Infectious encephalitis

This study tests two new mRNA vaccines (GBP560) against Japanese encephalitis, a virus that can cause brain swelling. About 402 healthy adults will receive different doses of the vaccine or a comparison vaccine. Researchers will monitor safety and measure immune responses to find…

This early-phase study tested whether infusing virus-fighting immune cells from a healthy donor could safely treat progressive multifocal leukoencephalopathy (PML), a serious brain infection in people with weak immune systems. Sixty adults with PML received up to three infusions …

This study tested whether adding a powerful HIV drug called FUZEON® to standard antiretroviral therapy could help people with HIV who also have a rare brain infection called PML. PML is caused by a virus that attacks the brain when the immune system is weak. The goal was to see i…

This early-phase study tested a drug called NT-I7 in 12 adults with progressive multifocal leukoencephalopathy (PML), a serious brain infection that occurs in people with weakened immune systems. The goal was to see if NT-I7 could increase the number of infection-fighting white b…

This study examines a rare brain disease called anti-LGI1 encephalitis, where the immune system attacks a protein in the brain, causing memory loss, confusion, and seizures. Researchers will review medical records from 112 patients across five hospitals in Eastern China to see ho…

This completed study tested blood samples from 878 people in Limousin, France, for antibodies against tick-borne encephalitis virus (TBEV). The goal was to see if the virus is present in the region, especially in patients with Lyme disease or neurological symptoms. Researchers al…

This completed study reviewed medical records of 50 obese adults with HSV encephalitis (a brain infection) to see how different ways of calculating acyclovir dose affect survival. Researchers looked at patients treated between 2013 and 2019 at six hospitals. The goal was to find …

This study looks at how a specific gene mutation (RANBP2) affects the immune system in people with Acute Necrotizing Encephalopathy type 1 (ANE1), a rare brain condition triggered by infections. Researchers compared blood samples from 35 participants, including patients with the …

This study looked at how gadolinium, a dye used in MRI scans, changes the QSM signal in the brain's white matter. 73 patients with inflammatory central nervous system conditions had MRI scans before and after receiving gadolinium. The goal was to measure any differences in the si…

This study looked at 22 people with PML, a rare brain infection caused by the JC virus in those with weakened immune systems. Researchers collected blood, urine, and spinal fluid samples over six months to measure immune checkpoint molecules and antiviral responses. The goal was …