the uterus to see if the flush made the womb more receptive t…
Phase 4 • Sponsor: Omayma Ismail Khalaf • Aim: Knowledge-focused
Last updated Jun 26, 2026 18:57 UTC