Head and neck neoplasm
MONDO:0005586A benign or malignant neoplasm that affects the anatomic structures of the head and neck region. Representative examples of benign neoplasms include salivary gland pleomorphic adenoma and nasal cavity papilloma. Representative examples of malignant neoplasms include oral cavity squamous cell carcinoma, laryngeal squamous cell carcinoma, and salivary gland carcinoma.
Also known as: craniocervical region neoplasm, craniocervical region neoplasm (disease), craniocervical region tumor, craniocervical region tumour, head and neck neoplasm, head and neck neoplasm (excluding central nervous system), head and neck tumor, head and neck tumour
3506 clinical trials for this condition and its sub-types, 79 tagged with Head and neck neoplasm itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Part of
Sub-types of Head and neck neoplasm
-
Head and neck cancer 637 trials · 2,004 incl. sub-types
16 sub-types
- Head and neck carcinoma 73 trials · 1,415 incl. sub-types Sub-types →
- Malignant tumor of neck 14 trials · 505 incl. sub-types Sub-types →
- Ocular cancer 10 trials · 168 incl. sub-types Sub-types →
- Salivary gland cancer 62 trials · 81 incl. sub-types Sub-types →
- Skull cancer 0 trials · 38 incl. sub-types Sub-types →
- Tongue cancer 26 trials · 35 incl. sub-types Sub-types →
- Lip cancer 12 trials · 15 incl. sub-types Sub-types →
- Nasal cavity cancer 5 trials · 14 incl. sub-types Sub-types →
- Malignant cranial nerve neoplasm 0 trials · 4 incl. sub-types Sub-types →
- Cheek mucosa cancer 1 trial · 2 incl. sub-types Sub-types →
- Gingival cancer 1 trial · 2 incl. sub-types Sub-types →
- Malignant ear neoplasm 0 trials · 2 incl. sub-types Sub-types →
- Malignant tumor of floor of mouth 0 trials · 2 incl. sub-types Sub-types →
- Hard palate cancer 0 trials · 1 incl. sub-types Sub-types →
- Angiosarcoma of the scalp 0 trials
- Malignant carotid body paraganglioma 0 trials
-
Neoplasm of neck 1 trial · 505 incl. sub-types
4 sub-types
- Malignant tumor of neck 14 trials · 505 incl. sub-types Sub-types →
- Benign neoplasm of neck 0 trials
- Cervical dermoid cyst 0 trials
- Cervical neuroblastoma 0 trials
-
Neoplasm of oropharynx 3 trials · 279 incl. sub-types
2 sub-types
- Oropharynx cancer 149 trials · 279 incl. sub-types Sub-types →
- Benign neoplasm of oropharynx 0 trials
-
Nasopharyngeal neoplasm 37 trials · 226 incl. sub-types
3 sub-types
- Malignant tumor of nasopharynx 9 trials · 213 incl. sub-types Sub-types →
- Benign neoplasm of nasopharynx 0 trials
- Nasopharyngeal teratoma 0 trials
-
Eye neoplasm 3 trials · 192 incl. sub-types
13 sub-types
- Ocular cancer 10 trials · 168 incl. sub-types Sub-types →
- Uvea neoplasm 1 trial · 103 incl. sub-types Sub-types →
- Retina neoplasm 2 trials · 36 incl. sub-types Sub-types →
- Conjunctival tumor 1 trial · 23 incl. sub-types Sub-types →
- Benign neoplasm of eye 0 trials · 19 incl. sub-types Sub-types →
- Cornea neoplasm 0 trials · 17 incl. sub-types Sub-types →
- Eyelid neoplasm 3 trials · 7 incl. sub-types Sub-types →
- Intraocular medulloepithelioma 1 trial
- Ocular surface squamous neoplasia 1 trial
- Combined hamartoma of the retina and retinal pigment epithelium 0 trials
- Lacrimal gland neoplasm 0 trials Sub-types →
- Orbital leiomyoma 0 trials
- Ring dermoid of cornea 0 trials
-
Skull neoplasm 0 trials · 161 incl. sub-types
7 sub-types
- Skull base neoplasm 12 trials · 124 incl. sub-types Sub-types →
- Skull cancer 0 trials · 38 incl. sub-types Sub-types →
- Paranasal sinus neoplasm 5 trials · 29 incl. sub-types Sub-types →
- Neoplasm of jaw 1 trial · 9 incl. sub-types Sub-types →
- Orbit neoplasm 0 trials · 2 incl. sub-types Sub-types →
- Jugular foramen meningioma 0 trials
- Schwannoma of jugular foramen 0 trials
-
Neoplasm of hypopharynx 0 trials · 100 incl. sub-types
3 sub-types
- Hypopharynx cancer 50 trials · 100 incl. sub-types Sub-types →
- Benign neoplasm of hypopharynx 0 trials Sub-types →
- Epiglottis neoplasm 0 trials Sub-types →
-
Tumor of salivary gland 9 trials · 85 incl. sub-types
4 sub-types
- Salivary gland cancer 62 trials · 81 incl. sub-types Sub-types →
- Neoplasm of major salivary gland 0 trials · 17 incl. sub-types Sub-types →
- Benign neoplasm of salivary gland 1 trial · 5 incl. sub-types Sub-types →
- Neoplasm of minor salivary gland 0 trials Sub-types →
-
Nasal cavity and paranasal sinus neoplasm 0 trials · 44 incl. sub-types
1 sub-type
- Nasal cavity and paranasal sinus carcinoma 21 trials · 44 incl. sub-types Sub-types →
-
Tongue neoplasm 2 trials · 35 incl. sub-types
2 sub-types
- Tongue cancer 26 trials · 35 incl. sub-types Sub-types →
- Benign neoplasm of tongue 0 trials
-
Lip neoplasm 1 trial · 15 incl. sub-types
2 sub-types
- Lip cancer 12 trials · 15 incl. sub-types Sub-types →
- Benign neoplasm of lip 0 trials
-
Nasal cavity neoplasm 1 trial · 15 incl. sub-types
3 sub-types
- Nasal cavity cancer 5 trials · 14 incl. sub-types Sub-types →
- Benign neoplasm of nasal cavity 1 trial Sub-types →
- Nasal cavity inverting papilloma 0 trials
-
Benign epithelial tumor of salivary glands 0 trials · 12 incl. sub-types
1 sub-type
- Pleomorphic adenoma 12 trials
-
Recurrent respiratory papillomatosis 8 trials · 9 incl. sub-types
1 sub-type
- Laryngeal papillomatosis 1 trial
-
Cranial nerve neoplasm 0 trials · 8 incl. sub-types
12 sub-types
- Malignant cranial nerve neoplasm 0 trials · 4 incl. sub-types Sub-types →
- Olfactory nerve neoplasm 0 trials · 4 incl. sub-types Sub-types →
- Optic nerve neoplasm 1 trial · 4 incl. sub-types Sub-types →
- Abducens nerve neoplasm 0 trials
- Facial nerve neoplasm 0 trials
- Glossopharyngeal nerve neoplasm 0 trials Sub-types →
- Hypoglossal nerve neoplasm 0 trials Sub-types →
- Oculomotor nerve neoplasm 0 trials Sub-types →
- Spinal accessory nerve neoplasm 0 trials
- Trigeminal nerve neoplasm 0 trials Sub-types →
- Trochlear nerve neoplasm 0 trials
- Vestibulocochlear nerve neoplasm 0 trials Sub-types →
-
Tonsil neoplasm 0 trials · 8 incl. sub-types
2 sub-types
- Tonsil cancer 5 trials · 8 incl. sub-types Sub-types →
- Benign neoplasm of tonsil 0 trials Sub-types →
-
Odontogenic neoplasm 0 trials · 5 incl. sub-types
4 sub-types
- Keratocystic odontogenic tumor 3 trials
- Ameloblastoma 2 trials Sub-types →
- Ameloblastic carcinoma 0 trials
- Calcifying epithelial odontogenic tumor 0 trials
-
Ocular adnexal lymphoma 4 trials
-
Malignant epithelial tumor of salivary glands 0 trials · 4 incl. sub-types
1 sub-type
-
Ear neoplasm 0 trials · 3 incl. sub-types
5 sub-types
- Malignant ear neoplasm 0 trials · 2 incl. sub-types Sub-types →
- External ear neoplasm 0 trials · 1 incl. sub-types Sub-types →
- Inner ear neoplasm 0 trials · 1 incl. sub-types Sub-types →
- Neoplasm of middle ear 0 trials · 1 incl. sub-types Sub-types →
- Benign neoplasm of ear 0 trials Sub-types →
-
Familial thyroglossal duct cyst 2 trials
-
Buccal mucosa neoplasm 0 trials · 2 incl. sub-types
2 sub-types
- Cheek mucosa cancer 1 trial · 2 incl. sub-types Sub-types →
- Benign neoplasm of buccal mucosa 0 trials Sub-types →
-
Gingival neoplasm 0 trials · 2 incl. sub-types
3 sub-types
- Gingival cancer 1 trial · 2 incl. sub-types Sub-types →
- Benign neoplasm of gum 0 trials Sub-types →
- Congenital epulis 0 trials
-
Neoplasm of floor of mouth 0 trials · 2 incl. sub-types
2 sub-types
- Malignant tumor of floor of mouth 0 trials · 2 incl. sub-types Sub-types →
- Benign neoplasm of floor of mouth 0 trials
-
Palatal neoplasm 0 trials · 2 incl. sub-types
4 sub-types
- Hard palate cancer 0 trials · 1 incl. sub-types Sub-types →
- Soft palate cancer 0 trials · 1 incl. sub-types Sub-types →
- Benign neoplasm of hard palate 0 trials
- Benign neoplasm of soft palate 0 trials
-
Head and neck paraganglioma 1 trial
4 sub-types
- Carotid body paraganglioma 0 trials Sub-types →
- Jugulotympanic paraganglioma 0 trials Sub-types →
- Tympanic paraganglioma 0 trials
- Vagus nerve paraganglioma 0 trials
-
Cavernous hemangioma of face 0 trials
1 sub-type
- Cavernous hemangioma of retina 0 trials
-
Epignathus 0 trials
-
Facial dermoid cyst 0 trials
2 sub-types
- Nasal dermoid cyst 0 trials
- Orbital dermoid cyst 0 trials
-
Gasserian ganglion meningioma 0 trials
-
Laryngeal neuroendocrine neoplasm 0 trials
1 sub-type
- Laryngeal small cell carcinoma 0 trials
-
Laryngotracheal angioma 0 trials
-
Lipoma of face 0 trials
1 sub-type
- Lipoma of the conjunctiva 0 trials
-
Nasal ganglioglioma 0 trials
-
Nasal glial heterotopia 0 trials
Most studied deeper sub-types
-
Vaccine trains immune system to target HPV-Linked cancers
Cure CompletedResearchers are testing a vaccine called BNT113 in people whose cancers are driven by HPV16, a common virus linked to head and neck, cervical, and anogenital tumors. The trial enrolls two groups: one with head and neck cancer that has been treated and shows no signs of disease, a…
Phase 1/2 • Sponsor: University of Southampton • Aim: Cure
Last updated Sep 18, 2026 00:00 UTC
-
Drug combo shows promise for tough head and neck cancers
Disease control CompletedThis phase 2 study tested two drugs—durvalumab and cetuximab—together in 35 people with head and neck cancer that had come back or spread and was no longer responding to standard treatments. The goal was to see if the combination could shrink tumors. The study is complete, and re…
Phase 2 • Sponsor: University of Cincinnati • Aim: Disease control
Last updated Sep 04, 2026 00:00 UTC
-
Can MRI-Guided radiation boost the power of immunotherapy in head and neck cancer?
Disease control CompletedThis early-phase trial is testing a new way to deliver radiation therapy for people with advanced head and neck cancer. Using MRI guidance, doctors can adjust the radiation dose in real time—giving higher doses to remaining tumor while reducing doses to areas that have shrunk. Th…
Phase 1 • Sponsor: Medical College of Wisconsin • Aim: Disease control
Last updated Aug 22, 2026 00:00 UTC
-
Immunotherapy combo shows promise in reducing head and neck cancer recurrence
Disease control CompletedThis phase 2 trial tested whether adding the immunotherapy drug pembrolizumab (Keytruda) to standard surgery, radiation, and chemotherapy could help prevent head and neck cancer from coming back. The study enrolled 67 adults with advanced, surgically removable head and neck squam…
Phase 2 • Sponsor: Washington University School of Medicine • Aim: Disease control
Last updated Aug 07, 2026 00:00 UTC
-
New drug cocktail shows promise for tough head and neck cancers
Disease control CompletedThis study tested a combination of two drugs, atezolizumab and bevacizumab, in 33 adults with advanced head and neck cancer that had worsened after chemotherapy. The goal was to see if the combo could shrink tumors or slow disease progression. Results may help guide future treatm…
Phase 2 • Sponsor: Centre Leon Berard • Aim: Disease control
Last updated Jun 27, 2026 12:23 UTC
-
Immunotherapy combo shows promise in head and neck cancer trial
Disease control CompletedThis large Phase 3 trial tested whether adding the immunotherapy drug pembrolizumab (Keytruda) to standard chemoradiation helps people with locally advanced head and neck cancer live longer without the disease getting worse. Over 800 participants received either pembrolizumab plu…
Phase 3 • Sponsor: Merck Sharp & Dohme LLC • Aim: Disease control
Last updated Jun 27, 2026 09:01 UTC
-
New drug combo shows promise for Tough-to-Treat head and neck cancer
Disease control CompletedThis study tested a combination of two drugs, pembrolizumab and cetuximab, in 78 people with advanced head and neck cancer that had returned or spread. The goal was to see if the combination could shrink tumors or slow the disease. Participants were grouped based on whether they …
Phase 2 • Sponsor: University of California, San Diego • Aim: Disease control
Last updated Jun 27, 2026 09:00 UTC
-
New oral drug takes on standard chemo for head and neck cancer
Disease control CompletedThis Phase 3 trial tested whether the oral drug afatinib works better than the standard injected drug methotrexate for people with advanced head and neck cancer that has worsened after platinum chemotherapy. The study enrolled 340 patients and measured how long they lived without…
Phase 3 • Sponsor: Boehringer Ingelheim • Aim: Disease control
Last updated Jun 27, 2026 08:10 UTC
-
Neck surgery before Chemo-Radiation may reduce side effects in head and neck cancer patients
Disease control CompletedThis study looked at 65 people with advanced head and neck cancer that had spread to lymph nodes. It compared two approaches: having surgery to remove affected lymph nodes before chemo-radiation, versus chemo-radiation alone. The goal was to see if upfront surgery could reduce tr…
Phase 3 • Sponsor: Insel Gruppe AG, University Hospital Bern • Aim: Disease control
Last updated Jun 27, 2026 07:59 UTC
-
Smarter radiation dosing aims to cut side effects for head and neck cancer patients
Disease control CompletedThis study tested a new way of giving radiation to people with head and neck cancer. The goal was to lower the radiation dose to healthy neck areas to reduce side effects like trouble eating, while still keeping the cancer from coming back. About 300 patients took part, and the r…
Phase 3 • Sponsor: Radboud University Medical Center • Aim: Disease control
Last updated Jun 27, 2026 07:57 UTC
-
Experimental combo targets HPV-Driven head and neck tumors
Disease control CompletedThis Phase 2 trial tested a combination of two immunotherapies—PDS0101 and pembrolizumab (Keytruda)—in 95 adults with HPV16-positive head and neck cancer that had returned or spread. The goal was to see if the combo could shrink tumors or slow the disease. Participants received b…
Phase 2 • Sponsor: PDS Biotechnology Corp. • Aim: Disease control
Last updated Jun 27, 2026 07:53 UTC
-
Heavy lifting may help cancer survivors rebuild strength
Symptom relief CompletedThis study tests whether a heavy lifting strength training program is safe and helpful for people who have finished treatment for head and neck cancer at least one year ago. Researchers want to see if it improves muscle strength, physical function, fatigue, and quality of life co…
Phase 2 • Sponsor: University of Alberta • Aim: Symptom relief
Last updated Aug 14, 2026 00:00 UTC
-
Pre-Treatment workouts may boost strength in head and neck cancer patients
Symptom relief CompletedThis study tested whether a short exercise program before chemoradiotherapy helps head and neck cancer patients maintain physical function. 47 adults with head and neck cancer were randomly assigned to either an exercise prehabilitation group or usual care. The exercise program l…
Sponsor: Associacao de Investigacao de Cuidados de Suporte em Oncologia • Aim: Symptom relief
Last updated Jun 27, 2026 12:00 UTC
-
Ozone treatment eases painful mouth sores in cancer patients
Symptom relief CompletedThis study tested whether ozone therapy can help treat oral mucositis—painful mouth sores—in 38 patients receiving radiation and chemotherapy for head and neck cancer. Patients received in-office ozone gas treatment plus at-home ozonated oil products. The researchers measured cha…
Sponsor: Andrea Scribante • Aim: Symptom relief
Last updated Jun 27, 2026 09:00 UTC
-
Acupuncture needles may boost blood counts and ease fatigue in cancer patients
Symptom relief CompletedThis study tested whether manual acupuncture, compared to a sham (fake) version, could improve white blood cell counts and reduce fatigue in 34 head and neck cancer patients undergoing chemoradiation. Participants received 21 sessions over seven weeks at specific body points. The…
Sponsor: Indonesia University • Aim: Symptom relief
Last updated Jun 27, 2026 08:07 UTC
-
Laser or ozone: which eases cancer mouth sores best?
Symptom relief CompletedThis study tested two treatments—laser therapy and ozone gas—to relieve painful mouth sores caused by cancer treatment. Forty adults with head and neck or blood cancers took part. Each received one treatment daily for five days. The goal was to see which therapy better reduced so…
Sponsor: University of Pavia • Aim: Symptom relief
Last updated Jun 27, 2026 07:58 UTC
-
Nutrition boost may ease radiation side effects in head and neck cancer
Symptom relief CompletedThis completed study tested whether active nutritional support with high-protein drinks can reduce the occurrence of painful mouth sores (mucositis) and improve quality of life in head and neck cancer patients undergoing radiotherapy. The study enrolled 47 newly diagnosed adults …
Sponsor: Assiut University • Aim: Symptom relief
Last updated Jun 26, 2026 15:27 UTC
-
X-Ray study tracks head movement during cancer radiation
Knowledge-focused CompletedThis study collected X-ray images from 32 head and neck cancer patients during their radiation therapy sessions. The goal was to measure how much the head moves or changes shape between treatments. Researchers also used the images to create realistic artificial X-rays for future …
Sponsor: University of Sydney • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:35 UTC
-
New imaging technique could help doctors predict cancer treatment response
Knowledge-focused CompletedThis study tested whether a PET scan using a tracer called FMISO can measure oxygen levels (hypoxia) in head and neck cancers. Sixteen patients received the scan before starting radiotherapy. The goal was to see if the amount of hypoxia seen on the scan could predict how well the…
Sponsor: University Hospital, Bordeaux • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:32 UTC
-
Which breathing tube method is safer for head and neck cancer patients?
Knowledge-focused CompletedThis study tested two devices that help doctors place a breathing tube before surgery in 143 head and neck cancer patients with difficult airways. One device is a flexible scope, and the other combines that scope with a video laryngoscope. The goal was to see which method reduces…
Sponsor: M.D. Anderson Cancer Center • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:06 UTC
-
3D nerve mapping could make Kids' head and neck surgery safer
Knowledge-focused CompletedThis completed study tested a new 3D MRI technique to map cranial nerves in 7 children aged 1 to 5 with head and neck tumors or birth defects. The goal was to create detailed models that help surgeons avoid damaging important nerves during operations. The research focused on deve…
Sponsor: Assistance Publique - Hôpitaux de Paris • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:00 UTC