Inherited primary ovarian failure
MONDO:0019852An instance of primary ovarian failure that is caused by an inherited modification of the individual's genome.
Also known as: hereditary primary ovarian failure, inherited POI, inherited premature ovarian failure, inherited primary ovarian insufficiency, non-acquired premature ovarian failure
53 clinical trials for this condition and its sub-types, 2 tagged with Inherited primary ovarian failure itself.
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Sub-types of Inherited primary ovarian failure
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Turner syndrome 29 trials
3 sub-types
- Turner syndrome due to structural X chromosome anomalies 0 trials
- Mixed gonadal dysgenesis 0 trials
- Monosomy X 0 trials Sub-types →
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Ataxia telangiectasia 11 trials
1 sub-type
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Classic galactosemia 3 trials
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Trisomy X 3 trials
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46 XX gonadal dysgenesis 1 trial
11 sub-types
- SERKAL syndrome 0 trials
- Ovarian dysgenesis 1 0 trials
- Ovarian dysgenesis 10 0 trials
- Ovarian dysgenesis 11 0 trials
- Ovarian dysgenesis 2 0 trials
- Ovarian dysgenesis 3 0 trials
- Ovarian dysgenesis 5 0 trials
- Ovarian dysgenesis 6 0 trials
- Ovarian dysgenesis 7 0 trials
- Ovarian dysgenesis 8 0 trials
- Ovarian dysgenesis 9 0 trials
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Premature ovarian failure 1 1 trial
1 sub-type
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Perrault syndrome 0 trials
7 sub-types
- Perrault syndrome 1 0 trials
- Perrault syndrome 2 0 trials
- Perrault syndrome 3 0 trials
- Perrault syndrome 4 0 trials
- Perrault syndrome 5 0 trials
- Perrault syndrome 6 0 trials
- Perrault syndrome 7 0 trials
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Satoyoshi syndrome 0 trials
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X small rings 0 trials
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Aromatase deficiency 0 trials
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5 sub-types
- Blepharophimosis-epicanthus inversus-ptosis due to 3q23 rearrangement syndrome 0 trials
- Blepharophimosis-epicanthus inversus-ptosis due to a point mutation syndrome 0 trials
- Blepharophimosis-epicanthus inversus-ptosis due to copy number variations 0 trials
- Blepharophimosis-ptosis-epicanthus inversus syndrome type 1 0 trials
- Blepharophimosis-ptosis-epicanthus inversus syndrome type 2 0 trials
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Premature ovarian failure 10 0 trials
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Premature ovarian failure 11 0 trials
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Premature ovarian failure 12 0 trials
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Premature ovarian failure 13 0 trials
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Premature ovarian failure 14 0 trials
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Premature ovarian failure 15 0 trials
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Premature ovarian failure 16 0 trials
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Premature ovarian failure 17 0 trials
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Premature ovarian failure 18 0 trials
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Premature ovarian failure 19 0 trials
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Premature ovarian failure 20 0 trials
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Premature ovarian failure 21 0 trials
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Premature ovarian failure 22 0 trials
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Premature ovarian failure 23 0 trials
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Premature ovarian failure 24 0 trials
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Premature ovarian failure 25 0 trials
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Premature ovarian failure 26 0 trials
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Premature ovarian failure 2A 0 trials
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Premature ovarian failure 2B 0 trials
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Premature ovarian failure 3 0 trials
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Premature ovarian failure 4 0 trials
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Premature ovarian failure 5 0 trials
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Premature ovarian failure 6 0 trials
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Premature ovarian failure 7 0 trials
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Premature ovarian failure 8 0 trials
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Premature ovarian failure 9 0 trials
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Tetrasomy X 0 trials
Most studied deeper sub-types
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Can a tiny estradiol patch boost brain speed in turner syndrome?
Disease control Not yet recruitingThis study tests whether ultra-low dose estradiol patches, started between ages 8 and 11.5, are safe and may improve thinking speed and short-term memory in girls with Turner syndrome who have ovarian failure. Participants wear a small fraction of a standard patch, changed weekly…
Phase 2 • Sponsor: Children's National Research Institute • Aim: Disease control
Last updated Aug 27, 2026 00:00 UTC
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IVF Needle-Free? oral pill tested as injection alternative
Disease control Not yet recruitingThis trial tests whether an oral medication called linzagolix can replace daily injections used to prevent premature ovulation during in vitro fertilization (IVF). The study compares the number of mature eggs retrieved in women taking the pill versus those receiving standard inje…
Sponsor: Centro A.M.B.R.A. (Associazione Medici e Biologi per la Riproduzione Assistita) • Aim: Disease control
Last updated Aug 05, 2026 00:00 UTC
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Estrogen showdown: gel or pill for turner syndrome puberty?
Disease control Not yet recruitingThis trial tests two ways of giving estrogen to girls and young women with Turner syndrome to help them start puberty. Participants will be randomly assigned to use either an estrogen gel applied to the skin or an estrogen tablet taken by mouth for 19 months. The study will compa…
Phase 2 • Sponsor: Universiti Kebangsaan Malaysia Medical Centre • Aim: Disease control
Last updated Jun 27, 2026 09:01 UTC
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Could a single infusion restart ovaries in early menopause?
Disease control Not yet recruitingThis early-stage study tests a new drug called YB-1113 for women with premature ovarian insufficiency (early menopause). The goal is to see if it is safe and can help restart ovarian function, potentially allowing women under 40 to become pregnant. Only 6 participants will receiv…
Phase 1 • Sponsor: Bright Cell, Inc. • Aim: Disease control
Last updated Jun 27, 2026 08:06 UTC
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New therapy aims to ease grief after miscarriage or stillbirth
Symptom relief Not yet recruitingThis pilot study tests a 4-week program based on acceptance and commitment therapy (ACT) for women who have experienced a miscarriage, stillbirth, or newborn death within the past year. The program includes six sessions plus a booster, combining in-person and video meetings. Rese…
Sponsor: Second Xiangya Hospital of Central South University • Aim: Symptom relief
Last updated Jun 27, 2026 12:26 UTC
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Could hidden blood problems be common in children with certain genetic syndromes?
Knowledge-focused Not yet recruitingThis study looks at blood health in children with numerical chromosomal disorders, such as Down syndrome, Turner syndrome, Klinefelter syndrome, Edwards syndrome, and Patau syndrome. Researchers will measure blood counts and check for issues like anemia, low platelets, or abnorma…
Sponsor: Assiut University • Aim: Knowledge-focused
Last updated Sep 12, 2026 00:00 UTC
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Do rare conditions affect sexual Well-Being? a study investigates
Knowledge-focused Not yet recruitingThis study asks whether women with lipodystrophy syndromes or Turner syndrome experience lower sexual quality of life than women in the general population. Researchers will compare survey responses from affected women with those from a large French cohort. The goal is to understa…
Sponsor: Assistance Publique - Hôpitaux de Paris • Aim: Knowledge-focused
Last updated Sep 04, 2026 00:00 UTC
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Could early markers unlock treatments for a rare childhood disease?
Knowledge-focused Not yet recruitingThis study follows babies and young children (up to age 5) who have a genetic diagnosis of ataxia telangiectasia (A-T), a rare disease that affects movement and immunity. Researchers use brain and lung scans, blood tests, and movement analysis to spot early signs of disease progr…
Sponsor: University of Nottingham • Aim: Knowledge-focused
Last updated Jul 18, 2026 00:00 UTC
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Major study to uncover cancer Treatment's hidden toll on fertility
Knowledge-focused Not yet recruitingThis study will follow 3,000 young women (ages 15-39) with cancer to understand how treatments like chemotherapy and immunotherapy impact their fertility, pregnancy outcomes, and quality of life. Researchers will also look at the safety and success of fertility preservation metho…
Sponsor: Karolinska Institutet • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:01 UTC