Hereditary narcolepsy

This study explores whether a three-dimensional electronic pulse diagnostic device can accurately identify Traditional Chinese Medicine (TCM) syndromes in people with sleep disorders. Participants undergo pulse measurements and symptom assessments, and the device's results are co…

This study compares a new mass spectrometry technique to the standard radioimmunoassay for measuring orexin-A levels in cerebrospinal fluid. Orexin-A is a key brain chemical that is low in people with type 1 narcolepsy. The study involves 117 people with excessive daytime sleepin…

This trial tests whether a nurse-led program of sleep hygiene education and progressive muscle relaxation can improve sleep quality in obese pregnant women. Researchers will enroll 100 women in their third trimester with a BMI of 30 or higher and sleep problems. Half will receive…

This trial tests whether a daily sleep gummy can improve sleep quality and quantity in adults aged 20-50 who have self-reported sleep issues. Participants take one gummy before bed for 7 days while wearing a Fitbit tracker to measure sleep patterns. The study compares sleep metri…

This trial tests whether different combinations of cannabinoids—THC, CBN, CBG, CBD, and melatonin—taken as gummies can improve sleep quality in adults aged 21 to 55 who report poor sleep. Participants will be randomly assigned to receive one of several active gummy formulas or a …

This trial tests whether a set of EMF protection devices—including pads, chips, and bands—can improve sleep quality and energy levels in adults aged 30-60 who have trouble sleeping. Participants use all devices daily for about four weeks while tracking sleep with a wearable ring …

This study tests whether personalized advice on sleep timing, light exposure, meal times, and physical activity can improve sleep quality in adults aged 65 and older who have poor sleep. Participants are randomly assigned to receive either general sleep advice or a customized pla…

This study tested an experimental drug called AXS-12 (reboxetine) in 90 people with narcolepsy who experience cataplexy (sudden muscle weakness) and excessive daytime sleepiness. Participants took either the drug or a placebo twice daily for several weeks. The main goal was to se…

This study tested a dietary supplement called Speed Sleep in 60 adults aged 18-65 who have trouble sleeping. Participants took either the supplement or a placebo daily for 4 weeks. Sleep quality and quantity were measured using Fitbit trackers and questionnaires.

This study tested whether a daily mix of plant protein and two herbs (ashwagandha and rhodiola) could improve sleep in 100 adults aged 35-70 with sleep troubles. Participants took either the supplement or a placebo for 30 days and reported their sleep quality daily. The goal was …

This early study tested a product called Chenghuang Circadian Rhythm Regulator in 15 adults with ongoing sleep problems. The goal was to see if it could improve sleep quality and immune markers. Results are not yet reported, but the study was small and had no comparison group.

This study tested whether a headband called Muse-S, which senses brain activity, could help midlife women with sleep problems like insomnia. Thirty-one women going through menopause wore the device at home. The goal was to see if it was practical and if it improved sleep quality …

This study tested whether acupressure—a gentle finger-pressure technique on specific body points—could improve sleep in elderly people living in care homes. 75 residents took part, with half receiving 12 acupressure sessions over four weeks. The results showed that those who rece…

This study tested an online program called ALDER that teaches older adults skills to boost positive emotions and reduce anxiety. 33 people aged 65 and older who used benzodiazepines (anti-anxiety or sleep medications) at least twice a week took part. Over 5 weeks, they learned an…

This study looked at the long-term safety and effectiveness of a drug called AXS-12 for people with narcolepsy who also have sudden muscle weakness (cataplexy) and severe daytime sleepiness. 68 people who had already completed an earlier study took AXS-12 and were monitored for s…

This study tested a sleep and circadian treatment (TranS-C) for people with severe mental illness (SMI) in community mental health centers. The treatment was adapted to better fit these settings. Researchers looked at whether it improved sleep, daily functioning, and symptoms in …

This study tested two versions of a sleep treatment for people with severe mental illness in community mental health centers. One version was the standard treatment, and the other was adapted to better fit patients' needs. The goal was to see if training clinic staff to deliver t…

This study tested a new once-nightly medication called FT218 for people with narcolepsy who experience excessive daytime sleepiness and sudden muscle weakness (cataplexy). It included 184 participants, some already on a twice-nightly medication and some new to treatment. The goal…

This study tested a computer system designed to help doctors more accurately diagnose and manage complex brain disorders like dementia, epilepsy, and sleep problems. Researchers collected health data from 635 people visiting specialty clinics, including healthy volunteers, to see…