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Ozone treatment eases painful mouth sores in cancer patients

NCT ID NCT07247799

Symptom relief Sponsor: Andrea Scribante Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This study tested whether ozone therapy can help treat oral mucositis—painful mouth sores—in 38 patients receiving radiation and chemotherapy for head and neck cancer. Patients received in-office ozone gas treatment plus at-home ozonated oil products. The researchers measured changes in sore severity, pain levels, and quality of life. The goal was to see if this approach could reduce discomfort and improve daily activities like eating.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
ozone therapy (medical ozone gas and ozonated oil products)
What this could lead to
If effective, ozone therapy could offer a simple, non-drug way to reduce painful mouth sores and improve eating and quality of life during cancer treatment.
What could go wrong
This is a small, retrospective study with only 38 participants and no comparison group. Results may not apply to all patients, and ozone therapy is not yet a standard treatment.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

38 people

The number who actually took part.

Started

Sep 2025

Finished

Jan 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Patients under orthodontic care at the Section of Dentistry

Ages

40 to 85 years

Sex

Anyone

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * patients undergoing radio and chemotherapy for head and neck cancer and cancers in other districts Exclusion Criteria: * syndromic patients * pregnant women * patients with cardiac pacemakers * epileptic patients * patients with high sensitivity to electric current

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Conditions

The condition(s) this trial relates to.

head and neck neoplasm Head and Neck Neoplasms stomatitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Head and neck neoplasms Oral mucositis

Contacts and locations

Locations

  • Unit of Dental Hygiene - Section of Dentistry - Department of Clinical, Surgical, Diagnostic and Paediatrics - University of Pavia

    Pavia, Lombardy, 27100, Italy

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