Inherited primary ovarian failure
MONDO:0019852An instance of primary ovarian failure that is caused by an inherited modification of the individual's genome.
Also known as: hereditary primary ovarian failure, inherited POI, inherited premature ovarian failure, inherited primary ovarian insufficiency, non-acquired premature ovarian failure
52 clinical trials for this condition and its sub-types, 2 tagged with Inherited primary ovarian failure itself.
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Sub-types of Inherited primary ovarian failure
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Turner syndrome 28 trials
3 sub-types
- Turner syndrome due to structural X chromosome anomalies 0 trials
- Mixed gonadal dysgenesis 0 trials
- Monosomy X 0 trials Sub-types →
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Ataxia telangiectasia 11 trials
1 sub-type
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Classic galactosemia 3 trials
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Trisomy X 3 trials
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46 XX gonadal dysgenesis 1 trial
11 sub-types
- SERKAL syndrome 0 trials
- Ovarian dysgenesis 1 0 trials
- Ovarian dysgenesis 10 0 trials
- Ovarian dysgenesis 11 0 trials
- Ovarian dysgenesis 2 0 trials
- Ovarian dysgenesis 3 0 trials
- Ovarian dysgenesis 5 0 trials
- Ovarian dysgenesis 6 0 trials
- Ovarian dysgenesis 7 0 trials
- Ovarian dysgenesis 8 0 trials
- Ovarian dysgenesis 9 0 trials
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Premature ovarian failure 1 1 trial
1 sub-type
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Perrault syndrome 0 trials
7 sub-types
- Perrault syndrome 1 0 trials
- Perrault syndrome 2 0 trials
- Perrault syndrome 3 0 trials
- Perrault syndrome 4 0 trials
- Perrault syndrome 5 0 trials
- Perrault syndrome 6 0 trials
- Perrault syndrome 7 0 trials
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Satoyoshi syndrome 0 trials
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X small rings 0 trials
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Aromatase deficiency 0 trials
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5 sub-types
- Blepharophimosis-epicanthus inversus-ptosis due to 3q23 rearrangement syndrome 0 trials
- Blepharophimosis-epicanthus inversus-ptosis due to a point mutation syndrome 0 trials
- Blepharophimosis-epicanthus inversus-ptosis due to copy number variations 0 trials
- Blepharophimosis-ptosis-epicanthus inversus syndrome type 1 0 trials
- Blepharophimosis-ptosis-epicanthus inversus syndrome type 2 0 trials
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Premature ovarian failure 10 0 trials
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Premature ovarian failure 11 0 trials
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Premature ovarian failure 12 0 trials
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Premature ovarian failure 13 0 trials
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Premature ovarian failure 14 0 trials
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Premature ovarian failure 15 0 trials
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Premature ovarian failure 16 0 trials
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Premature ovarian failure 17 0 trials
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Premature ovarian failure 18 0 trials
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Premature ovarian failure 19 0 trials
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Premature ovarian failure 20 0 trials
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Premature ovarian failure 21 0 trials
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Premature ovarian failure 22 0 trials
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Premature ovarian failure 23 0 trials
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Premature ovarian failure 24 0 trials
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Premature ovarian failure 25 0 trials
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Premature ovarian failure 26 0 trials
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Premature ovarian failure 2A 0 trials
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Premature ovarian failure 2B 0 trials
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Premature ovarian failure 3 0 trials
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Premature ovarian failure 4 0 trials
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Premature ovarian failure 5 0 trials
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Premature ovarian failure 6 0 trials
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Premature ovarian failure 7 0 trials
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Premature ovarian failure 8 0 trials
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Premature ovarian failure 9 0 trials
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Tetrasomy X 0 trials
Most studied deeper sub-types
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Weekly shot may help short kids grow – new study underway
Disease control OngoingThis study tests a new growth hormone medicine called somapacitan, given once a week, in 47 children who are very short due to being born small for gestational age, or having Turner syndrome, Noonan syndrome, or idiopathic short stature. The main goal is to see if it is safe and …
Phase 3 • Sponsor: Novo Nordisk A/S • Aim: Disease control
Last updated Aug 15, 2026 00:00 UTC
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Can early parent coaching help infants with rare genetic disorders thrive?
Disease control By invitation onlyThis study tests a program called PIXI that coaches parents of infants diagnosed with rare neurogenetic disorders (such as Fragile X, Angelman, or Down syndrome) during the first year of life. The program combines education about the disorder, guided parent-child interaction acti…
Sponsor: RTI International • Aim: Disease control
Last updated Jul 15, 2026 00:00 UTC
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Weekly shot could replace daily needles for kids with growth disorders
Disease control OngoingThis study tests if a new growth hormone medicine (somapacitan) given once a week works as well as the standard daily growth hormone (Norditropin) for children who are very short due to being born small, or having Turner syndrome, Noonan syndrome, or unknown causes. About 412 chi…
Phase 3 • Sponsor: Novo Nordisk A/S • Aim: Disease control
Last updated Jun 27, 2026 13:08 UTC
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Weekly shot may replace daily growth hormone for turner syndrome kids
Disease control OngoingThis study tests a new long-acting growth hormone (lonapegsomatropin) given once a week, compared to the standard daily growth hormone shot, in 48 prepubertal children with Turner syndrome who have not had growth hormone before. The goal is to see if the weekly shot is safe and h…
Phase 2 • Sponsor: Ascendis Pharma Endocrinology Division A/S • Aim: Disease control
Last updated Jun 27, 2026 12:33 UTC
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Can freezing ovarian tissue help girls have babies later?
Disease control OngoingThis study offers girls from birth to age 17 the chance to freeze their ovarian tissue before medical treatments that could harm their fertility, such as chemotherapy or radiation. The tissue is removed surgically and stored. Later, if they want to have children, the tissue can b…
Sponsor: Mayo Clinic • Aim: Disease control
Last updated Jun 27, 2026 12:10 UTC
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Newborn screening study aims to catch rare diseases at birth
Diagnosis OngoingThis study offers voluntary screening for newborns in North Carolina to detect a wide range of rare health conditions early. Using a small blood sample already collected at birth, the program tests for dozens of disorders, including spinal muscular atrophy, cystic fibrosis, and m…
Sponsor: RTI International • Aim: Diagnosis
Last updated Jul 03, 2026 00:00 UTC
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New study hopes to outsmart pancreatic cancer by gathering clues
Knowledge-focused OngoingThis study collects health information and test results from 317 people at high risk for pancreatic cancer, including those with cysts, genetic syndromes, or other risk factors. Researchers aim to build a database to find better ways to detect the disease early or prevent it. No …
Sponsor: H. Lee Moffitt Cancer Center and Research Institute • Aim: Knowledge-focused
Last updated Sep 17, 2026 00:00 UTC
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Can ovarian freezing help girls with turner syndrome have children later?
Knowledge-focused OngoingThis study looks at freezing ovarian tissue in girls with Turner syndrome, a condition that often causes early ovary failure and infertility. Researchers want to find out which patients are most likely to have healthy eggs in their tissue by checking their genes, hormones, and me…
Sponsor: Assistance Publique - Hôpitaux de Paris • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:01 UTC
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Scientists hunt for hidden genes behind aortic aneurysms
Knowledge-focused OngoingThis study aims to uncover the genetic roots of aortic aneurysms and valve disease by analyzing tissue and blood samples from 3,000 participants. Researchers will look for new disease-causing genes and factors that affect disease severity. The goal is to build a biorepository to …
Sponsor: Yale University • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:04 UTC
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New study aims to unlock mysteries of sex chromosome disorders in children
Knowledge-focused By invitation onlyThis study follows 300 fetuses and children with sex chromosome disorders to track their growth, organ development, and overall health. Researchers will also look at genetic and gut microbiome factors. The goal is to better understand how these conditions affect children over tim…
Sponsor: University of Aarhus • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:11 UTC
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Scientists probe genetic secrets of lost fetuses to unravel sex chromosome mysteries
Knowledge-focused By invitation onlyThis study looks at fetuses with sex chromosome disorders (like extra or missing X or Y chromosomes) that were either miscarried or electively aborted. Researchers will analyze the placenta and fetal tissues to see how the chromosome changes affect gene activity and development. …
Sponsor: University of Aarhus • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:09 UTC